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Faculty Directory

Byong Chul YOO

Byong Chul YOO, Ph.D.(adjunct professor)
Faculty Appointment
(title, department)
Professor, Department of Cancer Biomedical Science, NCC-GCSP

Area of Expertise
Biochemistry / Proteomics
Work Experience
Chief, Biomarker Branch, Research Institute, National Cancer Center (2017-Present)
Chief, Colorectal Cancer Branch, National Cancer Center (2013-2017)
Senior Scientist , Colorectal Cancer Branch, Division of Translational & Clinical Research I, National Cancer Center (2006-2013)
Chief, Colorectal Cancer Branch, Division of Common Cancers, National Cancer Center Research Institute (2004-2005)
Educational Background
B.S, Sung Kyun Kwan University (1991-1996)
M.S, Sung Kyun Kwan University, Graduate School, Korea (1996-1998)
Ph.D., University of Vienna, Vienna, Austria
Research Interests
International Collaboration
2018 SCI Deleted in malignant brain tumor 1 is a novel prognostic marker in colorectal cancer: Oncology reports. Online:Published (2.662)

2018 SCI-E Momordica charantia Inhibits Inflammatory Responses in Murine Macrophages via Suppression of TAK1: The American Journal of Chinese Medicine. 46:1~18 (3.222)

2018 SCI Inhibition of VEGF-dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a: Molecular Oncology. Online:Published (5.314)

2017 SCI-E Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action: Oncotarget. 9(5):5979~5992 (5.168)

2017 SCI-E Cerebrospinal fluid metabolomic profiles can discriminate patients with leptomeningeal carcinomatosis from patients at high risk for leptomeningeal metastasis: Oncotarget. 8(60):101203~101214 (5.168)

2017 SCI-E Reduced levels of N’-methyl-2-pyridone-5-carboxamide and lysophosphatidylcholine 16:0 in the serum of patients with intrahepatic cholangiocarcinoma, and the correlation with recurrence-free survival: Oncotarget. 8(68):112598~112609 (5.168)

2017 SCI-E Profiling of Serum Metabolites Using MALDI-TOF and Triple-TOF Mass Spectrometry to Develop a Screen for Ovarian Cancer.: Cancer Research and Treatment. Online:Published (3.772)

2017 SCI Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents: Amino Acids. 49(9):1469~1485 (3.173)

2017 SCI Clinical multi-omics strategies for the effective cancer management: Journal of Proteomics. Online:Published (3.914)

2017 SCI SET domain-containing protein 5 is required for expression of primordial germ cell specification-associated genes in murine embryonic stem cells: Cell Biochemistry and Function. 35(5):247~253 (2.186)

2017 SCI Syk Plays a Critical Role in the Expression and Activation of IRAK1 in LPS-Treated Macrophages: Mediators of Inflammation. 2017:1506248~1506249 (3.232)

2017 SCI Therapeutic effects of hyaluronidase on acquired lymphedema using a newly developed mouse limb model: Experimental Biology and Medicine. 242(6):584~592 (2.688)

2017 SCI-E Identification of calgranulin B interacting proteins and network analysis in gastrointestinal cancer cells: PLoS One. 12(2):e0171232~e0171232 (2.806)

2017 SCI-E Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116: Oncotarget. 8(4):6819~6823 (5.008)

2016 SCI-E Pyrrole-Derivative of Chalcone, (E)-3-Phenyl-1-(2-Pyrrolyl)-2-Propenone, Inhibits Inflammatory Responses via Inhibition of Src, Syk, and TAK1 Kinase Activities: Biomolecules & Therapeutics. 24(6):595~603 (2.127)

2016 SCI-E Low-mass-ion discriminant equation (LOME) for ovarian cancer screening: BioData Mining. 9:32~32 (1.64)

2016 SCI Seven low-mass ions in pretreatment serum as potential predictive markers of the chemoradiotherapy response of rectal cancer: Anti cancer Drugs. 27:787~793 (2.268)

2016 SCI-E Critical role of protein L-isoaspartyl methyltransferase in basic fibroblast growth factor-mediated neuronal cell differentiation.: BMB Reports. 49(8):437~442 (2.782)

2016 SCI-E Antitumor effects of calgranulin B internalized in human colon cancer cells: Oncotarget. 7(15):20368~20380 (5.008)

2016 SCI The Role of Protein Arginine Methyltransferases in Inflammatory Responses: Mediators of Inflammation. 2016:4028353~4028353 (3.418)

2016 SCI Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid: Mediators of Inflammation. 2016:1903849~1903849 (3.418)

2015 SCI-E Reduced expression of HSP27 following HAD-B treatment is associated with Her2 downregulation in NIH:OVCAR-3 human ovarian cancer cells.: Molecular medicine reports. 12(3):3787~3794 (1.554)

2015 SCI Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells: PLoS biology. 13(5):1002152~1002152 (9.343)

2015 SCI Anti-inflammatory Activities of Gouania leptostachya Methanol Extract and its Constituent Resveratrol: Phytotherapy research. 29(3):381~392 (2.66)

2015 SCI-E Identification of Hypoxanthine and Phosphoenolpyruvic Acid as Serum Markers of Chemoradiotherapy Response in Locally Advanced Rectal Cancer: Cancer research and treatment. 47(1):78~89 (3.318)

2015 SCI The Role of Fibrinogen as a Predictor in Preoperative Chemoradiation for Rectal Cancer: Annals of surgical oncology. 22(1):209~215 (3.93)

2015 SCI Ga-68-labeled neolactosylated human serum albumin (LSA) for PET imaging of hepatic asialoglycoprotein receptor: Nuclear medicine and biology. 42(1):53~58 (2.412)

2014 SCI-E Ginsenoside-Rp1-induced apolipoprotein A-1 expression in the LoVo human colon cancer cell line: Journal of ginseng research. 38(4):251~255 (2.295)

2014 SCI-E A predictive model combining fecal calgranulin B and fecal occult blood tests can improve the diagnosis of colorectal cancer: PloS one. 9(9):e106182~e106182 (3.534)

2014 SCI-E Differential levels of L-homocysteic acid and lysophosphatidylcholine (16:0) in sera of patients with ovarian cancer: Oncology letters. 8(2):566~574 (0.987)

2014 SCI The Regulatory Role of Activating Transcription Factor 2 in Inflammation: Mediators of Inflammation. 2014:950472~950472 (2.417)

2014 SCI (5-Hydroxy-4-oxo-4H-pyran-2-yl)methyl 6-hydroxynaphthalene-2-carboxylate, a kojic acid derivative, inhibits inflammatory mediator production via the suppression of Syk/Src and NF-κB activation: International Immunopharmacology. 20(1):37~45 (2.711)

2014 SCI Low-mass-ion discriminant equation: A new concept for colorectal cancer screening.: International Journal of Cancer. 134(8):1844~1853 (5.007)

2014 SCI-E Regulatory B Subunits of Protein Phosphatase 2A Are Involved in Site-specific Regulation of Tau Protein Phosphorylation.: Korean Journal of Physiology and Pharmacology (대한생리학회). 18(2):155~161 (1.262)

2014 SCI Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses: Mediators of Inflammation. 2014:352371~352383 (2.417)

2014 SCI-E Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells: BMC Cancer. 14:160~160 (3.319)

2014 SCI Decreased Cellular Levels of Palmitic Amide are Linked to 5-fluorouracil Resistance in Human Colon Cancer Cells: Hepato-gastroenterology. 61(130):343~348 (0.907)

2014 SCI CD133 and CD133-regulated nucleophosmin linked to 5-fluorouracil susceptibility in human colon cancer cell line SW620: Electrophoresis. 35(4):522~532 (3.161)

2013 SCI Adenosine dialdehyde suppresses MMP-9-mediated invasion of cancer cells by blocking the Ras/Raf-1/ERK/AP-1 signaling pathway: Biochemical Pharmacology. 86(9):1285~1300 (4.576)

2013 SCI Transglutaminase2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma: The FASEB Journal. 27(9):3487~3495 (5.704)

2013 SCI Involvement of Src and the actin cytoskeleton in the antitumorigenic action of adenosine dialdehyde.: Biochemical Pharmacology. 85(8):1042~1056 (4.576)

2013 SCI Hydroquinone regulates hemeoxygenase-1 expression via modulation of Src kinase activity through thiolation of cysteine residues.: Free Radical Biology and Medicine. 57:105~118 (5.271)

2013 SCI HangAmDan-B, an Ethnomedicinal Herbal Mixture, Suppresses Inflammatory Responses by Inhibiting Syk/NF-κB and JNK/ATF-2 Pathways: Journal of Medicinal Food. 16(1):56~65 (1.642)

2013 SCI PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.: Cellular Signalling. 25(1):74~84 (4.304)

2013 SCI Depletion of cathepsin D by transglutaminase2 through protein cross-linking promotes cell survival: Amino Acids. 44(1):73~80 (3.914)

2012 SCI-E Up-regulated expression of l-caldesmon associated with malignancy of colorectal cancer: BMC Cancer. 12(1):601~601 (3.011)

2012 SCI The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses: Mediators of Inflammation. 2012:512926~512926 (3.263)

2012 SCI Induction of LGR5 by H2O2 treatment is associated with cell proliferation via the JNK signaling pathway in colon cancer cells.: International Journal of Oncology. 41(5):1744~1750 (2.399)

2012 SCI Hydroxymethylglutaryl-Coenzyme A Synthase 2 Expression Is Associated With Chemoradiotherapy Responses in Colorectal Cancer: Diseases of the Colon & Rectum. 55(6):686~694 (3.132)

2011 SCI-E PTEN Modulates miR-21 Processing via RNA-Regulatory Protein RNH1: PLoS ONE. 6(12):e28308~e28308 (4.411)

2011 SCI Lipid profiles for intrahepatic cholangiocarcinoma identified using matrix-assisted laser desorption/ionization mass spectrometry.: Clinica chimica acta. 412(21-22):1978~1982 (2.389)

2011 SCI-E Proteome alteration in human colon cancer cells by the treatment of HangAmDan-B: Biochip Journal. 5:114~122 (0.868)

2011 SCI Development of (68)Ga-labeled mannosylated human serum albumin (MSA) as a lymph node imaging agent for positron emission tomography.: Nuclear Medicine and Biology. 38:371~379 (2.62)

2011 SCI p38-Targeted inhibition of interleukin-12 expression by ethanol extract from Cordyceps bassiana in lipopolysaccharide-activated macrophages.: Immunopharmacol Immunotoxicol.. 33:90~96 (1.209)

2011 SCI Posttranslational arginine methylation of lamin A/C during myoblast fusion.: Biochimca et Biophysica Acta. 1814(2):308~317 (2.773)

2010 SCI Regulation of post-translational protein arginine methylation during HeLa cell cycle: Biochim Biophys Acta. 1800(9):977~985 (2.958)

2010 SCI-E Promoter hypermethylation and loss of CD133 gene expression in colorectal cancers.: World Journal of Gastroenterology. 16:3153~3160 (2.092)

2010 SCI Akt Cys-310-targeted Inhibition by Hydroxylated Benzene Derivatives Is Tightly Linked to Their Immunosuppressive Effects: Journal of Biological Chemistry. 285(13):9932~9948 (5.328)

2010 SCI Identification of hypoxanthine as a urine marker for non-Hodgkin lymphoma by low-mass-ion profiling: BMC Cancer. 10:55~55 (2.736)

2009 SCI Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B: Biochim Biophys Acta - Molecular Cell Research. 1793:1656~1668 (4.893)

2009 SCI Upregulation of glycolytic enzymes in proteins secreted from human colon cancer cells with 5-fluorouracil resistance: Electrophoresis. 30(12):2182~2192 (3.509)

2009 SCI Galectin-3 stabilizes heterogeneous nuclear ribonucleoprotein Q to maintain proliferation of human colon cancer cells: Cellular and Molecular Life Sciences. 66:350~364 (5.511)

2009 SCI Identification of genes with differential expression in chemoresistant epithelial ovarian cancer using high-density oligonucleotide microarrays.: Oncology Research. 18:47~56 (1.209)

2008 SCI Differentiation between human normal colon mucosa and colon cancer tissue using ToF-SIMS imaging technique and principal component analysis: Applied Surface Science. 255:1119~1122 (1.406)

2008 SCI Evaluation of calgranulin B in stools from the patients with colorectal cancer: Diseases of the Colon & Rectum. 51(11):1703~1709 (2.621)

2008 SCI Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells: Cancer Science. 99(10):1884~1891 (3.165)

2008 SCI-E Upregulated HSP27 in human breast cancer cells reduces Herceptin susceptibility by increasing Her2 protein stability: BMC Cancer. 8:286~295 (2.709)

2008 SCI Increased cytoplasmic levels of CIS, SOCS1, SOCS2, or SOCS3 are required for nuclear translocation: FEBS Letters. 582:2319~2324 (3.263)

2007 SCI-E Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas: Pathology & Oncology Research. 13:326~335 (1.241)

2007 SCI Identification of mitochondrial F(o)F(1)-ATP synthase involved in liver metastasis of colorectal cancer: Cancer Science. 98:1184~1191 (3.869)

2007 SCI Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma: Oncology reports. 17:81~87 (1.567)

2006 SCI Regulation of MDF expression in human cancer cells modulates sensitivities to various anticancer drugs: MDK overexpression confers to a multi-drug resistance: Cancer Letters. Online:Published (3.277)

2005 SCI 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole acts in a reactive oxygen species-dependent manner to suppress human lung cancer growth: J Cancer Res Clin Oncol.. :1~11 (2.409)

2005 SCI Mutation spectrum of the APC gene in 83 Korean FAP families: HUMAN MUTATION. 26:281~292 (6.845)

2005 SCI Familial gastric cancers with Li-Fraumeni syndrome: WORLD JOURNAL OF GASTROENTEROLOGY. 11:4124~4126 (3.318)

2005 SCI Metabotropic Glutamate Receptor 4 Expression in Colorectal carcinoma and Its prognostic Significance: Clinical Cancer Research. 11:3288~3295 (6.511)

2005 SCI Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma: Human Patholgy. 36:364~371 (3.685)

2005 SCI Down-regulation of Mitochondria F1F0-ATP Synthase in Human Colon Cancer Cells with Induced 5-Fluorouracil Resistance: CANCER RESEARCH. 68:3162~3170 (8.649)

2004 SCI Germline Mutations in MLH1, MSH2 and MSH6 in Korean Hereditary Non-Polyposis Colorectal Cancer Families: HUM MUTAT. 24(4):895~899 (6.328)

2004 SCI Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line: CLINICAL CANCER RESEARCH. 10:4176~4184 (6.511)

2004 SCI Decreased pyruvate kinase M2 activity linked to cisplatin resistance in human gastric carcinoma cell lines: INTERNATIONAL JOURNAL OF CANCER. 108:532~539 (4.056)

2004 SCI Identification of genes with differential expression in acquired drug-resistant gastric cancer cells using high-density oligonucleotide microarrays: CLIN CANCER RES. 10:272~284 (5.991)

2002 SCI Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob disease: NEUROSCIENCE LETTERS. 334:196~200 (2.019)

2002 SCI Expression patterns of antioxidant proteins in brains of patients with sporadic Creutzfeldt-Jacob disease: ELECTROPHORESIS. 23:2541~2547 (3.743)

2001 SCI p25 protein in neurodegeneration: NATURE. 411:763~764 (32.182)

2001 SCI Evidence for apoptosis in the fetal Down syndrome brain: JOURNAL OF CHILD NEUROLOGY. 16:438~442 (1.333)

2001 SCI Synaptosomal proteins, beta-soluble N-ethylmaleimide-sensitive factor attachment protein (beta-SNAP), gamma-SNAP and synaptotagmin I in brain of patients with Down syndrome and Alzheimer's disease: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 12:219~225 (2.493)

2001 SCI Differential expression of molecular chaperones in brain of patients with Down syndrome: ELECTROPHORESIS. 22:1233~1241 (3.743)

2001 SCI Differential display reveals downregulation of the phospholipid transfer protein (PLTP) at the mRNA level in brains of patients with Down syndrome: LIFE SCIENCES. 68:2169~2179 (2.158)

2001 SCI Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 281:84~93 (2.904)

2001 SCI Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 280:249~258 (2.904)

2001 SCI Changes of voltage-dependent anion-selective channel proteins VDAC1 and VDAC2 brain levels in patients with Alzheimer's disease and Down syndrome: ELECTROPHORESIS. 22:172~179 ()

2001 SCI Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down syndrome: dysregulation of T-complex protein 1: JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT. 61:321~334 (1.449)

2001 SCI Neurofilament proteins NF-L, NF-M and NF-H in brain of patients with Down syndrome and Alzheimer's disease: AMINO ACIDS. 21:293~301 (2)

2001 SCI Alteration of caspases and other apoptosis regulatory proteins in Down syndrome: JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT. 61:163~179 (1.449)

2001 SCI Down syndrome patients start early prenatal life with normal cholinergic, monoaminergic and serotoninergic innervation: JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT. 61:303~310 (1.449)

2000 SCI Neuroendocrine-specific protein C, a marker of neuronal differentiation, is reduced in brain of patients with Down syndrome and Alzheimer's disease: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 276:329~334 (2.904)

1999 SCI Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease: JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT. 57:315~322 (1.449)

1999 SCI Differential display reveals deteriorated mRNA levels of NADH3 (complex I) in cerebellum of patients with Down syndrome: JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT. 57:211~220 (1.449)

1999 SCI Inhibitory effect of arginine-derivatives from ginseng extract and basic amino acids on protein-arginine N-methyltransferase: AMINO ACIDS. 17:391~400 (2)

1998 SCI Partial purification of protein farnesyl cysteine carboxyl methyltransferase from bovine brain: EXPERIMENTAL AND MOLECULAR MEDICINE. 30:227~234 (1.712)