Faculty Directory
- Name
- Park Mi Kyung
- Faculty Appointment
(title, department)
-
Research associate professor Department of Cancer Biomedical Science, NCC-GCSP
- Area of Expertise
- Tumor metastasis
- Contact no
- +82-31-920-2265
- E-mail
- mkpark@ncc.re.kr
- Work Experience
-
Adjunct professor, College of Pharmacy, Dongguk University (Mar. 2020-)
Researcher, National Cancer Center (Oct.2008- Aug. 2017)
- Educational Background
-
Ph.D. Pharmaceutical Biochemistry, Dongguk University (2013)
MS. Ecotoxicology, Korea University (2003)
B.A. Agricultural Biology, Korea University (2001)
- Research Interests
-
Dr Park’s research interest focuses on investigation the role of cancer related genes and molecular mechanisms in tumor progression and metastasis. Her current research is epithelial-to-mesenchymal transition (EMT), Post-translational modification (PTM), Tumor microenvironment and mouse phenotype analysis in tumor. The final goal is to provide new insight into molecular mechanism and potential therapeutic approaches in cancer.
- Achievements
-
(Total: 53 SCI-E:48, 기타:5, Journal impact factor; # cites as of 2021)
2022 SCI-E Loss of EMP2 Inhibits Melanogenesis of MNT1 Melanoma Cells via Regulation of TRP-2. Biomolecules & Therapeutics.;30(2):203-211, 2022. (4.634)
2022 SCI-E PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells. International Journal of Molecular Sciences. 23(4): 2391-, 2022. (5.924)
2021 SCI-E Resolvin D1 Suppresses H2O2-Induced Senescence in Fibroblasts by Inducing Autophagy through the miR-1299/ARG2/ARL1 Axis. Antioxidants. 10(12): 1924-, 2021. (6.313)
2021 SCI-E LW1497, an Inhibitor of Malate Dehydrogenase, Suppresses TGF-β1-Induced Epithelial-Mesenchymal Transition in Lung Cancer Cells by Downregulating Slug. Antioxidants. 10(11): 1674-, 2021 (6.313)
2021 SCI-E NSD3-Induced Methylation of H3K36 Activates NOTCH Signaling to Drive Breast Tumor Initiation and Metastatic Progression. Cancer Research. 81(1): 77-90, 2021. (12.701)
2021 SCI-E Ethacrynic acid, a loop diuretic, suppresses epithelial-mesenchymal transition of A549 lung cancer cells via blocking of NDP-induced WNT signaling. Biochemical Pharmacology. 183:1-17, 2021. (5.858)
2020 SCI-E The catalytically defective receptor protein tyrosine kinase EphA10 promotes tumorigenesis in pancreatic cancer cells. Cancer Science. 111(9):3292-3302, 2020. (6.716)
2020 SCI-E SARNP, a participant in mRNA splicing and export, negatively regulates E-cadherin expression via interaction with pinin. Journal of Cellular Physiology. 235(2):1543-1555, 2020. (6.384)
2019 SCI-E Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment. Cancers, 11(11):1696, 2019. (6.639)
2019 SCI-E Loss of Mob1a/b impairs the differentiation of mouse embryonic stem cells into the three germ layer lineages. Experimental and Molecular Medicine. 51(11):1-12, 2019. (8.718)
2019 SCI-E CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1-ErbB-PI3K signaling. EMBO Reports. 20(10):e48058, 2019. (8.807)
2019 SCI-E YDJC Induces Epithelial-Mesenchymal Transition via Escaping from Interaction with CDC16 through Ubiquitination of PP2A. Journal of Oncology. 2019:1-25, 2019. (4.375)
2019 SCI-E Role of MEL-18 Amplification in Anti-HER2 Therapy of Breast Cancer. Journal of the National Cancer Institute. 111(6):609-619, 2019. (13.506)
2019 SCI-E TopBP1 deficiency impairs the localization of proteins involved in early recombination and results in meiotic chromosome defects during spermatogenesis. Biochemical and Biophysical Research Communications. 508(3):722-728, 2019. (3.575)
2018 기타 Mouse models of breast cancer in preclinical research. Laboratory Animal Research, 34(4):160-165, 2018. (0)
2018 SCI-E Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-beta signaling. Cell Death and Disease. 9(11):1083, 2018. (6.304)
2018 SCI-E AIMP3 depletion causes genome instability and loss of stemness in mouse embryonic stem cells. 9(10):972, 2018. (6.304)
2017 기타 YdjC chitooligosaccharide deacetylase homolog induces keratin reorganization in lung cancer cells: Involvement of interaction between YDJC and CDC16. Oncotarget. 9(33):22915-22928, 2017. (0)
2017 SCI-E Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2. Biomolecules & Therapeutics. 25(6):625-633, 2017. (4.634)
2017 SCI-E LSD1 demethylates HIF1 alpha to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis. Oncogene. 36(39):5512-5521, 2017. (9.867)
2017 SCI-E Novel involvement of miR-522-3p in high-mobility group box 1-induced prostaglandin reductase 1 expression and reduction of phagocytosis. Biochimica et Biophysica Acta-Molecular Cell Research. 1864(4):625-633, 2017. (4.739)
2017 기타 Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1. Oncotarget. 8(13):20851-20864, 2017. (0)
2016 SCI-E Effects of Cerulein on Keratin 8 Phosphorylation and Perinuclear Reorganization in Pancreatic Cancer Cells: Involvement of Downregulation of Protein Phosphatase 2A and Alpha4. Environmental Toxicology. 31(12):2090-2098, 2016. (4.119)
2016 SCI-E Leukotriene B4 induces EMT and vimentin expression in PANC-1 pancreatic cancer cells: Involvement of BLT2 via ERK2 activation. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 115:67-76, 2016. (4.006)
2016 SCI-E Novel effects of sphingosylphosphorylcholine on invasion of breast cancer: Involvement of matrix metalloproteinase-3 secretion leading to, WNT activation. Biochimica et Biophysica Acta-Molecular Basis Of Disease. 1862(9):1533-1543, 2016. (5.187)
2016 SCI-E Epithelial membrane protein 2 regulates sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization: Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung cancer cells. Biochimica et Biophysica Acta-Molecular Cell Research. 1863(6):1157-1169, 2016. (4.739)
2016 SCI-E Novel effects of FTY720 on perinuclear reorganization of keratin network induced by sphingosylphosphorylcholine: Involvement of protein phosphatase 2A and G-protein-coupled receptor-12. European Journal of Pharmacology. 775:86-95, 2016. (4.432)
2015 SCI-E UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1. EMBO Reports. 16(10):1288-1298, 2015. (8.807)
2015 SCI-E High-mobility group box 1 suppresses resolvin D1-induced phagocytosis via induction of resolvin D1-inactivating enzyme, 15-hydroxyprostaglandin dehydrogenase. Biochimica et Biophysica Acta-Molecular Basis of Disease. 1852(9):1981-1988, 2015. (5.187)
2015 SCI-E DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression. Nature Communications. 6:7821, 2015. (14.919)
2015 SCI-E Cardamonin Suppresses TGF-b1-Induced Epithelial Mesenchymal Transition via Restoring Protein Phosphatase 2A Expression. Biomolecules & Therapeutics. 23(2):141-148, 2015 (4.634).
2014 SCI-E Novel Suppressive Effects of Ketotifen on Migration and Invasion of MDA-MB-231 and HT-1080 Cancer Cells. Biomolecules & Therapeutics. 22(6):540-546, 2014. (4.634)
2014 SCI-E Novel inhibitory effects of cardamonin on thromboxane A(2)-induced scratching response: Blocking of G(h)/transglutaminase-2 binding to thromboxane A(2) receptor. Pharmacology Biochemistry and Behavior. 126:131-135, 2014.
2014 SCI-E Involvement of Transglutaminase-2 in alpha-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells. Biomolecules & Therapeutics. 22(3):207-212, 2014. (4.634)
2014 SCI-E 12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8 Phosphorylation and Reorganization via Expression of Transglutaminase-2. Biomolecules & Therapeutics. 22(2):122-128, 2014. (4.634)
2014 SCI-E Novel anti-nociceptive effects of cardamonin via blocking expression of cyclooxygenase-2 and transglutaminase-2. Pharmacology Biochemistry and Behavior. 118:10-15, 2014. (3.533)
2014 SCI-E Loss of the polycomb protein Mel-18 enhances the epithelial-mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer. Oncogene. 33(10):1325-1335, 2014. (9.867)
2013 SCI-E Resolvin D1 inhibits TGF-beta 1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32. International Journal of Biochemistry & Cell Biology. 45:2801-2807, 2013. (5.085)
2013 SCI-E Transglutaminase-2 induces N-cadherin expression in TGF-beta 1-induced epithelial mesenchymal transition via c-Jun-N-terminal kinase activation by protein phosphatase 2A. European Journal of Cancer, 49:1652-1705, 2013. (9.162)
2013 SCI-E Ethacrynic acid inhibits sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization via transglutaminase-2 inhibition. Biomolecules & Therapeutics. 21(5):338-342, 2013. (4.634)
2012 SCI-E Histamine receptor 2-mediated growth-differentiation factor-15 expression is involved in histamine-induced melanogenesis. International Journal of Biochemistry & Cell Biology. 44:2124-2128, 2012. (5.085)
2012 SCI-E Novel involvement of leukotriene B-4 receptor 2 through ERK activation by PP2A down-regulation in leukotriene B-4-induced keratin phosphorylation and reorganization of pancreatic cancer cells. Biochimica et Biophysica Acta-Molecular Cell Research. 1823:2120-2129, 2012. (4.739)
2012 SCI-E Metabolomic Investigation of the Anti-Platelet Aggregation Activity of Ginsenoside Rk(1) Reveals Attenuated 12-HETE Production. Journal of Proteome Research. 11:4939-4946, 2012. (4.466)
2012 SCI-E Suppression of Transglutaminase-2 is Involved in Anti-Inflammatory Actions of Glucosamine in 12-OTetradecanoylphorbol-13-Acetate-Induced Skin Inflammation. Biomolecules & Therapeutics. 20(4):380-385, 2012. (4.634)
2012 SCI-E Transglutaminase-2 Is Involved in All-Trans Retinoic Acid- Induced Invasion and Matrix Metalloproteinases Expression of SH-SY5Y Neuroblastoma Cells via NF-κB Pathway. Biomolecules & Therapeutics. 20(3):286-292, 2012. (4.634)
2011 SCI-E Serotonin induces melanogenesis via serotonin receptor 2A. British Journal of Dermatology. 165:1344-1348, 2011. (9.302)
2011 SCI-E Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells. Biochimica et Biophysica Acta-Molecular And Cell Biology of Lipids. 1811:1021-1029, 2011. (4.698)
2011 SCI-E Isolation of Soil Microorganisms Having Antibacterial Activity and Antimigratory Effects on Sphingosylphosphorylcholine-induced Migration of PANC-1 Cells. Toxicological research. 27(4):241-246, 2011. (3.43)
2011 SCI-E Expression of CYP2A6, CYP2D6 and CYP4A11 Polymorphisms in COS7 Mammalian Cell Line. Toxicological research. 27(1): 25-29, 2011. (3.43)
2011 SCI-E Sphingosylphosphorylcholine induces degranulation of mast cells in the skin and plasma exudation in the ears of mice. Journal of Dermatological Science. 57(1):57-59, 2010. (4.563)
2010 SCI-E Ethacrynic Acid and Citral Suppressed the All-Trans Retinoid-Induced Monocyte Chemoattractant Protein-1 Production in Human Dermal Fibroblasts. Biomolecules & Therapeutics. 18(1):71-76, 2010. (4.634)
2009 SCI-E Effect of nitrogen levels of two cherry tomato cultivars on development, preference and honeydew production of Trialeurodes vaporariorum (Hemiptera: Aleyrodidae). Journal of Asia-Pacific Entomology. 12(4):227-232, 2009. (1.303)
2007 SCI-E Effects of activin A on pancreatic ductal cells in streptozotocin-induced diabetic rats. Transplantation. 83(7):925-930, 2007. (4.939)
2007 기타 Activin A and glucose derived human pancreatic ductal cells into insulin-producing cells. Korean Diabetes Journal 2007;31(1):44-50, 2007. (0)
2007 기타 Activin A converts pancreatic ductal cells into insulin-secreting cells. Korean Diabetes Journal 2004;28(1):20-27, 2004. (0)
