교수진 소개 │ 교육 │ GCSP

교수진

교수진 소개

Geon Kook LEE

Name: Geon Kook LEE, M.D., Ph.D. (adjunct professor)
Faculty Appointment (title, department): Professor, Department of Cancer Biomedical Science
Area of Expertise: Pulmonary Pathology
E-mail: gklee@ncc.re.kr

Work Experience: Director, Office of Public Relations and Collaboration(2014-present)
Head, Tumor Tissue Bank(2007-present)
Chief Scientist, Lung Cancer Branch(2007-present)
Educational Background: Ph.D., Seoul National University Graduate School of Medicine
M.S., Seoul National University Graduate School of Medicine
M.D., Seoul National University College of Medicine
Research Interests (Please place in paragraph form): My research interests include molecular classification and molecular diagnostics in lung cancers, mediastinal tumors and esophageal cancers, and development of new biomarkers for the lung cancers.

I am also interested in ethical, legal and practical issues related to biorepositories, especially human tumor repository.
International Collaboration: Member, International Academy of Pathology
Member, International Association for the Study of Lung Cancer
Member, Asia-Pacific Pulmonary Pathology Society
Achievements: 2021 SCI-E Long-Term Survival According to N Stage Diagnosed by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Non-Small Cell Lung Cancer: CHEST. Online:Published (9.41)

2021 SCI-E The Clinical Impact of Capmatinib in the Treatment of Advanced Non-Small Cell Lung Cancer with MET Exon 14 Skipping Mutation or Gene Amplification: CANCER RESEARCH AND TREATMENT. Online:Published (4.679)

2021 SCI-E A fusion of CD63?BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis: BRITISH JOURNAL OF CANCER. 124(1):290~290 (5.791)

2020 SCI-E Size and extranodal extension of metastatic lymph nodes in lung adenocarcinoma: JOURNAL OF THORACIC DISEASE. 12(11):6514~6522 (2.046)

2020 SCI-E Phase II Study of Pemetrexed as a Salvage Chemotherapy for Thymidylate Synthase-Low Squamous Cell Lung Cancer: CANCER RESEARCH AND TREATMENT. Online:Published (3.761)

2020 SCI-E First-iGAP: A Randomized Placebo-Controlled Phase II Study of First-line Intercalated Gefitinib and Pemetrexed-Cisplatin Chemotherapy for Never-Smoker Lung Adenocarcinoma Patients: CLINICAL LUNG CANCER. S1525-7304(20):30143~1 (3.55)

2020 SCI-E A Determination Scheme for Quasi-Identifiers Using Uniqueness and Influence for De-Identification of Clinical Data: JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS. 10(2):295~303 (0.659)

2019 SCI-E Fatal Simultaneous Multi-organ Failure Following Pembrolizumab Treatment for Refractory Thymoma: Clinical Lung Cancer. 19:30282~30287 (4.117)

2019 SCI The clinical impact of family history of cancer in female never-smoker lung adenocarcinoma: LUNG CANCER. 136:15~22 (4.599)

2019 SCI-E Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for Re-biopsy in Previously Treated Lung Cancer: CANCER RESEARCH AND TREATMENT. 51(4):1488~1499 (3.363)

2018 SCI EGFR and HER3 signaling blockade in invasive mucinous lung adnocarcinoma harboring an NRG1 fusion: Lung cancer. 124:71~75 (4.486)

2018 SCI Association of PD-L1 Expression with Tumor-Infiltrating Immune Cells and Mutation Burden in High-Grade Neuroendocrine Carcinoma of the Lung: Journal of thoracic oncology. 13(5):636~648 (10.34)

2017 SCI-E Incorporating Erlotinib or Irinotecan Plus Cisplatin into Chemoradiotherapy for Stage III Non-small Cell Lung Cancer According to EGFR Mutation Status: Cancer Research and Treatment. 49(4):981~989 (3.772)

2017 SCI-E Randomized phase II study of afatinib plus simvastatin versus afatinib alone in previously treated patients with advanced nonadenocarcinomatous Non-small Cell Lung Cancer: Cancer Research and Treatment. 49(4):1001~1011 (3.772)

2017 SCI-E Case of sclerosing pneumocytoma combined with a typical carcinoid and pulmonary adenocarcinoma in different lobes: Thoracic Cancer. 8(4):372~375 (1.116)

2017 기타 Molecular Testing of Lung Cancers: Journal of Pathology and Translational Medicine. 51:242~254 (1.06)

2016 SCI Integrated genomic analysis of recurrence-associated small non-coding RNAs in oesophageal cancer: Gut. 66(2):215~225 (14.921)

2016 SCI-E Prognostic significance of venous invasion and maximum standardized uptake value of 18F-FDG PET/CT in surgically resected T1N0 esophageal squamous cell carcinoma: European Journal of Surgical Oncology. 43(2):471~477 (2.94)

2016 SCI-E A Phase II Study of Poziotinib in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma who Have Acquired Resistance to EGFR-Tyrosine Kinase Inhibitors.: Cancer Research and Treatment. 49(1):10~19 (4.245)

2016 SCI Prognostic Differences in Subgroups of Patients With Surgically Resected T3 Non-Small Cell Lung Cancer.: Annals of Thoracic Surgery. 102(5):1630~1637 (3.021)

2016 SCI-E Oncogenic function and clinical implications of SLC3A2-NRG1 fusion in invasive mucinous adenocarcinoma of the lung: Oncotarget. 7(43):69450~69465 (5.008)

2016 SCI-E ERCC1 expression-based randomized phase II study of gemcitabine/cisplatin versus irinotecan/cisplatin in patients with advanced non-small cell lung cancer: Cancer Res Treat. Online:Published (4.245)

2016 SCI-E MassARRAY, pyrosequencing, and PNA clamping for EGFR mutation detection in lung cancer tissue and cytological samples: a multicenter study: J Cancer Res Clin Oncol. 142(2):2209~2216 (3.141)

2016 SCI-E Comparison of Epidermal Growth Factor Receptor Mutations between Metastatic Lymph Node Diagnosed by EBUS-TBNA and Primary Tumor in Non-Small Cell Lung Cancer: PLOS ONE. 11(9):e0163652~e0163652 (3.057)

2016 SCI-E PNA clamping-assited fluorescence melting curve analysis for detecting EGFR and KRAS mutations in the circulating tumor DNA of patients with advanced NSCLC: BMC Cancer. 16:627 ~627 (3.265)

2016 기타 Association between the CpG island methylator phenotype and its prognostic significance in primary pulmonary adenocarcinoma: Tumor Biol. 37:10675~10684 (2.926)

2016 SCI-E Prostate Stem Cell Antigen Expression in Radical Prostatectomy Specimens Predicts Early Biochemical Recurrence in Patients with High Risk Prostate Cancer Receiving Neoadjuvant Hormonal Therapy: PloS one. 11(3):e0151646~e0151646 (3.057)

2016 SCI-E Comparison of EGFR mutation detection between the tissue and cytology using direct sequencing, pyrosequencing and peptide nucleic acid clamping in lung adenocarcinoma: Korean multicentre study: QJM: An International Journal of Medicine. 109:167~173 (3.131)

2015 SCI Overexpression of BRCA1 or BRCA2 in prostatectomy specimens is predictive of biochemical recurrence after radical prostatectomy: Histopathology. 68(5):673~679 (3.453)

2015 기타 Analysis of Mutations in Epidermal Growth Factor Receptor Gene in Korean Patients with Non-small Cell Lung Cancer: Summary of a Nationwide Survey: Journal of Pathology and Translational Medicine. 49:481~488 ()

2015 SCI-E Therapeutic effect of anti CEACAM6 monoclonal antibody against lung adenocarcinoma by enhancing anoikis sensitivity: Biomaterials. 67:32~41 (8.402)

2015 SCI-E Complex renal cysts associated with crizotinib treatment: Cancer medicine [electronic resource]. 4(6):887~896 (2.5)

2015 SCI A nomogram to predict brain metastasis as the first relapse in curatively resected non-small cell lung cancer patients: Lung cancer. 88(2):201~207 (3.958)

2015 SCI-E Overexpression of ERG and wild-type PTEN are associated with favorable clinical prognosis and low biochemical recurrence in prostate cancer: PloS one [electronic resource]. 10(4):0122498~0122498 (3.234)

2015 SCI EGFR mutation testing practices within the Asia Pacific region: Results of a multicenter diagnostic survey.: Journal of thoracic oncology. 10(3):438~445 (5.282)

2015 SCI Phase I/II study of gefitinib (Iressa(?)) and vorinostat (IVORI) in previously treated patients with advanced non-small cell lung cancer: Cancer chemotherapy and pharmacology. 75(3):475~483 (2.769)

2015 SCI-E Clinical Likelihood of Sporadic Primary EGFR T790M Mutation in EGFR-Mutant Lung Cancer: Clinical Lung Cancer. 16(1):46~50 (3.104)

2014 SCI-E Whole-genome analysis of a patient with early-stage small-cell lung cancer: The pharmacogenomics journal. 14(6):503~508 (5.513)

2014 SCI Comparison of targeted next-generation sequencing with conventional sequencing for predicting the responsiveness to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy in never-smokers with lung adenocarcinoma: Lung cancer. 85(2):161~167 (3.737)

2014 SCI Clinical outcome according to the level of preexisting epidermal growth factor receptor T790M mutation in patients with lung cancer harboring sensitive epidermal growth factor receptor mutations.: Cancer. 120(14):2090~2098 (4.901)

2014 SCI Genetic variations associated with postoperative recurrence in stage I non-small-cell lung cancer: Clinical Cancer Research. 20(12):3272~3279 (8.193)

2014 SCI-E Epigenetic silencing of the non-coding RNA nc886 provokes oncogenes during human esophageal tumorigenesis: Oncotarget. 5(11):3472~3481 (6.627)

2014 SCI miR-592 and miR-552 Can Distinguish Between Primary Lung Adenocarcinoma and Colorectal Cancer Metastases in the Lung: Anticancer research. 34(5):2297~2302 (1.872)

2014 SCI Genomic profile analysis of diffuse-type gastric cancers: Genome Biology. 15(4):R55~R55 (10.465)

2014 기타 Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group.: Korean journal of pathology. 48(1):1~9 (0)

2013 SCI EBUS-centred versus EUS-centred mediastinal staging in lung cancer: a randomised controlled trial: Thorax. 69(3):261~268 (8.562)

2013 SCI-E Clinical significance of heterogeneity in response to retreatment with epidermal growth factor receptor tyrosine kinase inhibitors in patients with lung cancer acquiring secondary resistance to the drug: Cinical lung cancer. 15(2):145~151 (3.22)

2013 SCI Post-progression survival in patients with non-small cell lung cancer with clinically acquired resistance to gefitinib: Journal of Korean medical science. 28(11):1595~1602 (1.249)

2013 SCI Impact of EGFR tyrosine kinase inhibitors versus chemotherapy on the development of leptomeningeal metastasis in never smokers with advanced adenocarcinoma of the lung.: Journal of neurooncology. 115(1):95~101 (3.115)

2013 SCI-E Effects of upconversion nanoparticles on polymerase chain reaction.: PLoS One. 8(9):e73408~e73408 (3.73)

2013 SCI-E Pathway-Based Analysis Using Genome-wide Association Data from a Korean Non-Small Cell Lung Cancer Study: PLoS One. 8(6):e65396~e65396 (3.73)

2013 기타 MALDI MS Profiles Distinguish ER-Negative Breast Cancers from Lung Adenocarcinoma: Journal of Proteomics and Bioinformatics. 2013:S6~S6 (0)

2013 SCI-E Guideline Recommendations for EGFR Mutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group.: Korean J Pathol. 47:100~106 (0.174)

2012 SCI Lipid MALDI profile classifies non-small cell lung cancers according to the histologic type: Lung cancer. 76(2):197~203 (3.434)

2012 기타 A Case of Capecitabine-Induced Sarcoidosis: Tuberculosis and Respiratory Diseases. 72(3):318~322 (0)

2012 SCI-E Anti-adhesive functions of CD43 expressed on colon carcinoma cells through the modulation of integrins.: Experimental and Molecular Pathology. 92(1):82~89 (2.425)

2012 SCI Matrix-assisted laser desorption/ionization mass spectrometry reveals decreased calcylcin expression in small cell lung cancer: Pathology International. 62(1):28~35 (1.624)

2011 SCI Human papillomavirus in oropharyngeal squamous cell carcinomas in korea: Use of G1 cycle markers as new prognosticators.: Head & Neck. Online:Published (2.182)

2011 SCI Comparison of clinical outcome of patients with non-small-cell lung cancer harbouring epidermal growth factor receptor exon 19 or exon 21 mutations.: Journal of clinical pathology. 64(11):947~952 (2.475)

2011 SCI Circulating cell-free DNA in plasma of never smokers with advanced lung adenocarcinoma receiving gefitinib or standard chemotherapy as first-line therapy.: Clin Cancer Res. 17(16):5179~87 (7.338)

2011 SCI DNA repair gene polymorphisms and benefit from gefitinib in never-smokers with lung adenocarcinoma: Cancer. 117(14):3201~3208 (5.131)

2011 SCI Tumor Necrosis as a Prognostic Factor for Stage IA Non-Small Cell Lung Cancer: Annals of Thoracic Surgery. 91:1668~1673 (3.792)

2011 SCI Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas: Oncogene. 30(21):2433~2442 (7.414)

2010 SCI A Genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population: Human Molecular Genetics. 19(24):4948~4954 (7.386)

2010 SCI Transbronchial and Transesophageal Fine Needle Aspiration Using an Ultrasound Bronchoscope in Mediastinal Staging of Potentially Operable Lung Cancer.: Chest. 138(4)::795~802 (6.36)

2010 SCI Prognostic value of single nodal zone metastasis in non-small-cell lung cancer.: European journal of cardio-thoracic surgery. 38(4):491~497 (2.397)

2010 SCI Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lung cancer.: Lung Cancer. 70(1):51-6:51~56 (3.14)

2010 SCI Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations: Nature Genetics. 42:893~896 (34.284)

2010 SCI Prognostic value of single nodal zone metastasis in non-small-cell lung cancer.: European Journal of Cardio-thoracic Surgery.. 38(4):491~497 (2.397)

2010 SCI-E Association of SUMO-1 and UBC9 genotypes with tumor response in non-small cell lung cancer treated with irinotecan-based chemotherapy: The Pharmacogenomics Journal. 10(2):86~93 (4.398)

2010 SCI-E First-Line Gefitinib Treatment for Patients with Advanced Non-small Cell Lung Cancer with Poor Performance Status.: J Thorac Oncol.. 5(3):361~368 (4.547)

2010 SCI-E Desmoplastic fibroma with malignant transformation.: Annals of diagnostic pathology. 14(1):50~55 (1.128)

2009 SCI-E Transoesophageal needle aspiration using a convex probe ultrasonic bronchoscope: Respirology. 14(6):843~849 (1.849)

2009 SCI Vaccination with recombinant adenoviruses and dendritic cells expressing prostate-specific antigens is effective in eliciting CTL and suppresses tumor growth in the experimental prostate cancer.: Prostate. 69(9):938~948 (3.069)

2009 SCI Application of endobronchial ultrasound-guided transbronchial needle aspiration following integrated PET/CT in mediastinal staging of potentially operable non-small cell lung cancer: Chest. 135(5):1280~7 (5.154)

2009 SCI-E Human immunodeficiency virus-negative plasmablastic lymphoma in Korea: Leukemia and Lymphoma. 50(4):582~587 (1.939)

2009 기타 Gastric Metastasis of Primary Lung Adenocarcinoma Mistaken for Primary Gastric Cancer: 결핵 및 호흡기학회지. 66:52~57 ()

2009 SCI Metastasis within the stomach from esophageal cancer after surgery: computed tomography findings in 6 patients.: J Comput Assist Tomogr. 33(1):113~118 (1.448)

2008 SCI-E Identification of immunohistochemical factors that predict the synchronous or metachronous development of bladder tumors in patients with upper urinary tract tumors: Urologia Internationalis. 81:306~311 (0.82)

2008 SCI Association of p53 codon 72 polymorphism and MDM2 SNP309 with clinical outcome of advanced non-small cell lung cancer: Cancer. 113:799~807 (4.632)

2008 SCI Adenocarcinoma of lung in never smoked children.: Lung Cancer. 61:266~269 (3.455)

2008 SCI Real-time endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal staging of non-small cell lung cancer: how many aspirations per target lymph node station?: Chest. 134:368~374 (4.143)

2007 SCI-E Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) of the small bowel: a rare cause of intestinal obstruction: International Journal of Colorectal Disease. 22:1137~1138 (2.006)

2007 SCI Epidermal growth factor receptor status in anaplastic thyroid carcinoma: Journal of Clinical Pathology. 60:881~884 (2.245)

2006 기타 Pathologic features of Korean prostate adenocarcinoma: Mapping analysis of 83 cases: The Korean Journal of Pathology. 40:204~209 ()

2006 SCI Detection of BRAFV600E mutation on fine-needle aspiration specimens of thyroid nodule refines cyto-pathology diagnosis, especially in BRAFV600E mutation-prevalent area: CLINICAL ENDOCRINOLOGY. 65:660~666 (3.412)

2006 SCI Epstein-Barr virus and human immunodeficiency virus-negative oral plasmablasticlymphoma.: J Oral Pathol Med. 35:382~384 (1.53)

2005 SCI Successful treatment of Epstein-Barr virus-associated hemophagocyticlymphohistiocytosis with HLH-94 protocol: J Korean Med Sci. 20:209~214 (0.65)

2005 SCI Expression of caveolin-1 in pleomorphic carcinoma of the lung is correlatedwith a poor prognosis: Anticancer Res. 25:4631~4637 (1.604)

2004 기타 Functional and phenotypic characterization of cord blood-derived dendritic cells: The Korean Journal of Pediatric Hematology-Oncology. 11:217~227 ()

2004 기타 Entry of lymphocytes into the brain and expression of ICAM-1 on the brain endothelium: The Korean Journal of Anatomy. 37:431~439 ()

2003 SCI Myeloid sarcoma of both kidneys, the brain, and multiple bones in a nonleukemicchild.: Yonsei Med J. 44:740~743 (0.628)

2002 SCI Main pulmonary artery stenosis caused by fibrocalcified mass in a young infant.: J Korean Med Sci. 17:560~563 (0.65)

2002 SCI Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy.: J Reprod Immunol. 57:143~150 (2.22)

2002 SCI Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division: Immunology. 107:452~460 (3.507)

2000 SCI LFA-1- and ICAM-1-dependent homotypic aggregation of human thymocytes inducedby JL1 engagement.: Mol Cells. 9:662~667 (1.677)

2000 SCI Up-regulation and co-expression of fibroblast growth factor receptors in humangastric cancer.: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 126:519~528 (2.503)