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Park, Eun-Jung

Eun Jung PARK, Ph.D.(full-time professor)
Faculty Appointment
Professor, Department of Cancer Biomedical Science, NCC-GCSP
Area of Expertise
Inflammation, Tumor Immunology, Cancer Immunology
Work Experience
Chief, Cancer Immunology Branch (Immune and Cell Therapy Branch), National Cancer Center, Korea (2007-Present)
Chief, Immune and Cell Therapy Branch, National Cancer Center, Korea (2007-2012)
Visiting Scholar, Dept. of Biological Science, UCSD, USA (Sep. 2009 – Aug. 2010)
Director, GMP System Construction TF, National Cancer Center, Korea (Nov. 2007 – Aug. 2009)
Full-time Instructor, Ajou University School of Medicine, Korea(Sep. 2004 – Aug. 2006)
Educational Background
Ph. D. Molecular Biology, Seoul National University (1999)
MS Molecular Biology, Seoul National University (1993)
B.A. Biology, Ewha Womans University (1990)
Research Interests
Dr. Park’s primary research interests are in immune and inflammatory responses, especially pathological inflammatory responses and sterile inflammation. Her current research activities are mainly focused on the understanding of how inflammatory responses is set in motion and controlled, how we control the abnormal inflammation associated with diseases including cancer. Some latest research topics are tumor immunomicroenvironment and immunotherapy, TLRs in brain inflammation, oxidative stress and HIFs, and damage-associated endogenous molecules. She is now putting great emphasis on the crosstalk between cancer and immune cells and the interdependence of hypoxic stress and immune responses
International Collaboration
2022 SCI-E Adipocyte HIF2a functions as a thermostat via PKACa regulation in beige adipocytes: NATURE COMMUNICATIONS. 13(1):3268~ (17.694)

2022 SCI-E A host non-coding RNA, nc886, plays a pro-viral role by promoting virus trafficking to the nucleus: MOLECULAR THERAPY-ONCOLYTICS. 24:683~694 (6.311)

2021 SCI-E Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-b-catenin-driven M2 macrophage: MOLECULAR THERAPY-ONCOLYTICS. 23:138~150 (7.2)

2021 SCI-E Nc886, a Novel Suppressor of the Type I Interferon Response Upon Pathogen Intrusion: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22(4):2003~ (5.924)

2021 SCI-E Preclinical evaluation of radiation therapy of BRCA1-associated mammary tumors using a mouse model: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES. 17(3):689~701 (6.582)

2021 SCI-E Anticancer nanocage platforms for combined immunotherapy designed to harness immune checkpoints and deliver anticancer drugs: BIOMATERIALS. 270:120685~ (12.479)

2021 SCI-E Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma: BRAIN. 144(2):636~654 (13.501)

2020 SCI-E Glial TIM-3 Modulates Immune Responses in the Brain Tumor Microenvironment: CANCER RESEARCH. 80(9):1833~1845 (9.727)

2019 SCI Glial TLR2-driven innate immune responses and CD8+ T cell activation against brain tumor: Glia. 67(6):1179~1195 (5.829)

2018 SCI Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland: Analytical Cellular Pathology. 2018:8~8 (1.574)

2018 SCI Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors: EXPERIMENTAL & MOLECULAR MEDICINE. 50(10):136~136 (5.584)

2018 SCI Inhibition of Estrogen signaling reduces the incidence of BRCA1-associated mammary tumor formation: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES. 14(12):1755~1768 (4.057)

2018 SCI JIB-04, A small molecule histone demethylase inhibitor, selectively targets colorectal cancer stem cells by inhibiting the Wnt/B-catenine signaling pathway: SCIENTIFIC REPORTS. 2018(8):66111~66111 (4.122)

2017 SCI-E CHK2 is involved in the p53-independent radiosensitizing effects of valproic acid: Oncology Letters. 13(4):2591~2598 (1.39)

2017 SCI Glatiramer acetate attenuates the activation of CD4+ T cells by modulating STAT1 and -3 signaling in glia: Scientific Reports. 7:40484~40484 (4.259)

2016 SCI-E nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer: Oncotarget. 7(46):75000~75012 (5.008)

2015 SCI Distinctive responses of brain tumor cells to TLR2 ligands:: Glia. 63(5):894~905 (6.031)

2015 SCI The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.: Nature communications [electronic resource]. 6:6340~6340 (11.47)

2015 SCI Anti-neuroinflammatory effects of DPTP, a novel synthetic clovamide derivative in in vitro and in vivo model of neuroinflammation.: Brain research bulletin. 112:25~34 (2.718)

2014 SCI-E EOP, a Newly Synthesized Ethyl Pyruvate Derivative, Attenuates the Production of Inflammatory Mediators via p38, ERK and NF-κB Pathways in Lipopolysaccharide-Activated BV-2 Microglial Cells.: Molecules. 19(12):19361~19375 (2.095)

2013 SCI-E Resveratrol Confers Protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells: PLos One. 8(4):e60654~60654 (3.73)

2013 SCI-E Regulation of microglia activity by glaucocalyxin-a: attenuation of lipopolysaccharide-stimulated neuroinflammation through NF-kB and p38 MAPK signaling pathways: PLos One. 8(2):e55792~e55792 (3.73)

2012 SCI Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necrotopsis: nature communications. 3:978~982 (7.396)

2011 SCI Dual Functionality of Myeloperoxidase in rotenone-exposed brain-resident immune cells: American Journal of Pathology. 179(2):964~979 (5.224)

2010 SCI Galectin-3 exerts cytokine-like regulatory actions through the JAK-STAT pathway: Journal of Immunology. 185(11):7037~7046 (5.646)

2010 SCI Inflexin attenuates proinflammatory responses and nuclear factor kappa B activation in LPS-treated microglia: European Journal of Pharmacology. 633(1-3):98~106 (2.585)

2009 SCI Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T cells: Molecules and Cells. 28:533~558 (2.023)

2009 SCI-E Expression Profiling of Neuroinflammatory Genes in LPS and LPS/IFNgamma-stimulated BV2 microglia cells: Biochip Journal. 3:299~305 (0.65)

2009 SCI-E Genome-wide Inspection of Chromosomal Aberrations in Microglia BV-2 Cells by Array-based Comparative Genomic Hybridization: Biochip Journal. 3:28~36 (0.65)

2008 SCI Sulfatide, a major lipid component of myelin sheath, activates inflammatory responses as an endogenous stimulator in brain-resident immune cells: Journal of Immunology. 181:8077~8087 (6.068)

2008 SCI Regulation of TLR2 expression by prostaglandins in brain glia.: Journal of Immunology. 180(12):8400~8409 (6.068)

2008 SCI Contribution of TLR2 to the initiation of ganglioside-triggered inflammatory signaling: Molecules and Cells. 25:99~104 (1.916)

2006 SCI Induction of microglial apoptosis by corticotropin-releasing hormone.: Journal of Neurochemistry. 98:962~972 (4.604)

2006 SCI Gangliosides trigger inflammatory responses via TLR4 in brain glia.: American Journal of Pathology. 168:1619~1630 (6.946)

2005 SCI Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells: Glia. 50:66~79 (4.781)

2004 SCI Rac1 Contributes to Maximal Activation of STAT1 and STAT3 in IFN--Stimulated Rat Astrocytes: Journal of Immunology. 2004:5697~5703 (6.702)

2003 SCI Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia: Journal of Immunology. 171:6072~6079 (6.702)

2003 SCI 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia: Journal of biological Chemistry. 278:14747~14752 (7.68)

2002 SCI A glucose-inducible gene in Schizosaccharomyces pombe, rrg1+, is involved in negative regulation of G2/M progression: Mol Cells. 14:312~317 (1.872)

2002 SCI JAK-STAT Signaling Mediates Gangliosides-induced Inflammatory Responses in Brain Microglial Cells: Journal of Biological Chemistry. 277:40594~40601 (7.68)

2002 SCI Interleukin-13 and -4 induce death of activated microglia: Glia. 38:273~280 (4.78)

2001 SCI Reactive oxygen species mediate A[beta](25-35)-induced activation of BV-2 microglia. Reactive oxygen species mediate A[beta](25-35)-induced activation of BV-2 microglia.: NeuroReport. 12:1449~1452 (2.7)

1999 SCI Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells.: Nucleic Acid Research. 27:1524~1530 ()