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Ho LEE, Ph.D.(full-time professor)
Faculty Appointment
(title, department)
Professor and Department Chair, Department of Cancer Biomedical Science, NCC-GCSP
Senior Scientist, Research Institute, National Cancer Center
Area of Expertise
Mouse Genetics of Cancer Models
Work Experience
Researcher, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Korea
Visiting Scientist, Department of Pediatric and Adolescent Medicine, Mayo Clinic, USA
Educational Background
1994 Seoul National University, Seoul, Korea; Bachelor’s Degree
1996 Seoul National University, Department of Microbiology, Seoul, Korea; Master’s Degree
2001 Seoul National University, School of Biological Sciences, Seoul, Korea; Ph.D.
Research Interests (Please place in paragraph form)
Dr. Ho LEE, earned his PhD from Seoul National University, Korea, and has performed a three-year postdoctoral research in the field of cell cycle regulation and mouse genetics in the Department of Biological Sciences at Korea Advanced
Institute of Science and Technology, Korea. Following that, Dr Lee joined the Research Institute of National Cancer Center as a junior faculty member staff.
His current research interests include mouse genetics of cancer models and pluripotency and differentiation in embryonic/adult stem cell.
International Collaboration
2022 SCI-E PRR16/Largen induces epithelial-mesenchymal transition through the interaction with ABI2 leading to the activation of ABL1 kinase: BIOMOLECULES & THERAPEUTICS. 30(4):340~347 (4.231)

2022 SCI-E Unique characteristics of lung resident neutrophils are maintained by PGE2/PKA/Tgm2-mediated signaling: BLOOD. Online:Published (25.476)

2022 SCI-E Obesity-Associated Cancers: Evidence from Studies in Mouse Models: CELLS. 11(9):1472~ (7.666)

2022 SCI-E Loss of EMP2 inhibits melanogenesis of MNT1 melanoma cells via regulation of TRP-2: BIOMOLECULES & THERAPEUTICS. 30(2):203~211 (4.231)

2022 SCI-E PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23(4):2391~ (6.208)

2022 SCI-E Promotion of the infammatory response in mid colon of complement component 3 knockout mice: SCIENTIFIC REPORTS. 12(1):1700~ (4.996)

2022 SCI-E The Pellino1?PKCu Signaling Axis Is an Essential Target for Improving Antitumor CD8þ T Lymphocyte Function: CANCER IMMUNOLOGY RESEARCH. 10(3):327~342 (12.02)

2022 SCI-E Mammalian Ssu72 phosphatase preferentially considers tissue-specific actively transcribed gene expression by regulating RNA Pol II transcription: THERANOSTICS. 12(1):186~206 (11.6)

2022 SCI-E A serum marker for early pancreatic cancer with a possible link to diabetes: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 114(2):228~234 (13.506)

2021 SCI-E Resolvin D1 Suppresses H2O2-Induced Senescence in Fibroblasts by Inducing Autophagy through the miR-1299/ARG2/ARL1 Axis: ANTIOXIDANTS. 10(12):1924~ (6.313)

2021 SCI-E LW1497, an Inhibitor of Malate Dehydrogenase, Suppresses TGF- b1-Induced Epithelial-Mesenchymal Transition in Lung Cancer Cells by Downregulating Slug: ANTIOXIDANTS. 10(11):1674~ (6.313)

2021 SCI-E Ssu72-HNF4α Signaling Axis Classify the Transition From Steatohepatitis To Hepatocellular Carcinoma: CELL DEATH AND DIFFERENTIATION. Online:Published (15.828)

2021 SCI-E Ssu72 phosphatase directly binds to ZAP-70, thereby providing fine-tuning of TCR signaling and preventing spontaneous inflammation: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 118(35):e210237411~ (11.205)

2021 SCI-E Metformin and niclosamide synergistically suppress Wnt and YAP in APC-mutated colorectal cancer: CANCERS. 13(14):3437~ (6.639)

2021 SCI-E Reply to Krupenko et al., Comment on “Lee et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer Cancers 2020, 12, 1382”: CANCERS. 13(9):2238~ (6.639)

2021 SCI-E Ssu72 is a T-cell receptor-responsive modifier that is indispendable for regulatory T cell: CELLULAR & MOLECULAR IMMUNOLOGY. 18(6):1395~1411 (11.53)

2021 SCI-E A resource of targeted mutant mouse lines for 5061 genes: NATURE GENETICS. 53(4):416~419 (38.33)

2021 SCI-E Altered distributions in circulating follicular helper and follicular regulatory T cells accountable for imbalanced cytokine production in multiple sclerosis: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. Online:Published (4.33)

2021 SCI-E Overall survival of pancreatic ductal adenocarcinoma is doubled by Aldh7a1 deletion in the KPC mouse: THERANOSTICS. 11(7):3472~3488 (11.556)

2021 SCI-E Ethacrynic acid, a loop diuretic, suppresses epithelial-mesenchymal transition of A549 lung cancer cells via blocking of NDP-induced WNT signaling,: BIOCHEMICAL PHARMACOLOGY. 183:114339~ (5.858)

2021 SCI-E Deficiency of complement component 3 may be linked to the developemtn of constipation in FVB/N-C3 mice: FASEB JOURNAL. 35(1):e21221~ (4.966)

2021 기타 Rapid way to generate mouse models for in vivo studies of the endothelium: Journal of Lipid and Atherosclerosis. 10(1):24~41 (0)

2020 SCI-E Deletion of NKX3.1 via CRIPSR/Cas9 induces prostatic intraepithelial neoplasia in C57BL/8 mice: TECHNOLOGY IN CANCER RESEARCH & TREATMENT. 19:1533033820964425~ (2.074)

2020 SCI-E NSD3-induced methylation of H3K36 activates NOTCH signaling to drive breast tumor initiation and metastatic progression: CANCER RESEARCH. Online:Published (9.727)

2020 SCI-E Ssu72 regulates alveolar macrophage development and allergic airway inflammation by fine tuning of GM-CSF receptor signaling: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. S0091-6749(20):31235-5~ (10.228)

2020 SCI-E ATP Production Relies on Fatty Acid Oxidation Rather than Glycolysis in Pancreatic Ductal Adenocarcinoma: CANCERS. 12(9):2477~ (6.126)

2020 SCI-E Targeting Oxidative Phosphorylation Reverses Drug Resistance in Cancer Cells by Blocking Autophagy Recycling: CELLS. 9(9):2013~ (4.366)

2020 SCI-E The chromatin-binding protein PHF6 functions as an E3 ubiquitin ligase of H2BK120 via H2BK12Ac recognition for activation of trophectodermal genes: NUCLEIC ACIDS RESEARCH. 48(16):9037~9052 (11.501)

2020 SCI-E PHF7 modulates BRDT stability and histone-to-protamine exchange during spermiogenesis: CELL REPORTS. 32(4):107950~ (8.109)

2020 SCI-E The catalytically defective receptor protein tyrosine kinase EphA10 promotes tumorigenesis in pancreatic cancer cells: CANCER SCIENCE. 111(9):3292~3302 (4.966)

2020 SCI-E The Combination Loss of ALDH1L1 function and phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer: CANCERS. 12(6):E1382~ (6.126)

2020 SCI-E Twist2 promotes CD8+ T-cell differentiation by repressing ThPOK expression: CELL DEATH AND DIFFERENTIATION. Online:Published (10.717)

2020 SCI-E NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter: CELL DEATH & DISEASE. 11(1):38~ (6.304)

2019 SCI-E Ascorbic acid 2-glucoside stably promotes the primitiveness of embryonic and mesenchymal stem cells through TET- and CREB1- dependent mechanisms.: Antioxidants & redox signaling. 32(1):35~59 (5.828)

2019 SCI Loss of Mob1a/b impairs the differentiation of mouse embryonic stem cells into the three germ layer lineages: EXPERIMENTAL & MOLECULAR MEDICINE. 11:135~135 (4.743)

2019 SCI-E Ubiquitin E3 ligase Pellino-1 inhibits IL-10-mediated M2c polarization of macrophages, thereby suppressing tumor growth: IMMUNE NETWORK. 19(5):e32~ (3.637)

2019 SCI RORa is crucial for attenuated inflammatory response to maintain intestinal homeostasis: PNAS. 42:21140~21149 (9.58)

2019 SCI-E YDJC induces epithelial-mesenchymal transition via escaping from interaction with CDC16 through ubiquitination of PP2A.: JOURNAL OF ONCOLOGY. Online:Published (2.6)

2019 SCI-E Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 144(5):1425~1428 (14.11)

2019 SCI SARNP, a participant inmRNAsplicing and export, negatively regulates E?cadherin expression via interaction with pinin: Journal of Cellular Physiology. Online:Published (4.522)

2019 SCI Phospholipase C-β1 potentiates glucose-stimulated insulin secretion: FASEB JOURNAL. 33(10):10668~10679 (5.391)

2019 SCI Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks: NATURE COMMUNICATIONS. 10(1):1577~1577 (11.878)

2019 SCI-E Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation: EBIOMEDICINE. 40:184~197 (6.68)

2019 SCI TopBP1 deficiency impairs the localization of proteins involved in early recombination and results in meiotic chromosome defects during spermatogenesis: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 508(3):722~728 (2.559)

2018 기타 Mouse models of breast cancer in preclinical research: Laboratory Animal Research. 34(4):1~6 (0)

2018 SCI-E Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling: CELL DEATH AND DISEASE. 9(11):1083~1083 (5.638)

2018 SCI AIMP3 deletion induces acute radiation syndrome-like phenotype in mice: Scientific reports. 8(1):15025~15025 (4.122)

2018 SCI RELT negatively regulates the early phase of the T-cell response in mice: European journal of immunology. 48(1):1739~1749 (4.248)

2018 SCI-E AIMP3 depletion causes genome instability and loss of stemness in mouse embryonic stem cells: CELL DEATH AND DISEASE. 9(10):972~972 (5.638)

2018 기타 YdjC chitooligosaccharide deacetylase homolog induces keratin reorganization in lung cancer cells: involvement of interaction between YDJC and CDC16: Oncotarget. 9(33):22915~22928 (0)

2018 SCI Identification of genetic elements in metabolism by high-throughput mouse phenotyping: Nature communications. 9(1):288~288 (12.353)

2017 SCI RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network: nature communications. 8(1):162~162 (12.124)

2017 SCI Cytosolic Pellino-1-Mediated K63-Linked Ubiquitination of IRF5 in M1 Macrophages Regulates Glucose Intolerance in Obesity: Cell Reports. 20:832~845 (8.282)

2017 SCI-E Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction: Oncotarget. 8(19):31842~31855 (5.168)

2017 SCI-E The Hippo signaling pathway provides novel anti-cancer drug targets: Oncotarget. 8(9):16084~16098 (5.008)

2017 SCI Skin-Specific Deletion of Mis18α Impedes Proliferation and Stratification of Epidermal Keratinocytes.: Journal of Investigative Dermatology. 137(2):414~421 (6.915)

2016 SCI Deletion of exons 3 and 4 in the mouse Nr1d1 gene worsens high-fat diet-induced hepatic steatosis: Life Science. 166:13~19 (2.685)

2016 SCI Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes: Cell Death Differentiation. 23(11):1804~1814 (8.218)

2016 SCI Novel effects of sphingosylphosphorylcholine on invasion of breast cancer: Involvement of matrix metalloproteinase-3 secretion leading to WNT activation.: Biochimica et biophysica acta - Molecular Basis of Disease. 1862(9):1533~1543 (5.158)

2016 SCI Lats-Yap/Taz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development: Nature Communications. 7:11961~11961 (11.329)

2016 SCI CD81/Kai1 maintains the dormancy of long-term hematopoietic stem cells through interaction with DARC-expressing macrophages: Cell Stem Cell. 18(4):508 ~521 (22.387)

2016 SCI Novel effects of FTY720 on perinuclear reorganization of keratin network induced by sphingosylphosphorylcholine: Involvement of protein phhosphatase 2A and G-protein-coupled receptor-12: European journal of pharmacology. 775:86~95 (2.73)

2016 SCI Methylation-dependent Regulation of HIF-1α Stability Restricts Retinal and Tumour Angiogenesis: Nature Communications. 7:10347~10347 (11.329)

2016 SCI Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase.: Hepatology. 63(1):247~259 (11.055)

2015 SCI-E Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB singaling: Oncotarget [electronic resource]. 6(14):12529~12542 (6.359)

2015 SCI Pontin Functions as an Essential Coactivator for Oct4-Dependent LincRNA expression in Mouse Embryonic Stem Cells: Nature communications [electronic resource]. 6:6810~6810 (11.47)

2015 SCI-E Cardamonin Suppresses TGF-β1-Induced Epithelial Mesenchymal Transition via Restoring Protein Phosphatase 2A Expression.: Biomolecules & therapeutics. 23(2):141~148 (1.727)

2014 SCI Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination: The Journal of clinical investigation. 124(11):4976~4988 (13.765)

2014 SCI-E Genetically Engineered Mouse Models for Drug Development and Preclinical Trials: Biomolecules & therapeutics. 22(4):267~274 (0.841)

2014 기타 OGA heterozygosity suppresses intestinal tumorigenesis in Apc(min/+) mice: Oncogenesis. 3:e109~e109 (0)

2014 SCI Pontin is required for pre-TCR signaling at the β-selection checkpoint in T cell development: Biochemical and Biophysical Research Communications. 447(1):44~50 (2.281)

2014 SCI Phosphorylation of LSD1 by PKCα Is Crucial for Circadian Rhythmicity and Phase Resetting: Molecular Cell. 53(5):791~805 (14.464)

2014 SCI TopBP1 deficiency impairs V(D)J recombination during lymphocyte development: The EMBO journal. 33(3):217~228 (10.748)

2013 SCI Functional interplay between Aurora B kinase and Ssu72 phosphatase regulates sister chromatid cohesion: Nature communications. 302(4):2631~2631 (10.015)

2013 SCI cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.: EMBO journal. 32(11):1543~1555 (9.822)

2013 SCI CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner: European Journal of Immunology. 43(3):667~678 (4.97)

2012 SCI Suppression of Transglutaminase-2 is Involved in Anti-Inflammatory Actions of Glucosamine in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation.: Biomolecules & Therapeutics. 20:380~385 (0.694)

2012 SCI-E O-GlcNAcase is essential for embryonic development and maintenance of genomic stability: Aging Cell. 11(3):439~448 (6.265)

2012 SCI Roles of Mis18α in Epigenetic Regulation of Centromeric Chromatin and CENP-A Loading: Molecular Cell. 46(3):260~273 (14.178)

2012 SCI The SWI/SNF-like BAF Complex Is Essential for Early B Cell Development: The Journal of Immunology. 188(8):3791~3803 (5.788)

2012 SCI Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation: Cell Death and Diffrentiation. 19(2):321~332 (8.849)

2012 SCI TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/sepinB2 and transglutaminase 2: Proc. Natl. Acad. Sci. USA. 109(4):e177~e186 (9.681)

2011 SCI Cancer cells promote survival through depletion of the von Hippel Lindau tumor suppressor by protein crosslinking: Oncogene. 30(48):4780~4790 (7.414)

2011 SCI Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1813(10):1777~1783 (4.733)

2011 SCI TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells: The Journal of biological chemistry. 286(7):5414~5422 (5.328)

2010 SCI Transglutaminase 2 gene ablation protects against renal ischemic injury by blocking constant NF-κB activation.: Biochemical and biophysical research coommunications. 403:479~484 (2.548)

2010 SCI The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion: EMBO Journal. 29:3544~3557 (8.993)

2010 SCI Negative Regulation of Hypoxic Responses via Induced Reptin Methylation: Molecular Cell. 39:71~85 (14.608)

2008 SCI Increased cytoplasmic levels of CIS, SOCS1, SOCS2, or SOCS3 are required for nuclear translocation: FEBS Letters. 582:2319~2324 (3.263)

2008 SCI ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification: Cell Stem Cell. 2:497~507 (16.826)

2007 SCI The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels: Biochemical and Biophysical Research Communications. 360:333~338 (2.855)

2007 SCI Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkc activation: Biochemical and Biophysical Research Communications. 354:184~189 (2.855)

2006 SCI Mouse emi1 has an essential function in mitotic progression during early embryogenesis: Molecular and Cellular Biology. 26:5373~5381 (7.093)

2005 SCI The Centrosomal protein RAS association domain family protein 1A (RASSF1A)-binding protein 1 regulates mitotic progression by recruiting RASSF1A to spindle poles: Journal of biological chemistry. 280:3920~3927 (5.854)

2004 SCI The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex: Nature Cell Biology. 6:129~137 (19.717)

2003 SCI Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage: Molecular Cancer Research. 1:674~681 (4.317)

2003 SCI Sequential binding of SeqA to paired hemi-methylated GATC sequences mediates formation of higher order complexes.: Journal of Biological Chemistry. 278:34983~34989 (5.854)

2001 SCI SeqA protein aggregation is necessary for SeqA function.: Journal of Biological Chemistry. 276:34600~34606 (5.854)

2001 SCI Expression of the seqA gene is negatively modulated by the HU protein in Escherichia coli: Mol Gen Genet. 264:931~935 ()

1999 SCI Interaction of SeqA and Dam methylase on the hemimethylated origin of Escherichia coli chromosomal DNA replication.: Journal of Biological Chemistry. 274:11463~11468 ()

1997 SCI The binding of two dimers of IciA protein to the dnaA promoter 1P element enhances the binding of RNA polymerase to the dnaA promoter 1P.: Nucleic Acid Research. 25:3486~3489 ()