교수진 소개
- Name
- Dongkwan SHIN, Ph.D.
- Faculty Appointment:
(title, department)
- Associate professor, Department of Cancer Biomedical Science, NCC-GCSP
Senior Scientist, Bioinformatics Branch, Division of Cancer Data Science, Research Institute, National Cancer Center
- Area of Expertise
- Cancer Systems Biology, Bioinformatics, Network biology
- Contact no
- +82-31-920-2433
- E-mail
- dshin@ncc.re.kr
- Work Experience
- Sep 2020 - : Senior Scientist, Research Institute, National Cancer Center
Apr 2014 – Aug 2020: Research Assistant/Associate Professor, Department of Bio and Brain Engineering, KAIST
Sep 2007 – Mar 2014: Postdoctoral Fellow, Information & Electronics Research Institute, KAIST
Mar 2007 – Aug 2007: Postdoctoral Fellow, Bio-MAX Institute, Seoul National University
- Educational Background
- Mar 2000 – Feb 2007: Ph.D., Department of Physics, Seoul National University
Mar 1994 – Aug 1999: B.S., Department of Physics, Sogang University
- Research Interests
- Dynamic network modeling of cancer cells
Prediction of novel therapeutic targets by single cell data analysis
Cancer prevention research with cancer transition analysis
- Achievements
-
D. Shin and K.-H. Cho, “Critical transition and reversion of tumorigenesis”, Experimental & Molecular Medicine, 55, 692 (2023)
J. I. Joo, M. Choi, S.-H. Jang, S. Choi, S.-M. Park, D. Shin, and K.-H. Cho, " Realizing cancer precision medicine by integrating systems biology and nanomaterial engineering", Advanced Materials, 55, 692, (2020)
S.-Y. Yeo*, K.-W. Lee*, D. Shin*, S. An, K.-H. Cho, and S.-H. Kim, "A positive feedback loop bi-stably activates fibroblasts", Nature Communications, 9, 3016, (2018) (* equally contributed)
B. Lee, D. Shin, S. P. Gross, and K.-H. Cho, "Combined positive and negative feedback allows modulation of neuronal oscillation frequency during sensory processing", Cell Reports, 25, 6, (2018)
D. Shin, J. Lee, J.-R. Gong, and K.-H. Cho, “Percolation transition of cooperative mutational effects in colorectal tumorigenesis”, Nature Communications, 8, 1270 (2017)
Y. Kim, S. Choi, D. Shin, K.-H. Cho, “Quantitative evaluation and reversion analysis of the attractor landscapes of an intracellular regulatory network for colorectal cancer”, BMC Systems Biology, 11, 45 (2017)
K.-H. Cho, S. Lee, D. Kim, D. Shin, J. I. Joo, and S.-M. Park, "Cancer reversion, a renewed challenge in systems biology", Current Opinion in Systems Biology, 2, 48 (2017).
K.-H. Cho, J. I. Joo, D. Shin, D. Kim, and S.-M. Park, "The reverse control of irreversible biological processes", WIREs Systems Biology and Medicine, 8, 366 (2016).
D. Shin, I. S. Kim, J. M. Lee, S.-Y. Shin, J.-H. Lee, S. H. Baek, and K.-H. Cho, "The hidden switches underlying RORalpha-mediated circuits that critically regulate uncontrolled cell proliferation", Journal of Molecular Cell Biology, 6, 338 (2014).
D. Shin and K.-H. Cho, "Recurrent connections form a phase-locking neuronal tuner for frequency-dependent selective communication", Scientific Reports (Nature Publishing Group), 3 (2223), 1-9 (2013).
K. Noh, K. S. Shin, D. Shin, J. Y. Hwang, J. S. Kim, J. H. Jang, C. K. Chung, J. S. Kwon, and K.-H. Cho, "Impaired coupling of local and global functional feedbacks underlies abnormal synchronization and negative symptoms of Schizophrenia", BMC Systems Biology, 7, 30 (2013).
K. Jhung, S.-H. Cho, J.-H. Jang, J. Y. Park, D. Shin, K. R. Kim, E. Lee, K.-H. Cho, S. K. An, "Small-world networks in individuals at ultra-high risk for psychosis and first-episode schizophrenia during a working memory task", Neuroscience Letter, 535, 35-39 (2013).
C.-Y. Dong, D. Shin, S. Joo, Y. Nam, K.-H. Cho, "Identification of feedback loops in neural networks based on multi-step Granger causality", Bioinformatics, 28, 2146 (2012).
J.-R. Kim, D. Shin, S.H. Jung, P. Heslop-Harrison, and K.-H. Cho, “A design principle underlying the synchronization of oscillations in cellular systems”, Journal of Cell Science, 123, 537 (2010).
H. Oymak, D. Shin, and J. Hong, “Time-Dependent Phonon-Assisted Tunneling through a Single-Molecular Device: Ricatti Matrix Approach”, EPL (Europhysics Letters), 77, Art. No. 37005 (2007).
D. Shin, H. Oymak, and J. Hong, “Phonon-photon-assisted tunneling through an Aharonov-Bohm ring”, Journal of Physics Condensed Matter, 19(22), Art. No. 226211 (2007).
D. Shin and J. Hong, “Momentum filtering by photon-assisted tunneling in a connected Aharonov-Bohm ring”, Phys. Rev. B 72, 113307 (2005).
D. Shin and J. Hong, “Electron transport in the Aharonov-Bohm pump”, Phys. Rev. B 70, 073301 (2004).
M. D. Kim, D. Shin, and J. Hong, “Scalable quantum computing using persistent current qubits with Josephson junctions”, Physica E 18, 45 (2003).
M. D. Kim, D. Shin, and J. Hong, “Double-well potentials in current qubits”, Phys. Rev. B 68, 134513 (2003).
