교수진 소개
- Name
- Hyonchol JANG, Ph.D. (adjunct professor)
- Faculty Appointment
(title, department)
- Associate Professor, Department of Cancer Biomedical Science, NCC-GCSP
Senior Scientist, National Cancer Center (2013~present)
- Area of Expertise
- Cancer Stemness
- E-mail
- hjang@ncc.re.kr
- Work Experience
- Senior Scientist, National Cancer Center (2013~present)
Associate editor, Experimental & Molecular Medicine (2014~present)
Researcher, Seoul National University Medical Research Center (2012~2013)
Postdoctoral Associate/Fellow : Seoul National University College of Medicine (2006~2012)
- Educational Background
- Ph.D. (2006) Molecular & Cellular Biology, Seoul National University
M.S. (2000) Bioorganic Chemistry, Seoul National University
B.S. (1998) Chemistry, Seoul National University
- Research Interests (Please place in paragraph form)
- Dr. Jang’s research focuses on understanding “stemness” of cancer cells to elucidate cancer cells of origin and main cause of cancer relapse after standard therapy.
- International Collaboration
- Achievements
-
2022 SCI-E BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity: EXPERIMENTAL AND MOLECULAR MEDICINE. :~ (12.153)
2022 SCI-E Cholesterol Synthesis Is Important for Breast Cancer Cell Tumor Sphere Formation and Invastion: BIOMEDICINES. 10(8):1908~ (4.757)
2021 SCI-E O-GlcNAcylation of Sox2 at threonine 258 regulates the self-renewal and early cell fate of embryonic stem cells.: EXPERIMENTAL AND MOLECULAR MEDICINE. 53(11):1759~1768 (8.718)
2021 SCI-E Reply to Krupenko et al., Comment on “Lee et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer Cancers 2020, 12, 1382”: CANCERS. 13(9):2238~ (6.639)
2021 SCI-E Phospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes: EMBO REPORTS. :e51323~ (8.807)
2021 SCI-E PGC1alpha Loss Promotes Lung Cancer Metastasis through Epithelial-Mesenchymal Transition: CANCERS. 13(8):1772~ (6.639)
2021 SCI-E Overall survival of pancreatic ductal adenocarcinoma is doubled by Aldh7a1 deletion in the KPC mouse: THERANOSTICS. 11(7):3472~3488 (11.556)
2021 SCI-E FAM188B downregulation sensitized lung cancer cells to anoikis via EGFR downregulation and inhibits tumor metastasis in vivo: CANCERS. 13(2):247~ (6.639)
2020 SCI-E Oxoglutarate Carrier Inhibition Reduced Melanoma Growth and Invasion by Reducing ATP Production: PHARMACEUTICS. 12(11):1128~ (4.421)
2020 SCI-E SEZ6L2 is an important regulator of drug-resistant cells and tumor spheroid cells in lung adenocaricnoma.: BIOMEDICINES. 8(11):500~ (4.717)
2020 SCI-E A Quenched Annexin V-Fluorophore for the Real-Time Fluorescence Imaging of Apoptotic Processes In Vitro and In Vivo: ADVANCED SCIENCE. Online:Published (15.84)
2020 SCI-E Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 21(21):7878~ (4.556)
2020 SCI-E Phosphorylation of OCT4 Serine 236 Inhibits Germ Cell Tumor Growth by Inducing Differentiation: CANCERS. 12(9):E2601~ (6.126)
2020 SCI-E Targeting Oxidative Phosphorylation Reverses Drug Resistance in Cancer Cells by Blocking Autophagy Recycling: CELLS. 9(9):2013~ (4.366)
2020 SCI-E ATP Production Relies on Fatty Acid Oxidation Rather than Glycolysis in Pancreatic Ductal Adenocarcinoma: CANCERS. 12(9):2477~ (6.126)
2020 SCI-E Cancer cells undergoing epigenetic transition show short-term resistance and are transformed into cells with medium-term resistance by drug treatment: EXPERIMENTAL AND MOLECULAR MEDICINE. 52(7):1102~1115 (5.418)
2020 SCI-E Regulation of mRNA export through API5 and nuclear FGF2 interaction: NUCLEIC ACIDS RESEARCH. 48(11):6340~6352 (11.501)
2020 SCI-E The Role of Nuclear Receptor Subfamily 1 Group H Member 4 (NR1H4) in Colon Cancer Cell Survival through the Regulation of c-Myc Stability: MOLECULES AND CELLS. 43(5):459~468 (4.081)
2020 SCI-E The Combination Loss of ALDH1L1 function and phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer: CANCERS. 12(6):E1382~ (6.126)
2020 SCI-E Targeting TJP1 attenuates cell-cell aggregation and modulates chemosensitivity against doxorubicin in leiomyosarcoma: JOURNAL OF MOLECULAR MEDICINE-JMM. 98(5):761~773 (4.427)
2019 SCI-E Ascorbic acid 2-glucoside stably promotes the primitiveness of embryonic and mesenchymal stem cells through TET- and CREB1- dependent mechanisms.: Antioxidants & redox signaling. 32(1):35~59 (5.828)
2019 SCI-E Gossypol Supresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres: Biomolecules. Online:Published (4.694)
2019 SCI-E False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases: PLOS ONE. 14(9):e0222535~e0222535 (2.776)
2019 SCI-E FAK-Copy-Gain Is a Predictive Marker for Sensitivity to FAK Inhibition in Breast Cancer: CANCERS. 11(9):e1288~e1288 (6.162)
2018 SCI Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness: Experimental & molecular medicine. 50(1):137~137 (5.584)
2018 SCI-E AIMP3 depletion causes genome instability and loss of stemness in mouse embryonic stem cells: CELL DEATH AND DISEASE. 9(10):972~972 (5.638)
2018 SCI OCT4 directly regulates stemness and extracellular matrix-related genes in human germ cell tumours: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 503(3):1980~1986 (2.559)
2018 SCI Cyclin-dependent kinase 1 activity coordinates the chromatin associated state of Oct4 during cell cycle in embryonic stem cells: Nucleic acids research. 46(13):6544~6560 (11.561)
2018 SCI Abundance of C-terminal binding protein isoform is a prerequisite for exit from pluripotency in mouse embryonic stem cells: FASEB journal. Online:Published (5.595)
2018 SCI-E FAM188B enhances cell survival via interaction with USP7, Cell Death and Disease: CELL DEATH AND DISEASE. 9:633~633 (5.638)
2017 SCI The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization: International Journal of Biological Macromolecules. 103:965~971 (3.671)
2016 SCI Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity.: Experimental and Molecular Medicine. 48(12):e277~e277 (5.164)
2016 SCI Aldehyde dehydrogenase is used by cancer cells for energy metabolism: Experimental & Molecular Medicine. 48(11):e272~e272 (5.164)
2016 SCI Psat1-Dependent Fluctuations in a-Ketoglutarate Affect the Timing of ESC Differentiation: Cell Metabolism. 24(3):494~501 (17.303)
2016 SCI-E Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion: Oncotarget. 7(31):49397~49410 (5.008)
2016 SCI Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells: eLIFE. 5:1~21 (8.303)
2015 기타 Recombinant Human Laforin Expressed in Insect Cells: Expression, Purification, and Biochemical Characterizations: Journal of the Korean Chemical Society. 59:466~470 (0)
2015 SCI Core Pluripotency Factors Directly Regulate Metabolism in Embryonic Stem Cell to Maintain Pluripotency: Stem Cells. 33:2699~2711 (6.523)
2015 SCI Ctbp2 Modulates NuRD-Mediated Deacetylation of H3K27 and Facilitates PRC2-Mediated H3K27me3 in Active ESC Genes During Exit From Pluripotency: Stem cells. 33(8):2442~2455 (6.523)
2015 SCI AKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage: Nucleic acids research. 43(9):4505~4516 (9.112)
2015 SCI Pontin Functions as an Essential Coactivator for Oct4-Dependent LincRNA expression in Mouse Embryonic Stem Cells: Nature communications [electronic resource]. 6:6810~6810 (11.47)
2015 SCI-E Metabolism in embryonic and cancer stemness: Archives of pharmacal research. 38(3):381~388 (2.046)
2015 SCI ATP-citrate lyase regulates cellular senescence via an AMPK-and p53-dependent pathway.: The FEBS Journal. 282(2):361~371 (4.001)
2014 SCI Modulation of lysine methylation in myocyte enhancer factor 2 during skeletal muscle cell differentiation: Nucleic Acids Research. 42(1):224~234 (8.808)
2013 SCI Menin mediates epigenetic regulation via histone H3 lysine 9 methylation.: Cell Death & Disease. 4:e583~e583 (6.044)
2013 SCI Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress: Nucleic Acids Res. 41(4):2180~2190 (8.278)
2012 SCI O-GlcNAc regulates pluripotency and reprogramming by directly acting on core components of the pluripotency network: Cell Stem Cell. 11:62~74 (25.421)
2011 SCI Histone chaperones cooperate to mediate Mef2-targeted transcriptional regulation during skeletal myogenesis.: Biochem Biophys Res Commun.. 407:541~547 (2.484)
2010 SCI Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors.: Biochem Biophys Res Commun.. 401:327~332 (2.484)
2009 SCI Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin: Exp Mol Med.. 41:471~477 (2.481)
2009 SCI Cabin1 restrains p53 activity on chromatin: Nat Struct Mol Biol.. :910~915 (12.712)
2009 SCI Ferritin binds and activates p53 under oxidative stress: Biochem Biophys Res Commun. 389:399~404 (2.484)
2007 SCI A new calcineurin inhibition domain in Cabin1: Biochem Biophys Res Commun.. 359:129~135 (2.855)
2007 SCI Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1: J Biol Chem.. 282:11172~11179 (5.808)
2007 SCI Hydrogen peroxide triggers the proteolytic cleavage and the inactivation of calcineurin: J Neurochem.. 100:1703~1712 (4.26)
