교수진 소개
- Name
- Hye-Ran Kim, Ph.D.
- Faculty Appointment:
(title, department)
- Research Scientist, Research Institute Branch Tumor Immunology
- Area of Expertise
- Artificial Intelligence, Deep Learning, Computer Vision, Biomedical Image Analysis
- Contact no
- 031-920-2462
- E-mail
- hrkim@ncc.re.kr
- Work Experience
- 2020.11 – 2022.9 Research Associate. School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
2019.11 – 2020.10 Staff Scientist. Department of Microbiology & Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center
2013.8 – 2019.10 Post-Doc. School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
- Educational Background
- 2009.9 – 2013.8 Ph.D. School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
2008.3 – 2009.8 M.S. School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
2003.3 – 2005.2 M.S. College of Medicine, Dong-A University
1999.3 – 2003.2 B.S. Life Science, College of Science, Dong-A University
- Research Interests
- Development
- Achievements
-
1. Jeong-Su Park, Jun-Hyeong Kim, Won-Chang Soh, Na-Young Kim, Kyung-Sik Lee, Chang-Hyun Kim, Ik-Joo Chung, Sunjae Lee, Hye-Ran Kim*, and Chang-Duk Jun*. Trogocytic molting of T cell microvilli upregulates T cell receptor surface expression and promotes clonal expansion. Nature Communications, 2023. May 14:2980.
2. Jeong-Su Park, Ik-Joo Chung, Hye-Ran Kim*, and Chang-Duk Jun*. The immunosuppressive potential of cholesterol sulfate through T cell microvilli disruption. Immune Network, 2023 Jun 15;23(3):e29.
3. Yeonsun Hong*, Brandon L. Walling*, Hye-Ran Kim, William S. Serratelli, John R. Lozada, Cooper J. Sailer, Andrea M. Amitrano, Kihong Lim, Raj Kumar Mongre, Kyun-Do Kim, Tara Capece, Elena B. Lomakina, Nicholas S. Reilly, Kevin Vo, Patrick W. Oakes, Richard E. Waugh, Chang-Duk Jun, Patrick M. Reagan, and Minsoo Kim. In vivo CRISPR screen reveals how to drive therapeutic T cell function to target tumor sites. Nature Immunology, 2023. April. 17. https://doi.org/10.1038/s41590-023-01498-x
4. Hye-Ran Kim, Jeong-Su Park, Won-Chang Soh, Na-Young Kim, Hyun-Yoong Moon, Ji-Su Lee, and Chang-Duk Jun. T cell Microvilli: Finger-shaped external structures linked to the fate of T cells. Immune Network, 2023. Feb 21;23(1):e3
5. Chang-Hyun Kim, Sang-Moo Park, Sunjae Lee, Young-Dae Kim, Se-Hwan Jang, Seon-Min Woo, Taeg-Kyu Kwon, Zee-Yong Park, Ik-Joo Chung, Hye-Ran Kim*, and Chang-Duk Jun*. NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development. Correspond. Nucleic Acid Research, 2021 Jun 4; 49(10):5760-5778
6. Hye-Ran Kim, Jeong-Su Park, Hatice Karabulut, Fatima Yasmin, and Chang-Duk Jun. Transgelin-2: a double-edged sword in immunity and cancer metastasis. Frontiers in Cell and Developmental Biology. 2021 Apr 8; 9, 606149
7. Hye-Ran Kim, Jeong-Su Park, Jin-Hwa Park, Fatima Yasmin, Chang-Hyun Kim, Se Kyu Oh, Ik-Joo Chung, and Chang-Duk Jun. Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy. Journal of Hematology & Oncology. 2021 Mar 17; 14(1):43
8. Hye-Ran Kim, Jeong-Su Park, Yasmin Fatima, Maiza Kausar, Jin-Hwa Park, and Chang-Duk Jun. Potentiating the Antitumor Activity of Cytotoxic T Cells via the Transmembrane Domain of IGSF4 That Increases TCR Avidity. Frontiers in Immunology. 2021 Feb 01; 11, 591054
9. Hye-Ran Kim and Chang-Duk Jun. T Cell Microvilli: Sensors or Senders? Frontiers in Immunology 2019 Jul 30; 10,1753
10. Hye-Ran Kim, YeVin Mun, Kyung-Sik Lee, Yoo-Jin Park, Jeong-Su Park, Jin-Hwa Park, Bu-Nam Jeon, Chang-Hyun Kim, Youngsoo Jun, Young-Min Hyun, Minsoo Kim, Sang-Myeong Lee, Chul-Seung Park, Sin-Hyeog Im, and Chang-Duk Jun. T-cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nature Communications. 2018 Sep 7; 9(1):3630
11. Bu-Nam Jeon*, Hye-Ran Kim*, Yun Shin Chung, Bo-Ra Na, Hyun-kyung Park, Chorong Hong, Yasmin Fatima, Hyeonju Oh, Chang-Hyun Kim, and Chang-Duk Jun. Actin stabilizer TAGLN2 potentiates adoptive T cell therapy by boosting the inside-out costimulation via lymphocyte function-associated antigen-1. OncoImmunology 2018 Sep 06; 7(12), e1500674
Hye-Ran Kim, Min-Sung Kwon, Sangmin Lee, YeVin Mun, Kyung-Sik Lee, Chang-Hyun Kim, Bo-Ra Na, Bit Na Rae Kim, Indre Piragyte, Hyun-Su Lee, Youngsoo Jun, Mi Sun Jin, Young-Min Hyun, Hyun Suk Jung, Ji Young Mun, and Chang-Duk Jun. TAGLN2 Polymerizes G-actin in a low ionic state but blocks Arp2/3-nucleated actin branching in physiologic conditions. Scientific Reports 2018 Apr 3; 8(1):5503
12. Hye-Ran Kim, Hyun-Su Lee, Kyung-Sik Lee, In Duk Jung, Min-Sung Kwon, Chang-Hyun Kim, Seong-Min Kim, Myung-Han Yoon, Yeong-Min Park, Sang-Myeong Lee, and Chang-Duk Jun. An Essential Role for TAGLN2 in Phagocytosis of Lipopolysaccharide-activated Macrophages. Scientific Reports 2017 Aug 18; 7(1):8731
13. Hye-Ran Kim, Bo-Ra Na, Min-Sung Kwon, You-Seong Ko, Won-Chul Han, Chang-Duk Jun. Dynamic motile T cells highly respond to the T cell stimulation via PI3K-Akt and NF-kB pathways. PLoS One 2013 Mar 26; e59793
14. Hyun-Su Lee, Young-Dae Kim, Bo-Ra Na, Hye-Ran Kim, Eun-Ju Choi, Weon Cheol Han, Hyun-Kyu Choi, Seung-Ho Lee, Chang-Duk Jun. Phytocomponent p-Hydoxycinnamic Acid Inhibits T-Cell Activation by Modulation of Protein Kinase C-q-Dependent Pathway. International Immunopharmacology 2011 Nov 17; 12(1):131-8
15. Hye-Ran Kim, Byeong-Hun Jeon, Hyun-Su Lee, Sin-Hyeog Im, Masatake Araki, Kimi Araki, Ken-ichi Yamamura, Suck-chae Choi, Do-Sim Park, and Chang-Duk Jun. IGSF4 is a novel TCR-chain-interacting protein that enhances TCR-mediated signaling. Journal of Experimental Medicine 2011 Nov 21; 208(12):2545-60
