교수진 소개
- Name
- Yun Hee KIM, Ph.D.(adjunct professor)
- Faculty Appointment
(title, department)
- Professor, Department of Cancer Biomedical Science, NCC-GCSP Senior Scientist, Molecular Imaging & Therapy Branch, Division of Convergence Technology, Research Institute of National Cancer Center
- Area of Expertise
- Oncology & Cancer Gene Therapy
- E-mail
- sensia37@ncc.re.kr
- Work Experience
- 2006.03-2007.03 Postdoctoral Fellow, POSTECH
2007.04- present National Cancer Center
- Educational Background
- 1994 Kyunghee University; Biology; B.S.
1996 Yonsei University; Biochemistry; M.S.
2006 Pohang University of Science and Technology (POSTECH) ; Biotechnology; Ph.D.
- Research Interests (Please place in paragraph form)
- Her current research interests include development of multifunctional cancer theranostics using Aptamer, application of molecular imaging in cancer gene therapy, and investigation of molecular mechanism of pancreatic cancer metastasis.
- International Collaboration
-
- Achievements
-
2022 SCI-E Oncogenic fusion of BCAR4 activates EGFR signaling and is sensitive to dual inhibition of EGFR/HER2: FRONTIERS IN MOLECULAR BIOSCIENCES. 9:952651~ (6.113)
2022 SCI-E An internalizing antibody targeting of cell surface GRP94 effectively suppresses tumor angiogenesis of colorectal cancer: BIOMEDICINE & PHARMACOTHERAPY. 150:113051~ (7.419)
2022 SCI-E Targeted next generation sequencing of circulating tumor DNA provides prognostic information for management in breast cancer patients: ANNALS OF TRANSLATIONAL MEDICINE. 10(2):28~ (3.616)
2022 SCI-E Establishment of Patient-derived Preclinical Models for Invasive Papillary Cholangiocarcinoma: ANTICANCER RESEARCH. 42(1):599~608 (2.48)
2021 SCI-E Flashlight into the Function of Unannotated C11orf52 using Affinity Purification Mass Spectrometry: JOURNAL OF PROTEOME RESEARCH. 20(12):5340~5346 (4.466)
2021 SCI-E Genomic Instability of Circulating Tumor DNA as a Prognostic Marker for Pancreatic Cancer Survival: A Prospective Cohort Study: CANCERS. 13(21):5466~ (6.639)
2021 SCI-E A fusion of CD63?BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis: BRITISH JOURNAL OF CANCER. 124(1):290~290 (5.791)
2020 SCI-E Bioinformatic Prediction of Gene Ontology Terms of Uncharacterized Proteins from Chromosome 11: JOURNAL OF PROTEOME RESEARCH. 19(12):4907~4912 (4.074)
2020 SCI-E Therapeutic Application of Drug-Conjugated HER2 Oligobody (HER2-DOligobody): INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 21(9):E3286~ (4.556)
2019 SCI A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells: cell metabolism. Online:Published (22.415)
2019 SCI FeSe quantum dots for in vivo multiphoton biomedical imaging: SCIENCE ADVANCES. (5)12:eaay0044~eaay0044 (12.804)
2019 SCI Comprehensive Profiling of Surface Gangliosides Extracted from Various Cell Lines by LC-MS/MS: Cells. 8(11):E1323~E1323 (5.656)
2019 SCI-E Development of Patient-Derived Preclinical Platform for Metastatic Pancreatic Cancer: PDOX and a Subsequent Organoid Model System Using Percutaneous Biopsy Samples: Frontiers in oncology. 9:875~ (4.137)
2019 SCI-E EI24, as a Component of Autophagy, Is Involved in Pancreatic Cell Proliferation: Frontiers in Oncology. Online:Published (4.137)
2019 SCI-E Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment: GUT AND LIVER. 13(6):683~689 (2.968)
2019 SCI-E Integrative In Vivo Drug Testing Using Gene Expression Signature and Patient-Derived Xenografts from Treatment-Refractory HER2 Positive and Triple-Negative Subtypes of Breast Cancer: CANCERS. 11(4):E574~E574 (6.162)
2018 기타 Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer: GENOMICS & INFORMATICS. 16(4):e35~e35 (0)
2018 SCI Prognostic implications of multiplex detection of KRAS mutations in cell-free DNA from patients with pancreatic ductal adenocarcinoma: Clinical chemistry. 64(4):726~734 (8.636)
2017 SCI Inhibition of BMP signaling overcomes acquired resistance to cetuximab in oral squamous cell carcinomas: Cancer Letters. 414:181~189 (6.375)
2017 SCI-E DCK expression, a potential predictive biomarker in the adjuvant gemcitabine chemotherapy for biliary tract cancer after surgical resection: results from a phase II study: oncotarget. 8(46):81394~81404 (5.168)
2017 SCI-E Induction Chemotherapy with Gemcitabine and Cisplatin Followed by Simultaneous Integrated Boost-Intensity Modulated Radiotherapy with Concurrent Gemcitabine for Locally Advanced Unresectable Pancreatic Cancer: Results from a Feasibility Study: Cancer Research and Treatment. 49(4):1022~1032 (3.772)
2017 SCI Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation.: Experimental & Molecular Medicine. 49(7):e351~e351 (5.063)
2017 SCI Preclinical development of a humanized neutralizing antibody targeting HGF: Experimental & Molecular Medicine. 49(3):e309~e309 (5.063)
2017 SCI-E Tracking Perfluorocarbon Nanoemulsion Delivery by 19F MRI for Precise High Intensity Focused Ultrasound Tumor Ablation: Theranostics. 7(3):562~572 (8.712)
2017 SCI The Effectiveness of Ferritin as a Contrast Agent for Cell Tracking MRI in Mouse Cancer Models: Yonsei Medical Journal. 58(1):51~58 (1.537)
2016 SCI-E C-terminally mutated tubby protein accumulates in aggresomes.: BMB reports. 50(1):37~42 (2.782)
2016 SCI-E Efficacy of pancreatic exocrine replacement therapy for patients with unresectable pancreatic cancer in a randomized trial: Pancreatology. 16(6):1099~1105 (2.406)
2016 SCI An aptamer-antibody complex (oligobody) as a novel delivery platform for targeted cancer therapies: Journal of Controlled Release. 229:1~9 (7.441)
2016 SCI-E DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression: Oncotarget. 7(14):17699~17710 (5.008)
2016 SCI-E Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma: Theranostics. 6:357~368 (8.854)
2014 SCI Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model: Cancer Letters. 344(2):223~231 (5.016)
2014 SCI Bispecific Her2Χ cotinine antibody in combination with cotinine-(histidine) 2-iodine for the pre-targeting of Her2-positive breast cancer xenografts.: Journal of cancer research and clinical oncology. 140(2):227~233 (3.009)
2014 SCI Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8: Biomaterials. 35(1):578~589 (8.312)
2013 SCI Comparative Secretome Analysis of Human Bone Marrow-Derived Mesenchymal Stem Cells During Osteogenesis: journal of cellular physiology. 228(1):216~224 (4.218)
2012 SCI An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human bone marrow-derived mesenchymal stem cells: journal of cellular physiology. 228(3):617~626 (4.218)
2012 SCI DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling: Nature Communications. 3:1296~1296 (7.396)
2012 SCI Wedelolactone Inhibits Adipogenesis Through the ERK Pathway in Human Adipose Tissue-Derived Mesenchymal Stem Cells: journal of cellular biochemistry. 113(11):3436~3445 (2.868)
2012 SCI Over-expression of miR-145 Enhances the Effectiveness of HSVtk gene Therapy for Malignant Glioma: Cancer Letters. 320(1):72~80 (4.238)
2012 SCI Hypoxia-induced up-regulation of apelin is associated with a poor prognosis in oral squamous cell carcinoma patients: Oral Oncology. 48(6):500~506 (2.857)
2012 기타 Apoptosis of human islet cells by cytokines.: Immune network.. 12(3):113~117 (0)
2011 SCI An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells.: Cancer letters.. 313(1):76~83 (4.864)
2011 SCI A highly sensitive magnetite nanoparticle as a simple and rapid stem cell labelling agent for MRI tracking: Journal of Materials Chemistry. 21:7742~7747 (5.101)
2011 SCI Ochratoxin A inhibits adipogenesis through the ERK-1 PPAR-γ pathway in human adipose tissue-derived mesenchymal stem cells: Stem cells and Development. 20(3):415~426 (4.791)
2010 SCI Subtype-specific role of phospholipase C-β in bradykinin and LPA signaling through differential binding of different PDZ scaffold proteins: Cellular Signalling. 22:1153~1161 (4.094)
2009 SCI-E Sphingosine 1-phosphate induces vesicular endothelial growth factor expression in endothelial cells: BMB reports. 42:685~690 ()
2009 SCI Galectin-3 stabilizes heterogeneous nuclear ribonucleoprotein Q to maintain proliferation of human colon cancer cells: Cellular and Molecular Life Sciences. 66:350~364 (5.511)
2008 SCI Hydrogen Peroxide-Induced VCAM-1 Expression in Pancreatic Islets and beta-Cells Through Extracellular Ca2+ Influx.: Transplantation. 86:1257~1266 (3.641)
2008 SCI Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCβ2 axis: blood. Online:Published (10.896)
2008 SCI Potential inhibition of PDK1/Akt signaling by phenothiazines suppresses cancer cell proliferation and survival: Ann N Y Acad Sci. 1138:393~403 (1.731)
2008 SCI A myristoylated pseudosubstrate peptide of PKC-zeta induces degranulation in HMC-1 cells independently of PKC-zeta activity.: Life Sciences. 82:733~740 (2.257)
2008 SCI Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis.: Chemico-Biological Interaction. 171:57~66 (3.09)
2007 SCI Molecular imaging of endogenous mRNA expression in a mouse tumor model by adenovirus harboring trans-splicing ribozyme: FEBS Letters. 28:5396~5400 (3.263)
2007 SCI O-GlcNAc modification modulates the expression of osteocalcin via OSE2 and Runx2: Biochemical and biophysical research communications. 362:325~329 (2.855)
2007 SCI Inhibition of phospholipase C-beta1-mediated signaling by O-GlcNAc modification: J. Cell. Physiol.. 207:689~696 (4.362)
2006 SCI RGS2 promotes formation of neurites by stimulating microtubule polymerization: Cell signal.. 18:2182~2192 (4.4)
2006 SCI Novel compound, CH-223191, prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.: Mol Pharmacol.. 69:1871~1878 (4.612)
2005 SCI 2,2',4,6,6'-Pentachlorobiphenyl-induced apoptosis is limited by cyclooxygenase-2 induction.: Toxicol Sci.. 83:397~404 (3.06)
2005 SCI G2 arrest and apoptosis by 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS), a novel cytotoxic compound.: Biochem Pharmacol.. 69:1333~1341 (3.6)
2004 SCI NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation.: Mol Cell Biol.. 24:5069~5079 (6.09)
