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Sang Jin LEE

Sang Jin LEE, Ph.D.(adjunct professor)
Faculty Appointment
Professor, Department of Cancer Biomedical Science, NCC-GCSP
Area of Expertise
Molecular Oncology/Anti-Cancer Gene&Cell Therapy
Work Experience
Head of Animal Experimental Facility, Research Institute, National Cancer Center, Korea (-at present)
Chief of Genitourinary Cancer Branch, Research Institute, National Cancer Center, Korea (-2017.02)
Research Associate Professor in Indiana Medical School (-2005.10)
Visiting Scholar in Kobe University (-2005.05)
Research Associate Professor in Indiana Medical School (-2005.10)
Educational Background
PhD, University of Virginia
MS, University of Wisconsin-Madison
BS, Seoul National University
Research Interests
Researches in my laboratory are focused on developing new cancer therapeutic modalities. Targeting indications are on genitourinary and liver cancers. Especially, my laboratory is interested in gene and cell therapies or the combination of both of them. Recently, we make big efforts to translate what we already developed.
International Collaboration
Chinghai Kao, Indiana Medical School, USA
Toshiro Shirakawa, Kobe Medical School, Japan
2022 SCI-E Targeted Inhibition of O-Linked β-N-Acetylglucosamine Transferase as a Promising Therapeutic Strategy to Restore Chemosensitivity and Attenuate Aggressive Tumor Traits in Chemoresistant Urothelial Carcinoma of the Bladder: BIOMEDICINES. 10(5):1162~ (4.757)

2022 SCI-E A host non-coding RNA, nc886, plays a pro-viral role by promoting virus trafficking to the nucleus: MOLECULAR THERAPY-ONCOLYTICS. 24:683~694 (6.311)

2021 SCI-E Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-b-catenin-driven M2 macrophage: MOLECULAR THERAPY-ONCOLYTICS. 23:138~150 (7.2)

2020 SCI-E Prognostic Implication of SOX2 Expression Associated with p16 in Oropharyngeal Cancer: A Study of Consecutive Tissue Microarrays and TCGA: BIOLOGY-BASEL. 9(11):387~ (3.796)

2020 SCI-E Glial TIM-3 Modulates Immune Responses in the Brain Tumor Microenvironment: CANCER RESEARCH. 80(9):1833~1845 (9.727)

2020 SCI-E Docetaxel-resistant prostate cancer cells become sensitive to gemcitabine due to the upregulation of ABCB1: PROSTATE. 80(6):453~462 (3.279)

2020 SCI-E Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging: PLOS ONE. 15(1):e0223814~e0223814 (2.74)

2019 SCI Association Between Postoperative Detection of Circulating Tumor Cells and Recurrence in Patients with Prostate Cancer: THE JOURNAL OF UROLOGY. Online:Published (5.647)

2019 SCI-E CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation: cancers. 11(10):1583~1583 (6.162)

2019 SCI Intravesical delivery of rapamycin via folate-modified liposome dispersed in thermo-reversible hydrogel: International Journal of Nanomedicine. 14:6249~6268 (4.471)

2018 SCI Phase I trial of intravenous Ad5CRT in patients with liver metastasis of gastrointestinal cancers: Cancer gene therapy. 26(5-6):174~175 (4.044)

2018 SCI The immunotherapeutic effects of recombinant Bacillus Calmette-Gurerin resistant to antimicrobial peptides on bladder cancer cells: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 509(1):167~174 (2.559)

2018 SCI-E Targeting CD46 Enhances Anti-Tumoral Activity of Adenovirus Type 5 for Bladder Cancer: International Journal of Molecular Sciences. 19(9):2694~2694 (3.687)

2018 기타 Prostate stem cell antigen mRNA in blood is a predictor of survival after radical prostatectomy in patients with high-risk prostate cancer.: Oncotarget. 9(41):26291~26298 (0)

2017 SCI Electrostatic interaction of tumor-targeting adenoviruses with aminoclay acquires enhanced infectivity to tumor cells inside the bladder and has better cytotoxic activity: Drug Delivery. 25(1):49~58 (6.402)

2017 SCI Epigenetic regulation of RNA polymerase III transcription in early breast tumorigenesis: Oncogene. 36(49):6793~6804 (7.519)

2017 SCI-E Recommended oral sodium bicarbonate administration for urine alkalinization did not affect the concentration of mitomycin-C in non-muscle invasive bladder cancer patients: oncotarget. Online:Published (5.168)

2017 SCI 2-Hydroxyoleic acid-inserted liposomes as a multifunctional carrier of anticancer drugs: Drug Delivery. 24:1587~1597 (6.402)

2017 SCI Optimization and physicochemical characterization of a cationic lipid-phosphatidylcholine mixed emulsion formulated as a highly efficient vehicle that facilitates adenoviral gene transfer: International Journal of Nanomedicine. 12:7323~7335 (4.3)

2017 SCI CTLA4-CD28 chimera gene modification of T cells enhances the therapeutic efficacy of donor lymphocyte infusion for hematological malignancy: Experimental and Molecular Medicine. 49(7):e360~e360 (5.063)

2017 SCI-E Lectin, galactoside-binding soluble 3 binding protein promotes 17-N-Allylamino-17-demethoxygeldanamycin resistance through PI3K/Akt pathway in lung cancer cell line: Molecular Cancer Therapeutics. 16(7):1355~1365 (5.764)

2017 SCI-E Establishment and application of bladder cancer patient-derived xenografts as a novel preclinical platform: Translational Cancer Research. 6(S4):s733~s743 (1.167)

2017 SCI Ninjurin1 Is Up-regulated in Circulating Prostate Tumor Cells and Plays a Critical Role in Prostate Cancer Cell Motility: anticancer research. 34(4):1687~1696 (1.937)

2017 SCI The Effectiveness of Ferritin as a Contrast Agent for Cell Tracking MRI in Mouse Cancer Models: Yonsei Medical Journal. 58(1):51~58 (1.537)

2016 SCI Aminoclay as a highly effective cationic vehicle for enhancing adenovirus-mediated gene transfer through nanobiohybrid complex formation: Acta Biomaterialia. 49:521~530 (6.008)

2016 SCI-E The establishment of a growth-controllable orthotopic bladder cancer model through the down-regulation of c-myc expression: Oncotarget. Online:Published (5.008)

2016 SCI Ninjurin1 suppresses metastatic property of lung cancer cells through inhibition of Interleukin-6 signaling pathway: International journal of cancer. 139(2):383~395 (5.531)

2016 SCI-E Efficacy of CD46-targeting chimeric Ad5/35 adenoviral gene therapy for colorectal cancers: Oncotarget. 7(25):38210~38223 (5.008)

2016 SCI-E Ninjurin1 inhibits colitis-mediated colon cancer development and growth by suppression of macrophage infiltration through repression of FAK signaling: Oncotarget. 7(20):29592~29604 (5.008)

2016 SCI-E Improving gastric cancer preclinical studies using diverse in vitro and in vivo model systems: BMC Cancer. 16(1):200~200 (3.265)

2016 SCI-E Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma: Theranostics. 6:357~368 (8.854)

2015 SCI Ad5/35E1aPSESE4: a Novel Approach to Marking Circulating Prostate Tumor Cells with a Replication Competent Adenovirus Controlled by PSA/PSMA Transcription Regulatory Elements: Cancer Letters. 382(1):57~64 (5.621)

2015 SCI-E The quantified level of circulating prostate stem cell antigen mRNA relative to GAPDH level is a clinically significant indictor for predicting biochemical recurrence in prostate cancer patients after radical prostatectomy: BioMed Research International. 2015:292454~292454 (1.579)

2015 SCI-E Daurinol enhances the efficacy of radiation therapy in lung cancer via suppression of aurora kinase A/B expression: Molecular cancer therapeutics. 14(7):1693~1704 (5.683)

2015 SCI-E Humanized anti-hepatocyte growth factor (HGF) antibody suppresses innate irinotecan (CPT-11) resistance induced by fibroblast-derived HGF: Oncotarget [electronic resource]. 2015:1~1 (6.359)

2015 SCI-E Changes in urination according to the sound of running water using a mobile phone application: PloS one [electronic resource]. 10(5):0126798~0126798 (3.234)

2015 SCI Evaluation of preventive and therapeutic activity of novel non-steroidal anti-inflammatory drug, CG100649, in colon cancer: Increased expression of TNF-related apoptosis-inducing ligand receptors enhance the apoptotic response to combination treatment with TRAIL: Oncology reports. 33(4):1947~1955 (2.301)

2015 SCI CD200: Association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma.: Head & neck. 37(3):327~335 (2.641)

2015 SCI P70S6K and Elf4E Dual Inhibition Is Essential to Control Bladder Tumor Growth and Progression in Orthotopic Mouse Non-muscle Invasive Bladder Tumor Model: Journal of Korean medical science. 30(3):308~316 (1.266)

2015 SCI Low-dose cisplatin converts the tumor microenvironment into a permissive state for HSVtk-induced antitumor immunity in HPV16-related tonsillar carcinoma: Cancer letters. 356(2PtB):743~750 (5.621)

2014 SCI Formulation and in vitro and in vivo evaluation of a cationic emulsion as a vehicle for improving adenoviral gene transfer: International Journal of Pharmaceutics. 475(1-2):49~59 (3.785)

2014 기타 A milk protein, casein, as a proliferation promoting factor in prostate cancer cells: The world journal of men's health. 32(2):76~82 (0)

2014 SCI The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores.: Nature Communications. 5:4588~4588 (10.742)

2014 SCI-E Development of Replication-competent Adenovirus for Bladder Cancer by Controlling Adenovirus E1a and E4 Gene Expression with the Survivin Promoter: Oncotarget [electronic resource]. 5(14):5615~5623 (6.627)

2014 SCI Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model: Cancer Letters. 344(2):223~231 (5.016)

2014 SCI Establishment of an Orthotopic Mouse Non-Muscle Invasive Bladder Cancer Model Expressing the Mammalian Target of Rapamycin Signaling Pathway: J of Korean Med Sci. 29(3):343~350 (1.253)

2014 SCI Intravesical instillation of c-MYC inhibitor KSI-3716 suppresses orthotopic bladder tumor growth: The Journal of Urology. 191(2):510~518 (3.753)

2014 SCI-E Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer: Oncotarget. 5(2):326~337 (6.627)

2014 SCI Loss of β2-spectrin prevents cardiomyocyte differentiation and heart development: Cardiovascular Research. 101(1):39~47 (5.808)

2014 SCI-E Effectiveness of intracavernous delivery of adenovirus encoding Smad7 gene on erectile function in a mouse model of cavernous nerve injury: The journal of sexual medicine(J Sex Med). 11(1):51~63 (3.15)

2013 SCI-E Genetic variations of α -methylacyl-CoA racemase are associated with sporadic prostate cancer risk in ethnically homogenous Koreans: Biomed Research International. 2013:1~11 (0)

2013 SCI-E Development of an immunotherapeutic adenovirus targeting hormone-independent prostate cancer: Onco Targets and Therapy. 6:1635~1642 (2.073)

2013 SCI-E Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway: Oncotarget. 4(10):1791~1803 (6.636)

2013 SCI Adenovirus expressing both thymidine kinase and soluble PD1 enhances anti-tumor immunity by strengthening CD8 T cell response: Molecular Therapy. 21(3):688~695 (7.041)

2012 SCI Effects of Prolyl 4-Hydroxylase Inhibitor on Bladder Function, Bladder Hypertrophy and Collagen Subtypes in a Rat Model With Partial Bladder Outlet Obstruction.: Urology. 80(6):e7~e12 (2.428)

2012 SCI Association of common variations of 8q24 with the risk of prostate cancer in Koreans and a review of the Asian population: British Journal of Urology International. 110(6ptB):E318~E325 (2.844)

2012 SCI Over-expression of miR-145 Enhances the Effectiveness of HSVtk gene Therapy for Malignant Glioma: Cancer Letters. 320(1):72~80 (4.238)

2012 SCI Positive conversion of negative signaling of CTLA4 potentiates antitumor efficacy of adoptive T-cell therapy in murine tumor models: Blood. 119(24):5678~5687 (9.898)

2012 SCI STAT3 silencing enhances the efficacy of the suicide gene in gastrointestinal cancer therapy: Clinical & Experimental Metastasis. 29(4):359~369 (3.524)

2011 SCI A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy: nature nanotechnology. 6(10):675~682 (30.324)

2011 SCI Blocking the immunosuppressive axis with small interfering RNA targeting interleukin (IL)-10 receptor enhances dendritic cell-based vaccine potency.: Clinical and experimental immunology. 165(2):180~189 (3.134)

2011 SCI Haplotype Analysis of Prostate Stem Cell Antigen and Association With Prostate Cancer Risk.: The Journal of Urology. 185(6):2112~2118 (3.862)

2011 기타 TNF-a mediated NF-kB activation is constantly extended by transglutaminase: Frontiers in Bioscience(Elite Ed). 3(1):341~354 (0)

2010 SCI-E Transforming growth factor (TGF)-β type I receptor kinase (ALK5) inhibitor alleviates profibrotic TGF-β1 responses in fibroblasts derived from Peyronie's plaque.: Journal of Sexual Medicine. 7(10):3385~3395 (4.884)

2010 SCI The development of the conditionally replication-competent adenovirus: replacement of E4 orf1-4 region by exogenous gene.: Journal of Gene Medicine. 12(5):453~462 (2.968)

2010 SCI Does skin temperature difference as measured by infrared thermography within 6 months of acute herpes zoster infection correlate with pain level?: Skin Research and Technology. 16(2):198~201 (1.307)

2010 SCI Galectin-3 Increases Gastric Cancer Cell Motility by Up-regulating Fascin-1 Expression: Gastroenterology. 138:1035~1045 (12.899)

2009 SCI Comparison of two full automatic synthesis methods of 9- (4-[18F]Fluoro-3-hydroxymethylbutyl)guanine using different chemistry modules: Applied Radiation & Isotopes. 67:1758~1763 (1.114)

2009 SCI-E IN-1130, a Novel Transforming Growth Factor-beta Type I Receptor Kinase (Activin Receptor-like Kinase 5) Inhibitor, Promotes Regression of Fibrotic Plaque and Corrects Penile Curvature in a Rat Model of Peyronie's Disease: Journal of Sexual Medicine. 6(5):1284~1296 (5.393)

2009 SCI-E IN-1130, a Novel Transforming Growth Factor-beta Type I Receptor Kinase (Activin Receptor-like Kinase 5) Inhibitor, Promotes Regression of Fibrotic Plaque and Corrects Penile Curvature in a Rat Model of Peyronie's Disease: Journal of Sexual Medicine. 6(5):1284~1296 (5.393)

2008 SCI Expression of Bmi-1 protein in tumor tissues is associated with favorable prognosis in breast cancer patients: Breast Cancer Research and Treatment. 113:83~93 (4.453)

2008 SCI Antitumor effects of systemically delivered adenovirus harboring trans-splicing ribozyme in intrahepatic colon cancer mouse model: Clinical Cancer Research. 14:281~290 (6.25)

2007 SCI Overexpression of Apollon, an antiapoptotic protein, is associated with poor prognosis in childhood de novo acute myeloid leukemia.: Clinical Cancer Research. 13(17):51109~51114 (6.177)