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Park Mi Kyung

Park Mi Kyung
Faculty Appointment
(title, department)
Research associate professor Department of Cancer Biomedical Science, NCC-GCSP
Area of Expertise
Tumor metastasis
Contact no
Work Experience
Adjunct professor, College of Pharmacy, Dongguk University (Mar. 2020-)
Researcher, National Cancer Center (Oct.2008- Aug. 2017)
Educational Background
Ph.D. Pharmaceutical Biochemistry, Dongguk University (2013)
MS. Ecotoxicology, Korea University (2003)
B.A. Agricultural Biology, Korea University (2001)
Research Interests
Dr Park’s research interest focuses on investigation the role of cancer related genes and molecular mechanisms in tumor progression and metastasis. Her current research is epithelial-to-mesenchymal transition (EMT), Post-translational modification (PTM), Tumor microenvironment and mouse phenotype analysis in tumor. The final goal is to provide new insight into molecular mechanism and potential therapeutic approaches in cancer.
(Total: 53 SCI-E:48, 기타:5, Journal impact factor; # cites as of 2021)

2022 SCI-E Loss of EMP2 Inhibits Melanogenesis of MNT1 Melanoma Cells via Regulation of TRP-2. Biomolecules & Therapeutics.;30(2):203-211, 2022. (4.634)

2022 SCI-E PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells. International Journal of Molecular Sciences. 23(4): 2391-, 2022. (5.924)

2021 SCI-E Resolvin D1 Suppresses H2O2-Induced Senescence in Fibroblasts by Inducing Autophagy through the miR-1299/ARG2/ARL1 Axis. Antioxidants. 10(12): 1924-, 2021. (6.313)

2021 SCI-E LW1497, an Inhibitor of Malate Dehydrogenase, Suppresses TGF-β1-Induced Epithelial-Mesenchymal Transition in Lung Cancer Cells by Downregulating Slug. Antioxidants. 10(11): 1674-, 2021 (6.313)

2021 SCI-E NSD3-Induced Methylation of H3K36 Activates NOTCH Signaling to Drive Breast Tumor Initiation and Metastatic Progression. Cancer Research. 81(1): 77-90, 2021. (12.701)

2021 SCI-E Ethacrynic acid, a loop diuretic, suppresses epithelial-mesenchymal transition of A549 lung cancer cells via blocking of NDP-induced WNT signaling. Biochemical Pharmacology. 183:1-17, 2021. (5.858)

2020 SCI-E The catalytically defective receptor protein tyrosine kinase EphA10 promotes tumorigenesis in pancreatic cancer cells. Cancer Science. 111(9):3292-3302, 2020. (6.716)

2020 SCI-E SARNP, a participant in mRNA splicing and export, negatively regulates E-cadherin expression via interaction with pinin. Journal of Cellular Physiology. 235(2):1543-1555, 2020. (6.384)

2019 SCI-E Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment. Cancers, 11(11):1696, 2019. (6.639)

2019 SCI-E Loss of Mob1a/b impairs the differentiation of mouse embryonic stem cells into the three germ layer lineages. Experimental and Molecular Medicine. 51(11):1-12, 2019. (8.718)

2019 SCI-E CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1-ErbB-PI3K signaling. EMBO Reports. 20(10):e48058, 2019. (8.807)

2019 SCI-E YDJC Induces Epithelial-Mesenchymal Transition via Escaping from Interaction with CDC16 through Ubiquitination of PP2A. Journal of Oncology. 2019:1-25, 2019. (4.375)

2019 SCI-E Role of MEL-18 Amplification in Anti-HER2 Therapy of Breast Cancer. Journal of the National Cancer Institute. 111(6):609-619, 2019. (13.506)

2019 SCI-E TopBP1 deficiency impairs the localization of proteins involved in early recombination and results in meiotic chromosome defects during spermatogenesis. Biochemical and Biophysical Research Communications. 508(3):722-728, 2019. (3.575)

2018 기타 Mouse models of breast cancer in preclinical research. Laboratory Animal Research, 34(4):160-165, 2018. (0)

2018 SCI-E Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-beta signaling. Cell Death and Disease. 9(11):1083, 2018. (6.304)

2018 SCI-E AIMP3 depletion causes genome instability and loss of stemness in mouse embryonic stem cells. 9(10):972, 2018. (6.304)

2017 기타 YdjC chitooligosaccharide deacetylase homolog induces keratin reorganization in lung cancer cells: Involvement of interaction between YDJC and CDC16. Oncotarget. 9(33):22915-22928, 2017. (0)

2017 SCI-E Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2. Biomolecules & Therapeutics. 25(6):625-633, 2017. (4.634)

2017 SCI-E LSD1 demethylates HIF1 alpha to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis. Oncogene. 36(39):5512-5521, 2017. (9.867)

2017 SCI-E Novel involvement of miR-522-3p in high-mobility group box 1-induced prostaglandin reductase 1 expression and reduction of phagocytosis. Biochimica et Biophysica Acta-Molecular Cell Research. 1864(4):625-633, 2017. (4.739)

2017 기타 Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1. Oncotarget. 8(13):20851-20864, 2017. (0)

2016 SCI-E Effects of Cerulein on Keratin 8 Phosphorylation and Perinuclear Reorganization in Pancreatic Cancer Cells: Involvement of Downregulation of Protein Phosphatase 2A and Alpha4. Environmental Toxicology. 31(12):2090-2098, 2016. (4.119)

2016 SCI-E Leukotriene B4 induces EMT and vimentin expression in PANC-1 pancreatic cancer cells: Involvement of BLT2 via ERK2 activation. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 115:67-76, 2016. (4.006)

2016 SCI-E Novel effects of sphingosylphosphorylcholine on invasion of breast cancer: Involvement of matrix metalloproteinase-3 secretion leading to, WNT activation. Biochimica et Biophysica Acta-Molecular Basis Of Disease. 1862(9):1533-1543, 2016. (5.187)

2016 SCI-E Epithelial membrane protein 2 regulates sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization: Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung cancer cells. Biochimica et Biophysica Acta-Molecular Cell Research. 1863(6):1157-1169, 2016. (4.739)

2016 SCI-E Novel effects of FTY720 on perinuclear reorganization of keratin network induced by sphingosylphosphorylcholine: Involvement of protein phosphatase 2A and G-protein-coupled receptor-12. European Journal of Pharmacology. 775:86-95, 2016. (4.432)

2015 SCI-E UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1. EMBO Reports. 16(10):1288-1298, 2015. (8.807)

2015 SCI-E High-mobility group box 1 suppresses resolvin D1-induced phagocytosis via induction of resolvin D1-inactivating enzyme, 15-hydroxyprostaglandin dehydrogenase. Biochimica et Biophysica Acta-Molecular Basis of Disease. 1852(9):1981-1988, 2015. (5.187)

2015 SCI-E DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression. Nature Communications. 6:7821, 2015. (14.919)

2015 SCI-E Cardamonin Suppresses TGF-b1-Induced Epithelial Mesenchymal Transition via Restoring Protein Phosphatase 2A Expression. Biomolecules & Therapeutics. 23(2):141-148, 2015 (4.634).

2014 SCI-E Novel Suppressive Effects of Ketotifen on Migration and Invasion of MDA-MB-231 and HT-1080 Cancer Cells. Biomolecules & Therapeutics. 22(6):540-546, 2014. (4.634)

2014 SCI-E Novel inhibitory effects of cardamonin on thromboxane A(2)-induced scratching response: Blocking of G(h)/transglutaminase-2 binding to thromboxane A(2) receptor. Pharmacology Biochemistry and Behavior. 126:131-135, 2014.

2014 SCI-E Involvement of Transglutaminase-2 in alpha-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells. Biomolecules & Therapeutics. 22(3):207-212, 2014. (4.634)

2014 SCI-E 12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8 Phosphorylation and Reorganization via Expression of Transglutaminase-2. Biomolecules & Therapeutics. 22(2):122-128, 2014. (4.634)

2014 SCI-E Novel anti-nociceptive effects of cardamonin via blocking expression of cyclooxygenase-2 and transglutaminase-2. Pharmacology Biochemistry and Behavior. 118:10-15, 2014. (3.533)

2014 SCI-E Loss of the polycomb protein Mel-18 enhances the epithelial-mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer. Oncogene. 33(10):1325-1335, 2014. (9.867)

2013 SCI-E Resolvin D1 inhibits TGF-beta 1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32. International Journal of Biochemistry & Cell Biology. 45:2801-2807, 2013. (5.085)

2013 SCI-E Transglutaminase-2 induces N-cadherin expression in TGF-beta 1-induced epithelial mesenchymal transition via c-Jun-N-terminal kinase activation by protein phosphatase 2A. European Journal of Cancer, 49:1652-1705, 2013. (9.162)

2013 SCI-E Ethacrynic acid inhibits sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization via transglutaminase-2 inhibition. Biomolecules & Therapeutics. 21(5):338-342, 2013. (4.634)

2012 SCI-E Histamine receptor 2-mediated growth-differentiation factor-15 expression is involved in histamine-induced melanogenesis. International Journal of Biochemistry & Cell Biology. 44:2124-2128, 2012. (5.085)

2012 SCI-E Novel involvement of leukotriene B-4 receptor 2 through ERK activation by PP2A down-regulation in leukotriene B-4-induced keratin phosphorylation and reorganization of pancreatic cancer cells. Biochimica et Biophysica Acta-Molecular Cell Research. 1823:2120-2129, 2012. (4.739)

2012 SCI-E Metabolomic Investigation of the Anti-Platelet Aggregation Activity of Ginsenoside Rk(1) Reveals Attenuated 12-HETE Production. Journal of Proteome Research. 11:4939-4946, 2012. (4.466)

2012 SCI-E Suppression of Transglutaminase-2 is Involved in Anti-Inflammatory Actions of Glucosamine in 12-OTetradecanoylphorbol-13-Acetate-Induced Skin Inflammation. Biomolecules & Therapeutics. 20(4):380-385, 2012. (4.634)

2012 SCI-E Transglutaminase-2 Is Involved in All-Trans Retinoic Acid- Induced Invasion and Matrix Metalloproteinases Expression of SH-SY5Y Neuroblastoma Cells via NF-κB Pathway. Biomolecules & Therapeutics. 20(3):286-292, 2012. (4.634)

2011 SCI-E Serotonin induces melanogenesis via serotonin receptor 2A. British Journal of Dermatology. 165:1344-1348, 2011. (9.302)

2011 SCI-E Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells. Biochimica et Biophysica Acta-Molecular And Cell Biology of Lipids. 1811:1021-1029, 2011. (4.698)

2011 SCI-E Isolation of Soil Microorganisms Having Antibacterial Activity and Antimigratory Effects on Sphingosylphosphorylcholine-induced Migration of PANC-1 Cells. Toxicological research. 27(4):241-246, 2011. (3.43)

2011 SCI-E Expression of CYP2A6, CYP2D6 and CYP4A11 Polymorphisms in COS7 Mammalian Cell Line. Toxicological research. 27(1): 25-29, 2011. (3.43)

2011 SCI-E Sphingosylphosphorylcholine induces degranulation of mast cells in the skin and plasma exudation in the ears of mice. Journal of Dermatological Science. 57(1):57-59, 2010. (4.563)

2010 SCI-E Ethacrynic Acid and Citral Suppressed the All-Trans Retinoid-Induced Monocyte Chemoattractant Protein-1 Production in Human Dermal Fibroblasts. Biomolecules & Therapeutics. 18(1):71-76, 2010. (4.634)

2009 SCI-E Effect of nitrogen levels of two cherry tomato cultivars on development, preference and honeydew production of Trialeurodes vaporariorum (Hemiptera: Aleyrodidae). Journal of Asia-Pacific Entomology. 12(4):227-232, 2009. (1.303)

2007 SCI-E Effects of activin A on pancreatic ductal cells in streptozotocin-induced diabetic rats. Transplantation. 83(7):925-930, 2007. (4.939)

2007 기타 Activin A and glucose derived human pancreatic ductal cells into insulin-producing cells. Korean Diabetes Journal 2007;31(1):44-50, 2007. (0)

2007 기타 Activin A converts pancreatic ductal cells into insulin-secreting cells. Korean Diabetes Journal 2004;28(1):20-27, 2004. (0)