Faculty Directory
- Name
- Anders Lindroth, Ph.D.(full-time professor)
- Faculty Appointment
(title, department)
- Professor, Department of Cancer Biomedical Science, NCC-GCSP
- Area of Expertise
- Cancer Genetics and Epigenomics
- E-mail
- lindroth@ncc.re.kr
- Work Experience
- Researcher, DKFZ – German Cancer Research Center, Heidelberg, Germany (2011-2014)
Adjunct Lecturer, Animal Breeding and Genetics, SLU – Swedish University of Agricultural Sciences, Uppsala, Sweden (2009-2010)
Research Associate, Department of Molecular Biology and Microbiology, Uppsala University, Uppsala, Sweden (2008)
Postdoctoral Research Associate, Cornell University, Nutritional Sciences, Ithaca, USA (2004-2008)
Postdoctoral Researcher, Molecular, Cell & Developmental Biology, UCLA - University of California, Los Angeles, USA (2000-2004)
- Educational Background
- Ph.D., SLU - Swedish University of Agricultural Sciences (2000)
B.Sc., Uppsala University, Uppsala, Sweden
- Research Interests (Please place in paragraph form)
- Our research focus on tumor-related epigenetic dysregulation, both as active and passive contributor of tumorigenesis. Since epigenetic modifications in large part serve the purpose of fine-tuning transcriptional processes, protect the genome, anchor the chromosomal regions to various compartments of the nucleus, and to locally and globally orchestrate coordinated gene expressions by modifying critical control elements of the genome, we strive to analyse individual epigenetic regulators in an as simple cytogenetic background as possible to reduce noice. Our study objects are therefore childhood tumors that provide the inner and most aggressive workings of neoplastic growth.
The goal of our research is to unravel epigenetic patterns that drive tumorigenesis and can be used as biomarkers in prevention and stratification of patients in the clinic.
Students interested in epigenetics and bioinformatics in all its aspects from model organisms to cancer are welcome to apply to our research group.
- International Collaboration
- Epigenomics of histone mutations in glioblastoma and giant cell tumor of the bone, with Prof. Dr. Christoph Plass and Prof. Dr. Stefan Pfister – German Cancer Research Center, Heidelberg (2014 - present).
Histone methylation affecting tumorigenesis in colorectal cancers, with Dr. Tobias Sjöblom – Rudbeck laboratory, Uppsala University, Sweden (2015 – present).
- Achievements
-
2020 SCI-E Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone.: NATURE COMMUNICATIONS. Online:Published (12.121)
2020 SCI-E The mechanistic GEMMs of oncogenic histones: HUMAN MOLECULAR GENETICS. 29(R2):R226~R235 (5.1)
2020 SCI-E EHMT2 Inhibition Induces Cell Death in Human Non-Small Cell Lung Cancer by Altering the Cholesterol Biosynthesis Pathway: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 21(3):1002~ (4.556)
2019 SCI Knock-down of oncohistone H3F3A-G34W counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells: CANCER LETTERS. 448:61~69 (6.508)
2018 SCI Transcriptome and protein interaction profiling in cancer cells with mutations in histone H3.3: SCIENTIFIC DATA. 5:10283~10283 (5.311)
2017 SCI Diet-induced obesity leads to metabolic dysregulation in offspring via endoplasmic reticulum stress in a sex-specific manner: International Journal of Obesity. 42(2):244~251 (5.487)
2017 SCI-E Somatic PRDM2 c.4467delA mutations in colorectal cancers control histone methylation and tumor growth: Oncotarget. 8(58):98646~98659 (5.168)
2017 SCI DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats: Nature Genetics. 49(7):1052~1060 (27.959)
2017 SCI The histone variant H3.3 G34W substitution in giant cell tumor of the bone link chromatin and RNA processing: Scientific reports. 7(1):13459~13459 (4.259)
2017 SCI-E Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial mesenchymal transition: BMC Cancer. 17:487~487 (3.288)
2017 SCI TET-mediated Hydroxymethylcytosine at the Pparγ Locus Is Required for Initiation of Adipogenic Differentiation: International Journal of Obesity. 41(4):652~659 (5.487)
2016 SCI-E Neuroprotective effects of Paeonia lactiflora extract against cell death of dopaminergic SH-SY5Y cells is mediated by epigenetic modulation: BMC Complementary and Alternative Medicine. 16:208~208 (1.987)
2015 기타 Epigenetic Reprogramming in Cancer: Epigenetic Mechanisms in Cellular Reprogramming. 31(4):193~223 (0)
2014 SCI PRC2 loss amplifies Ras signaling in cancer: Nature Genetics. 46(11):1154~1155 (29.648)
2014 SCI Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A: Molecular cell. 55(4):604~614 (14.464)
2014 SCI-E Relationship between genome and epigenome--challenges and requirements for future research.: BMC Genomics. 15:487~487 (4.041)
2013 SCI Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.: CANCER CELL. 24:660~672 (23.893)
2013 SCI Epigenetic biomarkers: a step forward for understanding periodontitis: JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE. 43:111~120 (1.145)
2013 SCI BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1: Nature Medicine. 19:901~908 (28.054)
2013 SCI Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer: NATURE REVIEWS GENETICS. 14:765~780 (39.794)
2013 SCI Recurrent H3.3 alterations in childhood tumors: NATURE GENETICS. 45:1413~1414 (29.648)
2013 SCI Alterations in cardiac DNA methylation in human dilated cardiomyopathy: EMBO Molecular Medicine. Online:Published (8.245)
2012 SCI Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.: CANCER CELL. 22:425~437 (23.893)
2012 SCI Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma: Nature. 482:226~231 (42.351)
2012 SCI Sequences Sufficient for Programming Imprinted Germline DNA Methylation Defined: PLOS ONE. Online:Published (3.534)
2010 기타 ZBED6: The birth of a new transcription factor in the common ancestor of placental mammals.: Transcription. 1:144~148 ()
2009 SCI ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.: PLOS Biology. Online:Published (12.916)
2008 SCI Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus.: PLOS Genetics. Online:Published (8.167)
2005 SCI Rasgrf1 imprinting is regulated by a CTCF-dependent methylation-sensitive enhancer blocker.: Molecular and Cellular Biology. 25:11184~11190 (5.036)
2005 SCI Chromatin and siRNA pathways cooperate to maintain DNA methylation of small transposable elements in Arabidopsis: Genome Biology. Online:Published (10.465)
2004 SCI Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3: The EMBO Journal. 23:4286~4296 (10.748)
2002 SCI Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase.: NATURE. 416:556~560 (42.351)
2001 SCI Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation: Science. 292:2077~2080 (33.611)
2001 SCI Two S-adenosylmethionine synthetase-encoding genes differentially expressed during adventitious root development in Pinus contorta: Plant Molecular Biology. 46:335~346 (4.072)
2001 SCI Isolation of a PSTAIRE CDC2 cDNA from Pinus contorta and its expression during adventitious root development: Plant Physiology and Biochemistry. 39:107~114 (2.352)
1999 SCI Ubiquitous and tissue specific gus expression in transgenic roots conferred by six different promoters in one coniferous and three angiosperm species.: Plant Cell Reports. 18:820~828 (2.936)
1996 기타 Agrobacterium rhizogenes-mediated induction of adventitious rooting from Pinus contorta hypocotyls and the effect of 5-azacytidine on transgene activity: Transgenic Research. 5:75~85 (2.281)
