교수진 소개
- Name
- Lee, Chanju
- Faculty Appointment
(title, department)
-
Assistant Professor, Department of Cancer Biomedical Science, National Cancer Center-Graduate School of Science and Policy
- Area of Expertise
- Tumor immunology, Immunotherapy
- Contact no
- +82-31-920-2549
- E-mail
- 76407@ncc.re.kr
- Work Experience
-
Research Scientist, Department of Cancer Biomedical Science, National Cancer Center-Graduate School of Science and Policy, Goyang, Korea (2021-present)
Post-Doc. Fellow, Cancer Immunology Branch, National Cancer Center, Goyang, Korea (2019-2021)
Research Intern, Department of Applied chemistry, Biochemistry lab, Dongduk Women’s University, Seoul, Korea (2012-2014)
- Educational Background
-
Ph.D., Science in Korean Medicine, Kyung Hee University, Seoul, Korea (2019)
M.S., Cancer Preventive Material Development, Kyung Hee University, Seoul, Korea (2016)
B.S., Applied Chemistry, Dongduk Women’s University, Seoul, Korea (2014)
- Research Interests
-
Dr. Lee is interested in fundamentally understanding the feature of tumor-associated immune cells which contribute to tumor microenvironment. Her research aims to modulate the immune system for overcoming the anti-cancer resistance and enhancing response to immunotherapies.
- Achievements
-
1. Lee, C., et al., Combination of anti-PD-L1 antibody with peptide MEL-dKLA targeting M2 tumor-associated macrophages suppresses breast cancer metastasis. Cancer Communications, 2022.
2. Lee, C., et al., TAMpepK Suppresses Metastasis through the Elimination of M2-Like Tumor-Associated Macrophages in Triple-Negative Breast Cancer. International Journal of Molecular Sciences, 2022. 23(4).
3. Jeon, I.S., et al., Anticancer nanocage platforms for combined immunotherapy designed to harness immune checkpoints and deliver anticancer drugs. Biomaterials, 2021. 270: p. 120685.
4. Jeong, H., et al., Targeting of adipose tissue macrophages by bee venom phospholipase A2 attenuates high-fat diet-induced obesity. International Journal of Obesity, 2021. 45(8): p. 1656-1667.
5. Lee, C., et al., Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation. Frontiers in Immunology, 2020. 11: p. 77.
6. Lee, C., et al., Evaluation of the Efficacy and Safety of the Herbal Formula PM014 in a Cisplatin- and Paclitaxel-Treated Tumor-Bearing Mouse Model. Integrative Cancer Therapies, 2020. 19: p. 1534735420924711.
7. Lee, C., et al., Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide. Journal for ImmunoTherapy of Cancer, 2019. 7(1): p. 147.
8. Lim, D., et al., Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung. Frontiers in Physiology, 2018. 9: p. 47.
9. Lee, G., et al., Cigarette Smoking Triggers Colitis by IFN-gamma(+) CD4(+) T Cells. Front Immunol, 2017. 8: p. 1344.
10. Lee, C., et al., Melittin suppresses tumor progression by regulating tumor-associated macrophages in a Lewis lung carcinoma mouse model. Oncotarget, 2017. 8(33): p. 54951-54965.
11. Ye, M., et al., Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer's disease. Journal of Neuroinflammation, 2016. 13: p. 10.
12. Ye, M., et al., Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson's disease alpha-synuclein transgenic mice. Experimental and Molecular Medicine, 2016. 48(7): p. e244.
13. Kim, H., et al., Immunotherapy with methyl gallate, an inhibitor of Treg cell migration, enhances the anti-cancer effect of cisplatin therapy. Korean Journal of Physiology & Pharmacology, 2016. 20(3): p. 261-8.
14. Baek, H., et al., Neuroprotective effects of CD4+CD25+Foxp3+ regulatory T cells in a 3xTg-AD Alzheimer's disease model. Oncotarget, 2016. 7(43): p. 69347-69357.
15. Chung, E.S., et al., Bee Venom Phospholipase A2, a Novel Foxp3+ Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating Neuroinflammatory Responses in a Mouse Model of Parkinson's Disease. Journal of Immunology, 2015. 195(10): p. 4853-60.
