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Faculty Directory

Hye Jin YOU

Hye Jin YOU, Ph.D.(Adjunct Professor)
Faculty Appointment
(title, department)
Professor, Department of Cancer Biomedical Science, NCC-GCSP
Senior Scientist, National Cancer Center
Area of Expertise
Cancer Bology/Metastasis/TGFβ& IGF-1 signaling
Work Experience
2007- present: National Cancer Center as an Associate/Senior Scientist
2005-2007: Duke University Medical Center as a Research Associate
Educational Background
Ph.D. Cell Signaling, GIST, Korea (2005)
M.S. Molecular Physiology, GIST, Korea (2000)
B.S. Biochemistry, Yonsei University (1998)
Research Interests (Please place in paragraph form)
Dr. You’s scientific interest is to understand cellular mechanism how tumor cells survive and become malignant during tumor progression. To do this, Dr. You focuses on altered genes and their functional relationship in response to IGF-1 or TGFβ signaling in tumor cells.
International Collaboration
2022 SCI-E Molecular Mechanisms and Current Treatment Options for Cancer CachexiA: CANCERS. 14(9):2107~ (6.575)

2022 SCI-E USP15 and USP4 facilitate lung cancer cell proliferation by regulating the alternative splicing of SRSF1: CELL DEATH DISCOVERY. 8(1):24~ (7.109)

2021 SCI-E Rapid androgen-responsive proteome is involved in prostate cancer progression: BIOMEDICINES. 9(12):1877~ (6.081)

2021 SCI-E O-GlcNAcylation of Sox2 at threonine 258 regulates the self-renewal and early cell fate of embryonic stem cells.: EXPERIMENTAL AND MOLECULAR MEDICINE. 53(11):1759~1768 (8.718)

2021 SCI-E TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma: MOLECULES AND CELLS. 44(11):784~794 (5.034)

2021 SCI-E Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation: EXPERIMENTAL AND MOLECULAR MEDICINE. 53(10):1559~1568 (8.718)

2021 SCI-E Characterization of proteins regulated by androgen and protein kinase A signaling in VCaP prostate Cancer Cells: BIOMEDICINES. 9(10):1404~ (6.081)

2021 SCI-E Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8+ T cell responses: CELLULAR & MOLECULAR IMMUNOLOGY. Online:Published (8.484)

2020 SCI-E The Role of Nuclear Receptor Subfamily 1 Group H Member 4 (NR1H4) in Colon Cancer Cell Survival through the Regulation of c-Myc Stability: MOLECULES AND CELLS. 43(5):459~468 (4.081)

2020 SCI-E Targeting TJP1 attenuates cell-cell aggregation and modulates chemosensitivity against doxorubicin in leiomyosarcoma: JOURNAL OF MOLECULAR MEDICINE-JMM. 98(5):761~773 (4.427)

2019 SCI-E A Mutation in ZNF143 as a Novel Candidate Gene for Endothelial Corneal Dysplasia: journal of clinical medicine. 8(8):1174~1174 (5.688)

2019 SCI-E Loss of zinc-finger protein 143 contributes to tumour progression by interleukin-8-CXCR axis in colon cancer: Journal of Cellular and Molecular Medicine. 23(6):4043~4053 (4.658)

2019 SCI-E The Role of ZNF143 in Breast Cancer Cell Survival Through the NAD(P)H Quinone Dehydrogenase 1-p53-Beclin1 Axis Under Metabolic Stress: CELLS. 8(4):E296~E296 (5.656)

2018 SCI-E Integrated molecularcharacterization of adult soft tissue sarcoma fortherapeutic targets: BMC medical genetics. 19(supple1):216~216 (1.913)

2018 SCI Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness: Experimental & molecular medicine. 50(1):137~137 (5.584)

2018 SCI-E BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer: BMB Reports. 51(8):373~377 (3.085)

2017 SCI-E Zinc finger Protein 143 expression is closely related to tumor malignancy via regulating cell motility in breast cancer.: BMB reports. 50(12):621~627 (3.089)

2016 SCI Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity.: Experimental and Molecular Medicine. 48(12):e277~e277 (5.164)

2016 SCI-E Oncogenic function and clinical implications of SLC3A2-NRG1 fusion in invasive mucinous adenocarcinoma of the lung: Oncotarget. 7(43):69450~69465 (5.008)

2015 SCI Regulationofcancercelldeathbyanovelcompound,C604,in a c-Myc-overexpressingcellularenvironment: European Journal of Pharmacology. 769:257~265 (2.532)

2015 SCI-E Tight junction protein 1 is regulated by transforming growth factor-β and contributes to cell motility in NSCLC cells: BMB reports. 48(2):115~120 (2.595)

2014 SCI A role of zinc-finger protein 143 for cancer cell migration and invasion through ZEB1 and E-cadherin in colon cancer cells.: Molecular Carcinogenesis. 53(s1):e161~e168 (4.77)

2013 SCI Transglutaminase-2 induces N-cadherin expression in TGF-beta1-induced epithelial mesenchymal transition via c-Jun-N-terminal kinase activation by Protein Phosphatase 2A down-regulation: European Journal of Cancer. 49(7):1692~1705 (5.061)

2011 SCI GAIP-interacting protein, C-terminus is involved in the induction of zinc-finger protein 143 in response to insulin-like growth factor-1 in colon cancer cells: Molecules and Cells. 32:415~419 (2.046)

2010 SCI IGF-1 induces expression of zinc-finger protein 143 in colon cancer cells through phosphatidylinositide-3-kinase and reactive oxygen species: Experimental and Molecular Medicine. 42(10):696~702 (2.304)

2010 SCI Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice: Atherosclerosis. 212:146~152 (4.522)

2010 SCI GIPC mediates the generation of reactive oxygen species and the regulation of cancer cell proliferation by insulin-like growth factor-1/IGF-1R signaling.: Cancer Letters. 294(2):254~263 (3.741)

2010 SCI-E Glucosylsphingosine Induces Itch-Scratch Responses in Mice: Biomolecules & Theprapeutics. 18:316~320 (0.292)

2009 SCI The type III transforming growth factor-{beta} receptor negatively regulates nuclear factor-{kappa}B signaling through its interaction with {beta}-arrestin2.: Carcinogenesis. 30:1281~1287 (4.93)

2008 SCI Endocytosis of the Type III TGF-β receptor through the clathrin-independent/lipid raft pathway regulates TGF-β signaling and receptor downregulation.: Journal of Biological Chemistry. 283:34808~34818 (5.581)

2008 SCI Tumor Necrosis Factor-alpha Develops Late Anaphylactic Reaction through Cytosolic Phospholipase A2 Activation: international archives of allergy and immunology. 147:315~322 (2.16)

2007 SCI The type III TGF-{beta} Receptor Signals through both Smad3 and the p38 MAP Kinase Pathways to Contribute to Inhibition of Cell Proliferation.: Carcinogenesis. 28:2491~2500 (5.366)

2007 SCI Leukotriene synthesis in response to A23187 is inhibited by methyl- beta-cyclodextrin in RBL-2H3 cells: Molecules and Cells. 23:57~63 (1.872)

2006 SCI Inhibition of receptor internalization attenuates the TNFalpha-induced ROS generation in non-phagocytic cells: Biochem Biophys Res Commun. 351:972~978 (2.855)

2006 SCI Glutamine inhibits lipopolysaccharide-induced cytoplasmic phospholipase A2 activation and protects against endotoxin shock in mouse: Shock. 25:290~294 (3.318)

2005 SCI TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation: Journal of Allergy Clinical Immunology. 116:537~543 (8.829)

2005 SCI Molecular properties of excitation-contraction coupling proteins in infant and adult human heart tissues: Molecules and Cells. 20:51~56 (1.872)

2005 SCI Roles of Rac and p38 kinase in the activation of cytosolic phospholipase A2 in response to PMA: Biochemical Journal. 388:527~535 (4.1)

2005 SCI Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes: Biochem Biophys Res Commun. 328:595~600 (2.855)

2004 SCI Rac1 contributes to maximal activation of STAT1 and STAT3 in IFN-gamma-stimulated rat astrocytes: Journal of Immunology. 173:5697~5703 (6.293)

2004 SCI A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium: Biochem Biophys Res Commun. 321:657~664 (2.855)

2004 SCI Rac and protein kinase C-delta regulate ERKs and cytosolic phospholipase A2 in FcepsilonRI signaling to cysteinyl leukotriene synthesis in mast cells: Journal of Immunology. 173:624~631 (6.293)

2003 SCI Transepithelial migration of neutrophils in response to leukotriene B4 is mediated by a reactive oxygen species-extracellular signal-regulated kinase-linked cascade: Journal of Immunology. 170:6273~6279 (6.293)

2002 SCI Implication of the small GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6 astroglioma cells: Biochemical Journal. 366:937~943 (4.1)

2002 SCI Leukotriene B(4) stimulates Rac-ERK cascade to generate reactive oxygen species that mediates chemotaxis: Journal of Biological Chemistry. 277:8572~8578 (5.808)

2001 SCI Role of the cytosolic phospholipase A2-linked cascade in signaling by an oncogenic, constitutively active Ha-Ras isoform: Journal of Biological Chemistry. 276:24645~24653 (5.808)

2000 SCI Tumor necrosis factor-alpha generates reactive oxygen species via a cytosolic phospholipase A2-linked cascade: Journal of Biological Chemistry. 275:32357~32362 (5.808)

2000 SCI Annexin-I inhibits PMA-induced c-fos SRE activation by suppressing cytosolic phospholipase A2 signal: FEBS letters. 477:244~248 (3.372)