Faculty Directory
- Name
- Jong Heon KIM, Ph.D.(adjunct professor)
- Faculty Appointment
(title, department)
- Professor, Department of Cancer Biomedical Science, NCC-GCSP/National Cancer Center Senior Investigator, Cancer Cell & Molecular Biology Branch, Research Institute, National Cancer Center
- Area of Expertise
- RNA Molecular Biology/Post-transcriptional Regulation of Gene Expression
- E-mail
- jhkim@ncc.re.kr
- Work Experience
- Senior Investigator, Cancer Cell & Molecular Biology Branch, Research Institute, National Cancer Center (2012~present)
Senior Investigator, Carcinogenesis Branch, Research Institute, National Cancer Center (2007~2012)
Post-doctoral Fellow, Program in Molecular Medicine, University of Massachusetts Medical School, USA (2004~2007)
Post-doctoral Fellow, Pohang University of Science and Technology, Korea (2003~2004)
- Educational Background
- Ph.D. (2003) Pohang University of Science and Technology, Korea
M.S. (1999) Pohang University of Science and Technology, Korea
B.S. (1997) Sung Kyun Kwan University, Korea
- Research Interests (Please place in paragraph form)
- Dr. Jong Heon KIM is senior investigator in Cancer Cell & Molecular Biology Branch, Research Institute and he is also associate professor of System Cancer Science department at NCC-GCSP. His current researches are focused on molecular turnover mechanism of oncogenic non-coding RNAs (e.g. microRNAs and IncRNAs) and interplay between non-coding RNAs and RNA-binding proteins/RNA modifiers during tumor genesis.
- International Collaboration
- Joel D. Richter, University of Massachusetts Medical School, USA
- Achievements
-
2022 SCI-E From Molecular Mechanisms to Therapeutics: Understanding MicroRNA-21 in Cancer: CELLS. :~ (7.666)
2022 SCI-E Different Metabolomic and Proteomic Profiles of Cerebrospinal Fluid in Ventricular and Lumbar Compartments in Relation to Leptomeningeal Metastases: METABOLITES. 12(1):80~ (5.581)
2021 SCI-E Experimental Assessment of Leptomeningeal Metastasis Diagnosis in Medulloblastoma Using Cerebrospinal Fluid Metabolomic Profiles: METABOLITES. 11(12):851~ (4.932)
2021 SCI-E Exploratory Profiling of Extracellular microRNAs in Cerebrospinal Fluid Comparing Leptomeningeal Metastasis with Other Central Nervous System Tumor Statuses: JOURNAL OF CLINICAL MEDICINE. 10(21):4860~ (4.242)
2021 SCI-E Regulation of Survival Motor Neuron Gene Expression by Calcium Signaling: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22(19):10234~ (5.924)
2021 SCI-E Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma: BRAIN. 144(2):636~654 (13.501)
2021 SCI-E Molecular Signature of Extracellular Vesicular Small Non-Coding RNAs Derived from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients: Functional Implication of miR-21 and Other Small RNAs in Cancer Malignancy: CANCERS. 13(2):209~ (6.639)
2020 SCI-E Development of a miRNA-controlled dual-sensing system and its application for targeting miR-21 signaling in tumorigenesis: EXPERIMENTAL AND MOLECULAR MEDICINE. 52(12):1989~2004 (5.418)
2020 SCI-E Nanoparticles in 472 human cerebrospinal fluid: Changes in extracellular vesicle concentration and miR-21 expression as a biomarker for leptomeningeal metastasis: CANCERS. 12(10):E2745~ (6.126)
2020 SCI-E Comparative cerebrospinal fluid metabolites profiling in glioma patients to predict malignant transformation and leptomeningeal metastasis with a potential for preventive personalized medicine: EPMA JOURNAL. Online:Published (4.901)
2020 SCI-E ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages: NATURE COMMUNICATIONS. 11(1):2978~ (12.121)
2020 SCI-E Dexamethasone Interferes with Autophagy and Affects Cell Survival in Irradiated Malignant Glioma Cells: JOURNAL OF KOREAN NEUROSURGICAL SOCIETY. Online:Published (1.376)
2019 SCI Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells: CANCER RESEARCH. 79(7):1369~1382 (8.378)
2018 SCI Poly(A)-specific ribonuclease sculpts the 3′ ends of microRNAs: RNA. 25(3):388~405 (4.49)
2017 SCI-E Cerebrospinal fluid metabolomic profiles can discriminate patients with leptomeningeal carcinomatosis from patients at high risk for leptomeningeal metastasis: Oncotarget. 8(60):101203~101214 (5.168)
2017 SCI The novel resveratrol derivative 3,5-diethoxy-3',4'-dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro.: Acta pharmacologica Sinica. 38(11):1486~1500 (3.223)
2017 SCI Transglutaminase 2 inhibition reverses mesenchymal transdifferentiation of glioma stem cells by regulating C/EBPβ signaling: Cancer Research. 77(18):4973~4984 (9.122)
2017 SCI CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis: Scientific Reports. 7(1):10666~10666 (4.259)
2017 SCI-E Inactivation of human DGAT2 by oxidative stress on cysteine residues: PLoS ONE. 12(7):e0181076~e0181076 (2.806)
2017 SCI-E C1QBP is upregulated in colon cancer and binds to apolipoprotein A-I: Experimental and Therapeutic Medicine. 13(5):2493~2500 (1.261)
2017 SCI-E Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116: Oncotarget. 8(4):6819~6823 (5.008)
2016 SCI-E TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling: Oncotarget. 7(48):79854~79868 (5.008)
2016 SCI-E AMP-activated protein kinase is involved in the activation of the Fanconi anemia/BRCA pathway in response to DNA interstrand crosslinks: Oncotarget. 7(33):53642~53653 (5.008)
2016 SCI-E Antiviral activity of micafungin against enterovirus 71: Virology Journal. 13:99~99 (2.362)
2015 SCI DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis: Brain. 138(Pt9):2553~2570 (9.196)
2015 SCI Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells: PLoS biology. 13(5):1002152~1002152 (9.343)
2015 SCI-E Radiation-induced autophagy contributes to cell death and induces apoptosis partly in malignant glioma cells.: Cancer research and treatment. 47(2):221~241 (3.318)
2014 SCI-E CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression: Oncotarget. 5(16):6756~6769 (6.627)
2014 SCI Regulation of Diacylglycerol Acyltransferase 2 (DGAT2) Protein Stability by gp78-Associated ER-associated degradation (ERAD): The FEBS journal. 281(13):3048~3060 (3.986)
2014 SCI The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein: Biochimica et biophysica acta-Gene Regulatory Mechanisms. 1839(5):374~386 (5.44)
2014 기타 Roles of Long Non-Coding RNAs on Tumorigenesis and Glioma Development: Brain tumor research and treatment. 2(1):1~6 (0)
2014 SCI-E Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells: BMC Cancer. 14:160~160 (3.319)
2013 SCI Adenosine dialdehyde suppresses MMP-9-mediated invasion of cancer cells by blocking the Ras/Raf-1/ERK/AP-1 signaling pathway: Biochemical Pharmacology. 86(9):1285~1300 (4.576)
2013 SCI-E AP-1/IRF-3 Targeted Anti-Inflammatory Activity of Andrographolide Isolated from Andrographis paniculata: Evid Based Complement Alternat Med.. 2013:210736~210736 (1.722)
2012 SCI-E Silencing of MicroRNA-21 Confers Radio-Sensitivity through Inhibition of the PI3K/AKT Pathway and Enhancing Autophagy in Malignant Glioma Cell Lines.: PLOS ONE. 7(10):e47449~e47449 (4.092)
2012 SCI Bidirectional Control of mRNA Translation and Synaptic Plasticity by the Cytoplasmic Polyadenylation Complex: Molecular Cell. 47(2):253~266 (14.178)
2011 SCI-E PTEN Modulates miR-21 Processing via RNA-Regulatory Protein RNH1: PLoS ONE. 6(12):e28308~e28308 (4.411)
2011 SCI Translation-competent 48S complex formation on HCV IRES requires the RNA-binding protein NSAP1: Nucleic Acids Research. 39(17):7791~7802 (7.836)
2011 SCI Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas: Oncogene. 30(21):2433~2442 (7.414)
2008 SCI Measuring CPEB-Mediated Cytoplasmic Polyadenylation-Deadenylation in Xenopus laevis Oocytes and Egg Extracts: Methods in Enzymology. 448:119~138 (2.122)
2008 SCI An RNA-binding protein hnRNP D modulates IRES-dependent translation of HCV RNA: Journal of Virology. 82:12082~12093 (5.332)
2007 SCI BiP IRES activity is controlled by heat-induced interaction of NSAP1: Molecular and Cellular Biology. 27:368~383 (7.822)
2007 SCI RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB: Genes & Development. 21:2571~2579 (17.01)
2006 SCI Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation: Molecular Cell. 24:173~183 (16.811)
2006 SCI PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals: Celluar Signalling. 18:2283~2291 (4.741)
2006 SCI Oscillating Cdk1 and Calcineurin Activities Regulate Maskin Association with eIF4E, Cyclin B1 mRNA Translation, and Cell Cycle Progression: Nature Structural & Molecular Biology. 13:1128~1134 (12)
2005 SCI Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase: Molecular and Cellular Biology. 25:1283~1297 (7.822)
2005 SCI Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation: Molecular and Cellular Biology. 25:3232~3246 (7.822)
2004 SCI Identification of cellular proteins enhancing activities of internal ribosomal entry sites by competition with oligodeoxynucleotides: Nucleic Acids Research. 32:1308~1317 (7.26)
2004 SCI A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon: Molecular and Cellular Biology. 24:7878~7890 (7.822)
2003 SCI Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner: Molecular and Cellular Biology. 23:708~720 (7.822)
2000 SCI Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm: Journal of Molecular Biology. 298:395~405 (5.826)
1998 SCI Polypyrimidine tract-binding protein interacts with hnRNP L: FEBS Letters. 425:401~406 (3.843)
1998 SCI Heterogeneous nuclear ribonucleoprotein L interacts with the 3' border of the internal ribosomal entry site of hepatitis C virus: Journal of Virology. 72:8782~8788 (5.398)
