교수진 소개
- Name
- Jong Bae PARK, Ph.D.
- Faculty Appointment
- Professor, Department of Cancer Biomedical Science
- Area of Expertise
- Cell Biology/Tumor microenvironment
- E-mail
- jbp@ncc.re.kr
- Work Experience
- Post-doctoral fellow, Division of Neuroscience, Harvard medical school.
Department Chair, National Cancer Center Graduate School of Cancer Science and Policy
Dean, National Cancer Center Graduate School of Cancer Science and Policy
- Educational Background
- Ph.D. Life Science, POSTECH (2001)
M.S. Life Science, POSTECH (1998)
B.S. Gyeongsang National University (1994)
- Research Interests
- Dr. Park is an associate professor of system cancer science at GSCP. His research focuses on tumor microenvironment which is critical for the cancer stem cell proliferation and infiltration. He is also involved in several research projects on the development of anti-cancer drug targeting tumor microenvironment.
- International Collaboration
- Glioma stem cell invasion, Cleveland clinic (2010-present)
Induced glioma stem cell, Keio University (2012–present)
siRNA delivery, National Cancer Center, Japan (2009-present)
- Achievements
-
2021 SCI-E Exploratory Profiling of Extracellular microRNAs in Cerebrospinal Fluid Comparing Leptomeningeal Metastasis with Other Central Nervous System Tumor Statuses: JOURNAL OF CLINICAL MEDICINE. 10(21):4860~ (4.242)
2021 SCI-E Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP downregulates stemness phenotype and mesenchymal trans-differentiation after irradiation in glioblastoma multiforme: PLOS ONE. 16(9):e0257375~ (3.24)
2021 SCI-E Analysis of electric cigarette liquid effect on mouse brain tumor growth through EGFR and ERK activation: PLOS ONE. 16(9):e0256730~ (3.24)
2021 SCI-E Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma: BRAIN. 144(2):636~654 (13.501)
2021 SCI-E Molecular Signature of Extracellular Vesicular Small Non-Coding RNAs Derived from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients: Functional Implication of miR-21 and Other Small RNAs in Cancer Malignancy: CANCERS. 13(2):209~ (6.639)
2020 SCI-E Development of a miRNA-controlled dual-sensing system and its application for targeting miR-21 signaling in tumorigenesis: EXPERIMENTAL AND MOLECULAR MEDICINE. 52(12):1989~2004 (5.418)
2020 SCI-E Anti-Tumor Effects of Sodium Meta-Arsenite in Glioblastoma Cells with Higher Akt Activities: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 21(23):8982~ (4.556)
2020 SCI-E Nanoparticles in 472 human cerebrospinal fluid: Changes in extracellular vesicle concentration and miR-21 expression as a biomarker for leptomeningeal metastasis: CANCERS. 12(10):E2745~ (6.126)
2020 SCI-E Targeting Oxidative Phosphorylation Reverses Drug Resistance in Cancer Cells by Blocking Autophagy Recycling: CELLS. 9(9):2013~ (4.366)
2020 SCI-E Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma: GENOME BIOLOGY. 21(1):216~ (10.806)
2020 기타 An Asian Perspective of the Management of COVID-19: the Asian National Cancer Centers Alliance Led Regional Comparison: Asian Pacific Journal of Cancer Care. 5 (Suppl 1):27~42 (0)
2020 SCI-E Comparative cerebrospinal fluid metabolites profiling in glioma patients to predict malignant transformation and leptomeningeal metastasis with a potential for preventive personalized medicine: EPMA JOURNAL. Online:Published (4.901)
2020 SCI-E ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages: NATURE COMMUNICATIONS. 11(1):2978~ (12.121)
2020 기타 An Asian Body to Tackle Cancers in Asia - The Asian National Cancer Centers Alliance: Asian Pacific Journal of Cancer Prevention. 21(5):1207~1212 (0)
2020 SCI-E Dexamethasone Interferes with Autophagy and Affects Cell Survival in Irradiated Malignant Glioma Cells: JOURNAL OF KOREAN NEUROSURGICAL SOCIETY. Online:Published (1.376)
2020 SCI-E STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model: CELLS. 9(3):722~ (4.366)
2020 SCI-E Charge Conversional Biomimetic Nanocomplexes as a Multifunctional Platform for Boosting Orthotopic Glioblastoma RNAi Therapy: NANO LETTERS. 20(3):1637~1646 (11.238)
2020 SCI-E Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1: EXPERIMENTAL AND MOLECULAR MEDICINE. 52(1):79~91 (5.418)
2019 SCI Nogo receptor-vimentin interaction: a novel mechanism for the invasive activity of glioblastoma multiforme: EXPERIMENTAL & MOLECULAR MEDICINE. Online:Published (4.743)
2019 SCI Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway: MOLECULES AND CELLS. 42(8):604~616 (3.533)
2019 SCI-E ROS-Responsive Polymeric siRNA Nanomedicine Stabilized by Triple Interactions for the Robust Glioblastoma Combinational RNAi Therapy: ADVANCED MATERIALS. Online:Published (25.809)
2019 SCI-E Apoptotic cell clearance in the tumor microenvironment: a potential cancer therapeutic target: ARCHIVES OF PHARMACAL RESEARCH. Online:Published (2.458)
2019 SCI Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells: CANCER RESEARCH. 79(7):1369~1382 (8.378)
2019 SCI-E Clinical outcome of cerebrospinal fluid shunts in patients with leptomeningeal carcinomatosis: WORLD JOURNAL OF SURGICAL ONCOLOGY. 17(1):59~59 (1.966)
2019 SCI-E Interplay betwwen TRAP1 and Sirtuil-3 modulates mitochondria respiration and oxidative stress to maintain stemness of gliblastoma stem cells: CANCER RESEARCH. 79(7):1369~1382 (9.727)
2018 SCI LPA-induced migration of ovarian cancer cells requires activation of ERM proteins via LPA1 and LPA2: Cellular Signalling. : (3.487)
2018 SCI An anti-EGFR?×?cotinine bispecific antibody complexed with cotinine-conjugated duocarmycin inhibits growth of EGFR-positive cancer cells with KRAS mutations: EXPERIMENTAL & MOLECULAR MEDICINE. : (5.584)
2018 SCI Proinvasive extracellular matrix remodeling in tumor microenvironment in response to radiation: ONCOGENE. : (6.854)
2018 SCI-E Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality: JOURNAL OF EXPERIMENTAL MEDICINE. : (10.892)
2018 SCI-E Kaposi's Sarcoma-Associated Herpesvirus Infection Modulates the Proliferation of Glioma Stem-Like Cells: JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY. : (1.65)
2018 SCI Allosteric inhibition site of transglutaminase 2 is unveiled in the N terminus: Amino acids. 50(11):1583~1594 (2.906)
2018 SCI LPA-induced migration of ovarian cancer cells requires activation of ERM proteins via LPA1 and LPA2: Cellular Signalling. 44:138~147 (3.487)
2017 SCI A point mutation in the heavy chain complementarity-determining region 3 (HCDR3) significantly enhances the specificity of an anti-ROS1 antibody: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. : (2.559)
2017 SCI Inhibition of BMP signaling overcomes acquired resistance to cetuximab in oral squamous cell carcinomas: Cancer Letters. 414:181~189 (6.375)
2017 SCI-E Cerebrospinal fluid metabolomic profiles can discriminate patients with leptomeningeal carcinomatosis from patients at high risk for leptomeningeal metastasis: Oncotarget. 8(60):101203~101214 (5.168)
2017 SCI The histone variant H3.3 G34W substitution in giant cell tumor of the bone link chromatin and RNA processing: Scientific reports. 7(1):13459~13459 (4.259)
2017 SCI Transglutaminase 2 inhibition reverses mesenchymal transdifferentiation of glioma stem cells by regulating C/EBPβ signaling: Cancer Research. 77(18):4973~4984 (9.122)
2017 SCI Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation.: Experimental & Molecular Medicine. 49(7):e351~e351 (5.063)
2017 SCI Preclinical development of a humanized neutralizing antibody targeting HGF: Experimental & Molecular Medicine. 49(3):e309~e309 (5.063)
2016 SCI-E TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling: Oncotarget. 7(48):79854~79868 (5.008)
2016 SCI Histone variant H3F3A promotes lung cancer cell migration through intronic regulation: Nature Communications. 7:12914~12914 (11.329)
2015 SCI DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis: Brain. 138(Pt9):2553~2570 (9.196)
2015 SCI Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells: PLoS biology. 13(5):1002152~1002152 (9.343)
2015 SCI Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes: Cell death and differentiation. 22(4):665~676 (8.184)
2015 SCI-E Radiation-induced autophagy contributes to cell death and induces apoptosis partly in malignant glioma cells.: Cancer research and treatment. 47(2):221~241 (3.318)
2015 SCI Synthesis and biological evaluation of new pyrazol-4-ylpyrimidine derivatives as potential ROS1 kinase inhibitors: European journal of medicinal chemistry. 90:195~208 (3.447)
2014 SCI Tumoral RANKL activates astrocytes that promote glioma cell invasion through cytokine signaling.: Cancer letters. 353(2):194~200 (5.016)
2014 SCI-E CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression: Oncotarget. 5(16):6756~6769 (6.627)
2014 SCI Crosstalk between glioma-initiating cells and endothelial cells drives tumor progression: Cancer research. 74(16):4482~4492 (9.284)
2014 SCI The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein: Biochimica et biophysica acta-Gene Regulatory Mechanisms. 1839(5):374~386 (5.44)
2014 기타 Roles of Long Non-Coding RNAs on Tumorigenesis and Glioma Development: Brain tumor research and treatment. 2(1):1~6 (0)
2012 SCI Phospholipase signalling networks in cancer: Nature Reviews Cancer. 12(11):782~792 (37.545)
2012 SCI-E Silencing of MicroRNA-21 Confers Radio-Sensitivity through Inhibition of the PI3K/AKT Pathway and Enhancing Autophagy in Malignant Glioma Cell Lines.: PLOS ONE. 7(10):e47449~e47449 (4.092)
2012 SCI Hypoxia-induced up-regulation of apelin is associated with a poor prognosis in oral squamous cell carcinoma patients: Oral Oncology. 48(6):500~506 (2.857)
2012 SCI Interferon regulatory factor 7 regulates glioma stem cells via interleukin-6 and Notch signalling.: Brain. 135(4):1055~1069 (9.457)
2011 SCI-E PTEN Modulates miR-21 Processing via RNA-Regulatory Protein RNH1: PLoS ONE. 6(12):e28308~e28308 (4.411)
2011 SCI Human Brain Endothelial Cell-derived COX-2 Facilitates Extravasation of Breast Cancer Cells across the Blood-brain Barrier: Anticancer Research. 31(12):4307~4313 (1.656)
2011 SCI Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas: Oncogene. 30(21):2433~2442 (7.414)
2009 SCI Recruitment of Sprouty1 to immune synapse regulates T cell receptor signaling: Journal of Immunology. 183:7178~7186 (6)
2009 SCI HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress.: carcinogenesis. 30:1997~2004 (4.93)
2008 SCI 17-Allylamino-17-Demethoxygeldanamycin Down-Regulates Hyaluronic Acid-Induced Glioma Invasion by Blocking Matrix Metalloproteinase-9 Secretion: Molecular Cancer Research. 6:1657~1665 (4.317)
2008 SCI The role of Kalirin9 in p75/nogo receptor-mediated RhoA activation in cerebellar granule neurons: Journal of Biological Chemistry. 283:24690~24697 (5.581)
2006 SCI Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology: Nature. 442:814~817 (28.638)
2006 SCI The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis: Nature Cell Biology. 8:477~484 (17.623)
2005 SCI A TNF receptor family member TROY is a co-receptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors: Neuron. 45:345~351 (13.41)
2005 SCI EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans: Science. 310:106~110 (26.372)
2003 SCI Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition: Neuron. 38:177~185 (13.41)
