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교수진

교수진 소개

Kyung-Hee KIM

Name
Kyung-Hee KIM, Ph.D.
Faculty Appointment
(title, department)
Assistant Professor, Biochemistry/Proteomics/Mass Spectrometry
Area of Expertise
Biochemistry / Proteomics / Mass Spectrometry
E-mail
kyunghee@ncc.re.kr
Work Experience
Team Leader, Proteomics Core Facility, National Cancer Center (2019~Present)
Research Scientist, Omics Core Laboratory, National Cancer Center (2014~2019)
Research Scientist, Colorectal Cancer Branch, National Cancer Center (2007~2017)
Educational Background
Ph.D. Cancer Biology, Seoul National University, Korea (2008-2013)
M.S. Molecular Oncology, Seoul National University, Korea (2004-2007)
B.S. Biology, Yonsei University, Korea (2000-2004)
Research Interests
Dr. Kim’s research interests are to understand of cellular and molecular mechanisms of biomarker candidates and to find cancer biomarkers from patient’s derived tissue, blood, urine and various body fluids using high resolution mass spectrometers.
International Collaboration
Member, The Human Proteome Organization
Member, The Korean Human Proteome Organization
Member, American Society for Mass Spectrometry
Member, Korean Society for Mass Spectometry
Achievements
2018 SCI Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition: Cancers. 10(11):455~455 (5.326)

2018 SCI Allosteric inhibition site of transglutaminase 2 is unveiled in the N terminus: Amino acids. 50(11):1583~1594 (2.906)

2018 SCI-E Individualized metabolic profiling stratifies pancreatic and biliary tract cancer: a useful tool for innovative screening programs and predictive strategies in healthcare: EPMA Journal. 9(3):287~297 (3.9)

2018 SCI Deleted in malignant brain tumor 1 is a novel prognostic marker in colorectal cancer: Oncology reports. 39(5):2279~2287 (2.976)

2017 SCI Clinical multi-omics strategies for the effective cancer management: Journal of Proteomics. 188:97~106 (3.914)

2017 SCI-E Profiling of Serum Metabolites Using MALDI-TOF and Triple-TOF Mass Spectrometry to Develop a Screen for Ovarian Cancer.: Cancer Research and Treatment. 50(3):883~893 (3.772)

2017 SCI-E Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action: Oncotarget. 9(5):5979~5992 (5.168)

2017 SCI-E Cerebrospinal fluid metabolomic profiles can discriminate patients with leptomeningeal carcinomatosis from patients at high risk for leptomeningeal metastasis: Oncotarget. 8(60):101203~101214 (5.168)

2017 SCI-E Reduced levels of N’-methyl-2-pyridone-5-carboxamide and lysophosphatidylcholine 16:0 in the serum of patients with intrahepatic cholangiocarcinoma, and the correlation with recurrence-free survival: Oncotarget. 8(68):112598~112609 (5.168) 2017 SCI Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents: Amino Acids. 49(9):1469~1485 (3.173)

2017 SCI SET domain-containing protein 5 is required for expression of primordial germ cell specification-associated genes in murine embryonic stem cells: Cell Biochemistry and Function. 35(5):247~253 (2.186)

2017 SCI-E C1QBP is upregulated in colon cancer and binds to apolipoprotein A-I: Experimental and Therapeutic Medicine. 13(5):2493~2500 (1.261)

2017 SCI Inter molecular crosslinking activity is engendered by the dimeric form of transglutaminase 2: Amino Acids. 49(3):461~471 (3.196)

2017 SCI-E Identification of calgranulin B interacting proteins and network analysis in gastrointestinal cancer cells: PLoS One. 12(2):e0171232~e0171232 (2.806)

2017 SCI-E Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116: Oncotarget. 8(4):6819~6823 (5.008)

2016 SCI-E Low-mass-ion discriminant equation (LOME) for ovarian cancer screening: BioData Mining. 9:32~32 (1.64)

2016 SCI Seven low-mass ions in pretreatment serum as potential predictive markers of the chemoradiotherapy response of rectal cancer: Anti cancer Drugs. 27:787~793 (2.268)

2016 SCI Investigation of early and advanced stages in ovarian cancer using human plasma by differential scanning calorimetry and mass spectrometry: Archives of Pharmacal Research. 39:668~676 (2.49)

2016 SCI-E Antitumor effects of calgranulin B internalized in human colon cancer cells: Oncotarget. 7(15):20368~20380 (5.008)

2016 SCI Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid: Mediators of Inflammation. 2016:1903849~1903849 (3.418)

2015 SCI-E Reduced expression of HSP27 following HAD-B treatment is associated with Her2 downregulation in NIH:OVCAR-3 human ovarian cancer cells.: Molecular medicine reports. 12(3):3787~3794 (1.554)

2014 SCI-E Differential levels of L-homocysteic acid and lysophosphatidylcholine (16:0) in sera of patients with ovarian cancer: Oncology letters. 8(2):566~574 (0.987)

2014 SCI Low-mass-ion discriminant equation: A new concept for colorectal cancer screening.: International Journal of Cancer. 134(8):1844~1853 (5.007)

2014 SCI Serpin B5 is a CEA-interacting biomarker for colorectal cancer.: International Journal of Cancer. 134(7):1595~1604 (5.007)

2014 SCI-E Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells: BMC Cancer. 14:160~160 (3.319)

2014 SCI Decreased Cellular Levels of Palmitic Amide are Linked to 5-fluorouracil Resistance in Human Colon Cancer Cells: Hepato-gastroenterology. 61(130):343~348 (0.907)

2014 SCI CD133 and CD133-regulated nucleophosmin linked to 5-fluorouracil susceptibility in human colon cancer cell line SW620: Electrophoresis. 35(4):522~532 (3.161)

2013 SCI Establishment and characterization of seven human breast cancer cell lines including two triple-negative cell lines: International Journal of Oncology. 43(6):2073~2081 (2.657)

2013 SCI Adenosine dialdehyde suppresses MMP-9-mediated invasion of cancer cells by blocking the Ras/Raf-1/ERK/AP-1 signaling pathway: Biochemical Pharmacology. 86(9):1285~1300 (4.576)

2013 SCI-E Dipeptidyl peptidase 10, a novel prognostic marker in colorectal cancer: Yonsei Medical Journal. 54(6):1362~1369 (1.306)

2013 SCI Transglutaminase2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma: The FASEB Journal. 27(9):3487~3495 (5.704)

2013 SCI HangAmDan-B, an Ethnomedicinal Herbal Mixture, Suppresses Inflammatory Responses by Inhibiting Syk/NF-κB and JNK/ATF-2 Pathways: Journal of Medicinal Food. 16(1):56~65 (1.642)

2013 SCI Depletion of cathepsin D by transglutaminase2 through protein cross-linking promotes cell survival: Amino Acids. 44(1):73~80 (3.914)

2012 SCI-E Up-regulated expression of l-caldesmon associated with malignancy of colorectal cancer: BMC Cancer. 12(1):601~601 (3.011)

2012 SCI Induction of LGR5 by H2O2 treatment is associated with cell proliferation via the JNK signaling pathway in colon cancer cells.: International Journal of Oncology. 41(5):1744~1750 (2.399)

2012 SCI Hydroxymethylglutaryl-Coenzyme A Synthase 2 Expression Is Associated With Chemoradiotherapy Responses in Colorectal Cancer: Diseases of the Colon & Rectum. 55(6):686~694 (3.132)

2012 SCI Establishment and characterization of six human gastric carcinoma cell lines, including one naturally infected with Epstein-Barr virus.: Cellular Oncology. 35(2):127~136 (3.105)

2011 SCI-E Proteome alteration in human colon cancer cells by the treatment of HangAmDan-B: Biochip Journal. 5:114~122 (0.868)

2011 SCI Establishment and characterization of six human lung cancer cell lines: EGFR, p53 gene mutations and expressions of drug sensitivity genes: Cellular Oncology. 34(1):45~54 (3.175)

2010 SCI-E Promoter hypermethylation and loss of CD133 gene expression in colorectal cancers.: World Journal of Gastroenterology. 16:3153~3160 (2.092)

2010 SCI Identification of hypoxanthine as a urine marker for non-Hodgkin lymphoma by low-mass-ion profiling: BMC Cancer. 10:55~55 (2.736)

2010 SCI Establishment and Characterization of 13 Human Colorectal Carcinoma Cell Lines : Mutations of Genes and Expressions of Drug Sensitivity Genes and Cancer Stem Cell Markers.: Carcinogenesis. Online:Published (4.93)

2009 SCI Acclimation to ultraviolet irradiation affects UV-B sensitivity of Daphnia magna to several environmental toxicants.: Chemosphere. 77:1600~1608 (3.054)

2009 기타 Profiling of low mass ions in serum from colorectal cancer patients using NALDI-TOF analysis and its application for chemotherapy response prediction: IEEE NANO 2009. :559~561 ()

2009 SCI Promoter hypermethylation of the ADAM23 gene in colorectal cancer cell lines and cancer tissues: International Journal of Cancer. 124:1258~1262 (4.734)

2008 SCI Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells: Cancer Science. 99(10):1884~1891 (3.165)

2008 SCI-E Upregulated HSP27 in human breast cancer cells reduces Herceptin susceptibility by increasing Her2 protein stability: BMC Cancer. 8:286~295 (2.709)

2008 SCI Hereditary nonpolyposis colorectal cancer in endometrial cancer patients: Intenational Journal of Cancer. 122:1077~1081 (4.734)

2007 SCI Genetic alterations of the TGF-beta signaling pathway in colorectal cancer cell lines: a novel mutation in Smad3 associated with the inactivation of TGF-beta-induced transcriptional activation: Cancer Letters. 247:283~292 (3.504)

2007 SCI Establishment and characterization of cell lines from three human thyroid carcinomas: responses to all-trans-retinoic acid and mutations in the BRAF gene: Mol Cell Endocrinol. 264:118~127 (3.611)

2006 SCI Alpha-tocopheryl succinate, in contrast to alpha-tocopherol and alpha-tocopheryl acetate, inhibits prostaglandin E2 production in human lung epithelial cells: Carcinogenesis. 27:2308~2315 (4.93)

2006 SCI-E Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues: World Journal of Gastroenterology. 12:5651~5657 (2.081)
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