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Eun Kyung LEE

Eun Kyung LEE, M.D., Ph.D. (adjunct professor)
Faculty Appointment
(title, department)
Associate Professor, Department of Cancer Biomedical Science, NCC-GCSP
Area of Expertise
Work Experience
2003-2004 Internship, Seoul National University Hospital, Seoul, Korea
2004-2008 Residency, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
2008-2010 Fellowship, Division of Endocrinology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
2010-present Clinical Endocrinologist, Center for Thyroid Cancer, National Cancer Center, Goyang, Korea
Educational Background
2003 Seoul National University College of Medicine (M.D.)
2008 Seoul National University Graduate School of Medicine (M.S.)
2014 Seoul National University Graduate School of Medicine (Ph.D.)
Research Interests (Please place in paragraph form)
Dr. Eun Kyung LEE MD is a clinical specialist of Center for Thyroid Cancer and associate scientist of Research Institute at National Cancer Center, Korea. As obtained MD and PhD degree from Seoul National University School of Medicine and completed fellowship in Division of Endocrinology and Metabolism at Seoul National University Hospital, she actively involved in thyroid cancer research focusing on thyroid cancer and thyroid hormone metabolism.

Dr. Lee has participated several phase II and III clinical trials, including SELECT trial of lenvatinib, a second tyrosine kinase inhibitor approved for differentiated thyroid cancer. Her research interests include the genetic risk factors and biomarkers of thyroid cancer and the development of clinical therapeutic protocol for advanced thyroid cancer.
International Collaboration
2006- Member, Korean Endocrine Society
2007- Member, Korean Thyroid Association
2009- Member, Endocrine Society
2013- Member, Korean Diabetes Association
2013- Member, European Association for the Study of Diabetes
2021 SCI-E A Multicenter, randomized, controlled trial for Assessing the usefulness of Suppressing Thyroid stimulating hormone target levels after thyroid lobEctomy in low to intermediate Risk thyroid cancer patients (MASTER): A Study Protocol: ENDOCRINOLOGY AND METABOLISM. :~ (3.257)

2021 SCI-E Best Achievements in Clinical Thyroidology in 2020: ENDOCRINOLOGY AND METABOLISM. :~ (3.257)

2021 SCI-E Factors Affecting Central Node Metastasis and Metastatic Lymph Node Ratio in Papillary Thyroid Cancer: OTOLARYNGOLOGY-HEAD AND NECK SURGERY. Online:Published (2.341)

2020 SCI-E Association among BMI, gnetic variants of FTO, and thyroid cancer risk: a hospital-based case-control study of the cancer screenee cohort in Korea: CANCER RESEARCH AND TREATMENT. Online:Published (3.761)

2020 SCI-E Effect of initial treatment choice on 2-year quality of life in patients with low-risk papillary thyroid microcarcinoma: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. Online:Published (5.399)

2020 SCI-E Randomized phase II study of platinum-based chemotherapy plus controlled diet with or without metformin in patients with advanced non-small cell lung cancer: LUNG CANCER. 151:8~15 (4.702)

2020 SCI-E A Phase II Multi-Center, Non-Randomized, Parallel Group, Non-Inferiority Study to Compare the Efficacy of No Radioactive Iodine Remnant Ablation to Remnant Ablation Treatment in Low- to Intermediate-Risk of Papillary Thyroid Cancer: The MOREthyroid Trial Protocol: ENDOCRINOLOGY AND METABOLISM. 35(3):571~577 (3.257)

2020 SCI-E Long work hours are associated with hypothyroidism: a cross-sectional study with population-representative data: THYROID. Online:Published (5.227)

2020 SCI-E Aspirin use is not associated with lower thyroid cancer risk: A nationwide nested case-control study: THYROID. 30(6):829~837 (5.227)

2019 SCI Lesion-based Evaluation Predicts Treatment Response to Lenvatinib For Radioactive Iodine-Refractory Differentiated Thyroid Cancer: A Korean Multicenter Retrospective Study: Thyroid. Online:Published (7.786)

2019 SCI-E The binary presence or absence of lymph node metastasis or extrathyroidal extension is not associated with survival in papillary thyroid cancers: Implications for staging systems: CANCER EPIDEMIOLOGY. Online:Published (2.619)

2019 SCI Tumor doubling time predicts response to sorafenib in radioactive iodine-refractory differentiated thyroid cancer: Endocrine journal. 66(7):597~604 (1.94)

2019 SCI Longitudinal Assessment of Quality of Life According to Treatment Options in Low-Risk Papillary Thyroid Microcarcinoma Patients: Active Surveillance or Immediate Surgery (Interim Analysis of MAeSTro): Thyroid. Online:Published (7.786)

2019 SCI Integrative analysis of genomic and transcriptomic characteristics associated with progression of aggressive thyroid cancer: NATURE COMMUNICATIONS. 10(1):2764~2764 (11.878)

2019 SCI-E Natural Killer Cells and Thyroid Diseases: ENDOCRINOLOGY AND METABOLISM. 34(2):132~137 (0)

2018 SCI Genome-wide Association Study Reveals Distinct Genetic Susceptibility of Thyroid Nodules from Thyroid Cancer: The Journal of Clinical Endocrinology and Metabolism. 103(12):4384~4394 (5.789)

2018 기타 A Case Report of Severe Hypocalcemia and Hypothyroidism after Tyrosine Kinase Inhibitor Treatment: INTERNATIONAL JOURNAL OF THYROIDOLOGY. 11(2):88~91 (0)

2018 SCI Total thyroidectomy's association with survival in papillary thyroid cancers and the high proportion of total thyroidectomy in low-risk patients: Analysis of Korean nationwide data: Surgery. Online:Published (3.574)

2018 SCI Genetic variations in TAS2R3 and TAS2R4 bitterness receptors modify papillary carcinoma risk and thyroid function in Korean females: SCIENTIFIC REPORTS. 8(1):15004~15004 (4.122)

2018 SCI-E Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro): Endocrinology and metabolism. Online:Published (0)

2018 SCI-E Incidence of Diabetes After Cancer Development : A Korean National Cohort Study: JAMA oncology. 4(8):1099~1105 (20.871)

2018 SCI-E Favorable glycemic response after pancreatoduodenectomy in both patients with pancreatic cancer and patients with non-pancreatic cancer: Medicine. 97(18):e0590~e0590 (2.028)

2018 SCI Interaction between alcohol consumption and methylenetetrahydrofolate reductase polymorphisms in thyroid cancer risk: National Cancer Center cohort in Korea: Scientific reports. 8(1):4077~4077 (4.122)

2017 SCI-E Development and Evaluation of a Korean Version of a Thyroid Specific Quality-of-Life Questionnaire Scale in Thyroid Cancer Patient: Cancer Research And Treatment. 50(2):405~415 (3.772)

2017 기타 Secular Trends for Diagnostic Motives and Environmental Risk Factors in Thyroid Cancer Using Questionnaire Survey: Int J Thyroidology. Online:Published (0)

2017 SCI Defining Radioiodine-Refractory Differentiated Thyroid Cancer: Efficacy and Safety of Lenvatinib by Radioiodine-Refractory Criteria in the SELECT Trial: Thyroid. 27(9):1135~1141 (5.515)

2017 SCI Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer: Nature Communications. 8:15966~15966 (12.124)

2017 기타 Acute Hyperglycemia Associated with Anti-Cancer Medication: Endocrinology and Metabolism. 32:23~29 ()

2016 SCI Long-term Recurrence of Small Papillary Thyroid Cancer and Its Risk Factors in a Korean Multicenter Study: The Journal of Clinical Endocrinology & Metabolism. 102(2):625~633 (5.531)

2016 기타 2016 Revised Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Thyroid Cancer: International Journal of Thyroidology. 9:59~126 ()

2016 SCI-E nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer: Oncotarget. 7(46):75000~75012 (5.008)

2016 SCI-E Metabolic syndrome in breast cancer survivors with high carbohydrate consumption: The first report in community setting: Clinical Nutrition. Online:Published (4.487)

2015 기타 Rare Concurrence of Triple Primary Thyroid Cancer: A Patient of Papillary Carcinoma, Follicular Carcinoma, and Primary Lymphoma of the Thyroid: International Journal of Thyroidology. 8:216~220 ()

2015 SCI Administration of Radioactive Iodine Therapy Within 1 Year After Total Thyroidectomy Does Not Affect Vocal Function.: Journal of nuclear medicine : official publication, Society of Nuclear Medicine.. 56(10):1480~1486 (6.16)

2015 SCI Identification of occult tumors by whole-specimen mapping in solitary papillary thyroid carcinoma.: Endocrine-Related Cancer. 22(4):679~686 (4.805)

2015 SCI Postoperative simultaneous integrated boost-intensity modulated radiation therapy for patients with locoregionally advanced papillary thyroid carcinoma: preliminary results of a phase II trial and propensity score analysis.: The Journal of clinical endocrinology and metabolism. 100(3):1009~1017 (6.209)

2015 SCI-E Improvement of diabetes and hypertension after gastrectomy: A nationwide cohort study: World journal of gastroenterology. 21(4):1173~1181 (2.369)

2014 SCI-E Biomarkers of thyroid function and autoimmunity for predicting high-risk groups of thyroid cancer: a nested case-control study: BMC Cancer. 14(1):873~873 (3.319)

2014 SCI Therapeutic potential of Dickkopf-1 in wild-type BRAF papillary thyroid cancer via regulation of β-catenin/E-cadherin signaling: The Journal of clinical endocrinology and metabolism. 99(9):E1641~E1649 (6.31)

2014 기타 Recurrent hypoglycemia triggered by sorafenib therapy in a patient with hemangiopericytoma: Endocrinology and metabolism. 29(2):202~205 (0)

2014 SCI Risk factors for recurrence after therapeutic lateral neck dissection for primary papillary thyroid cancer.: Ann Surg Oncol. 21(6):1884~1890 (3.943)

2014 SCI Long-term metformin use reduces gastric cancer risk in type 2 diabetics without insulin treatment: a nationwide cohort study.: Alimentary Pharmacology and Therapeutics. 39(8):854~863 (5.478)

2013 SCI DNA Methylation of MAPK Signal-inhibiting Genes in Papillary Thyroid Carcinoma: AntiCancer Research. 33(11):4833~4839 (1.713)

2013 SCI Differential Protein Expression of Lymph Node Metastases of Papillary Thyroid Carcinoma Harboring the BRAF Mutation: Anticancer research. 33(10):4357~4364 (1.713)

2013 SCI Extent of thyroidectomy affects vocal and throat functions: A prospective observational study of lobectomy versus total thyroidectomy: Surgery. 154:611~620 (3.373)

2013 SCI Changes in the clinicopathological characteristics and outcomes of thyroid cancer in Korea over the past 4 decades: Thyroid. 23(7):797~804 (3.544)

2012 SCI Serum thyroglobulin level measured after thyroxine withdrawal is useful to predict further recurrence in whole body scan-negative papillary thyroid cancer patients after reoperation: Endocrine journal. 59(11):1021~1030 (2.027)

2012 SCI Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice: Toxicology and Applied Pharmacology. 263(2):131~137 (4.447)

2012 SCI Preoperative serum thyroglobulin as a useful predictive marker to differentiate follicular thyroid cancer from benign nodules in indeterminate nodules.: Journal of Korean medical science.. 27(9):1014~1018 (0.993)

2011 SCI The association of the BRAF(V600E) mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer: A Meta-Analysis.: Cancer. 118(7):1764~1773 (4.771)

2011 기타 Clinical Characteristics of Langerhans Cell Histiocytosis with Hypothalamo-Pituitary Involvement: Endocrinology and metabolism. 26:38~43 ()

2010 SCI Tumor Size and Age Predict the Risk of Malignancy in Hurthle Cell Neoplasm of the Thyroid and Can Therefore Guide the Extent of Initial Thyroid Surgery: Thyroid. 20:1229~1234 (2.602)

2010 SCI-E The effect of external beam radiotherapy volume on locoregional control in patients with locoregionally advanced or recurrent nonanaplastic thyroid cancer: Radiation Oncology. 5:69~69 (0)

2009 기타 The clinical characteristics of hypothyroidism after sunitinib treatment in a Korean population: Korean Journal of Internal Medicine. 76:37~43 ()

2008 기타 Metabolic Regulation of Nuclear Receptors: Endocrinology and metabolism. 23:155~164 ()

2008 SCI Derivation of a new equation for estimating creatinine clearance by using fat-free mass and serum creatinine concentration in Korean patients with type 2 diabetes mellitus.: Diabetes Research and Clinical Practice. 83(1):44~49 (1.888)

2008 SCI Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans.: Clinical Endocrinology. 70(1):66~74 (3.398)

2007 기타 Mediastinal uptake misinterpreted as metastasis in papillary thyroid cancer: Endocrinology and metabolism. 22:460~464 ()

2006 기타 A Case of Aortic Dissection Associated with Cushing's Syndrome: Endocrinology and metabolism. 21:556~559 ()

2006 기타 A Case of Adrenocortical Carcinoma showing Variable Cortisol Production during the Clinical Course: Endocrinology and metabolism. 21:419~423 ()