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In Hoo KIM

In Hoo KIM, M.D., Ph.D.(full-time professor)
Faculty Appointment
(title, department)
Professor, Department of Cancer Biomedical Science, NCC-GCSP
Area of Expertise
Molecular Oncology/Anti-Cancer Bio-therapeutics
Work Experience
Professor and Chairman, Department of Biochemistry, Dong-A University College of Medicine, Korea(1986 -1998)
Assistant Professor, Department of Cell Biology, Baylor College of Medicine(1998 -2001)
Principal Scientist,Research Institute, National Cancer Center(2001-2013)
Director, Research Institute, National Cancer Center (2005-2006/2011-2013)
Dean, National Cancer Center Graduate School of Cancer Science and Policy (2013-2017)
Educational Background
Ph.D., Biochemistry , Seoul National University(1989)
M.D., Medicine, Seoul National University(1984)
Research Interests
Dr. In Hoo KIM, Professor of NCC-GCSP, earned his MD from Seoul National University College of Medicine,PhD from Department of Biochemistry, Seoul National University, Korea, and completed postdoctoral fellow training in Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, at National Institutes of Health, Bethesda, Maryland, USA.
His current research interests include development of RNA-based therapeutics, gene/immune therapy, molecular imaging, biomarkers, druggable targets and cancer nano medicine.
International Collaboration
Member, American Association for Cancer Research (AACR)
Member, Scientific Council, International Agency for Research on Cancer (IARC)
2021 SCI-E ELAC2, an Enzyme for tRNA Maturation, Plays a Role in the Cleavage 0f a Mature tRNA to Produce a tRNA-Derived RNA Fragment During Respiratory Syncytial Virus Infection: FRONTIERS IN MOLECULAR BIOSCIENCES. 7:609732~ (4.188)

2020 SCI-E Therapeutic Application of Drug-Conjugated HER2 Oligobody (HER2-DOligobody): INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 21(9):E3286~ (4.556)

2020 SCI-E A regulatory noncoding RNA, nc886, suppresses esophageal cancer by inhibiting the AKT pathway and cell cycle progression: CELLS. 9(4):801~ (4.366)

2019 SCI Mechanism mediated by a noncoding RNA, nc886, in the cytotoxicity of a DNA-reactive compound: Proc. Natl. Acad. Sci. U. S. A.. 116(17):8289~8294 (9.58)

2018 SCI Phase I trial of intravenous Ad5CRT in patients with liver metastasis of gastrointestinal cancers: Cancer gene therapy. 26(5-6):174~175 (4.044)

2018 SCI-E Increased prevalence of metabolic syndrome in adult cancer survivors: Asian first report in community setting: Cancer epidemiology. 58:130~136 (2.888)

2018 SCI-E Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling: CELL DEATH AND DISEASE. 9(11):1083~1083 (5.638)

2017 SCI Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation.: Experimental & Molecular Medicine. 49(7):e351~e351 (5.063)

2017 SCI Preclinical development of a humanized neutralizing antibody targeting HGF: Experimental & Molecular Medicine. 49(3):e309~e309 (5.063)

2017 SCI-E Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III: Epigenomics. 9(2):171~187 (4.541)

2016 SCI-E nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer: Oncotarget. 7(46):75000~75012 (5.008)

2016 SCI-E Oncogenic function and clinical implications of SLC3A2-NRG1 fusion in invasive mucinous adenocarcinoma of the lung: Oncotarget. 7(43):69450~69465 (5.008)

2016 SCI Histone variant H3F3A promotes lung cancer cell migration through intronic regulation: Nature Communications. 7:12914~12914 (11.329)

2016 SCI An aptamer-antibody complex (oligobody) as a novel delivery platform for targeted cancer therapies: Journal of Controlled Release. 229:1~9 (7.441)

2016 SCI-E Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma: Theranostics. 6:357~368 (8.854)

2015 SCI Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2.: Nature communications [electronic resource]. Online:Published (11.47)

2015 SCI Distinctive responses of brain tumor cells to TLR2 ligands:: Glia. 63(5):894~905 (6.031)

2015 SCI Pontin Functions as an Essential Coactivator for Oct4-Dependent LincRNA expression in Mouse Embryonic Stem Cells: Nature communications [electronic resource]. 6:6810~6810 (11.47)

2015 SCI The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.: Nature communications [electronic resource]. 6:6340~6340 (11.47)

2014 SCI-E Development of Replication-competent Adenovirus for Bladder Cancer by Controlling Adenovirus E1a and E4 Gene Expression with the Survivin Promoter: Oncotarget [electronic resource]. 5(14):5615~5623 (6.627)

2014 SCI-E Preclinical Efficacy Testing for Stomach and Liver Cancers using a Hollow Fiber Assay: Cancer Research and Treatment. 46(2):186~193 (2.975)

2014 SCI Low-mass-ion discriminant equation: A new concept for colorectal cancer screening.: International Journal of Cancer. 134(8):1844~1853 (5.007)

2014 SCI Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model: Cancer Letters. 344(2):223~231 (5.016)

2014 SCI TopBP1 deficiency impairs V(D)J recombination during lymphocyte development: The EMBO journal. 33(3):217~228 (10.748)

2014 SCI Bispecific Her2Χ cotinine antibody in combination with cotinine-(histidine) 2-iodine for the pre-targeting of Her2-positive breast cancer xenografts.: Journal of cancer research and clinical oncology. 140(2):227~233 (3.009)

2014 SCI Intravesical instillation of c-MYC inhibitor KSI-3716 suppresses orthotopic bladder tumor growth: The Journal of Urology. 191(2):510~518 (3.753)

2014 SCI Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8: Biomaterials. 35(1):578~589 (8.312)

2014 SCI-E ROS-responsive activatable photosensitizing agent for imaging and photodynamic therapy of activated macrophages: Theranostics. 4(1):1~11 (7.827)

2013 SCI-E Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway: Oncotarget. 4(10):1791~1803 (6.636)

2013 SCI Adenovirus expressing both thymidine kinase and soluble PD1 enhances anti-tumor immunity by strengthening CD8 T cell response: Molecular Therapy. 21(3):688~695 (7.041)

2013 SCI p53 acetylation enhances Taxol-induced apoptosis in human cancer cells: Apoptosis. 18(1):110~120 (3.949)

2012 SCI Over-expression of miR-145 Enhances the Effectiveness of HSVtk gene Therapy for Malignant Glioma: Cancer Letters. 320(1):72~80 (4.238)

2012 SCI Overexpression of IFITM1 Has Clinicopathologic Effects on Gastric Cancer and Is Regulated by an Epigenetic Mechanism: AMERICAN JOURNAL OF PATHOLOGY. 181(1):43~52 (4.89)

2012 SCI Positive conversion of negative signaling of CTLA4 potentiates antitumor efficacy of adoptive T-cell therapy in murine tumor models: Blood. 119(24):5678~5687 (9.898)

2012 SCI Lipid MALDI profile classifies non-small cell lung cancers according to the histologic type: Lung cancer. 76(2):197~203 (3.434)

2012 기타 Gold nanorods for target selective SPECT/CT imaging and photothermal therapy in vivo: Quantitative Imaging in Medicine and Surgery. 2(1):1~11 (0)

2012 SCI FX: an RNA-Seq analysis tool on the cloud: Bioinformatics. 28(5):721~723 (5.468)

2011 SCI An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells.: Cancer letters.. 313(1):76~83 (4.864)

2011 SCI-E Alterations in Cell Proliferation Related Gene Expressions in Gastric Cancer: Critical reviews in Eukaryotic Gene Expression. 21(3):237~254 (4.11)

2011 SCI Dual Functionality of Myeloperoxidase in rotenone-exposed brain-resident immune cells: American Journal of Pathology. 179(2):964~979 (5.224)

2011 SCI A highly sensitive magnetite nanoparticle as a simple and rapid stem cell labelling agent for MRI tracking: Journal of Materials Chemistry. 21:7742~7747 (5.101)

2011 SCI Gold nanorod-photosensitizer complex for near-infrared fluorescence imaging and photodynamic/photothermal therapy in vivo: ACS Nano. 5(2):1086~1094 (9.865)

2011 SCI eIF3m expression influences the regulation of tumorigenesis-related genes in human colon cancer.: Oncogene. 30(4):398~409 (7.414)

2010 SCI The development of the conditionally replication-competent adenovirus: replacement of E4 orf1-4 region by exogenous gene.: Journal of Gene Medicine. 12(5):453~462 (2.968)

2009 SCI Recruitment of Sprouty1 to immune synapse regulates T cell receptor signaling: Journal of Immunology. 183:7178~7186 (6)

2009 SCI-E Sphingosine 1-phosphate induces vesicular endothelial growth factor expression in endothelial cells: BMB reports. 10:685~690 (1.811)

2009 SCI Comparison of two full automatic synthesis methods of 9- (4-[18F]Fluoro-3-hydroxymethylbutyl)guanine using different chemistry modules: Applied Radiation & Isotopes. 67:1758~1763 (1.114)

2009 SCI-E IN-1130, a novel transforming growth factor-beta type I receptor kinase (activin receptor-like kinase 5) inhibitor, promotes regression of fibrotic plaque and corrects penile curvature in a rat model of Peyronie's disease.: J Sex Med. 6(5):1284~96 ()

2009 SCI-E IN-1130, a Novel Transforming Growth Factor-beta Type I Receptor Kinase (Activin Receptor-like Kinase 5) Inhibitor, Promotes Regression of Fibrotic Plaque and Corrects Penile Curvature in a Rat Model of Peyronie's Disease: Journal of Sexual Medicine. 6(5):1284~1296 (5.393)

2009 SCI Validation of tissue-specific promoter-driven tumor-targeting trans-splicing ribozyme system as a multifunctional cancer gene therapy device in vivo: Cancer Gene Therapy. 16:113~125 (3.005)

2008 SCI Differentiation between human normal colon mucosa and colon cancer tissue using ToF-SIMS imaging technique and principal component analysis: Applied Surface Science. 255:1119~1122 (1.406)

2008 SCI Sulfatide, a major lipid component of myelin sheath, activates inflammatory responses as an endogenous stimulator in brain-resident immune cells: Journal of Immunology. 181:8077~8087 (6.068)

2008 SCI Regulation of TLR2 expression by prostaglandins in brain glia.: Journal of Immunology. 180(12):8400~8409 (6.068)

2008 SCI-E Efficient Gene Expression System Using the RTP801 Promoter in the Corpus Cavernosum of High-Cholesterol Diet-Induced Erectile Dysfunction Rats for Gene Therapy.: The Journal of Sexual Medicine. 5:1355~1364 (6.199)

2008 SCI o-GlcNAc transferase is activated by CaMKIV-dependent phosphorylation under potassium chloride-induced depolarization in NG-108-15 cells: Cellular signalling. 20:94~104 (4.147)

2008 SCI Antitumor effects of systemically delivered adenovirus harboring trans-splicing ribozyme in intrahepatic colon cancer mouse model: Clinical Cancer Research. 14:281~290 (6.25)

2007 SCI In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cells: Molecular Therapy. 16:74~80 (5.862)

2007 SCI Molecular imaging of endogenous mRNA expression in a mouse tumor model by adenovirus harboring trans-splicing ribozyme: FEBS Letters. 28:5396~5400 (3.263)

2006 SCI Reversal of drug resistance in breast cancer cells by transglutaminase 2 inhibition and nuclear factor-B inactivation: Cancer Research. 66:10936~10943 (7.616)

2006 SCI Transglutaminase 2 mediates polymer formation of I-kBa through C-terminal glutamine cluster: Journal of Biological Chemistry. 281:34965~34972 (5.854)

2006 SCI Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1: Nature Immunology. 7:1057~1065 (27.011)

2006 SCI-E Changes in gene expression with increased transglutaminase 2 in a SH-SY5Y cell line: Frontiers in Bioscience. 11:2774~2781 (2.623)

2005 SCI Apoptosis of mink lung epithelial cells by co-treatment of low-dose staurosporine and transforming growth factor-beta1 depends on the enhanced TGF-beta signaling and requires the decreased phosphorylation of PKB/Akt: Biochem Biophys Res Commun. 328:1170~1181 (2.904)

2004 SCI DNA mociroarray analysis of the correlation between gene expression patterns and acquired resistance to 5-FU/cisplatin in gastric cancer: Biochemical and Biophysical Research Communications. 316:781~789 (2.904)

2004 SCI Liposome-complexed adenoviral gene transfer in cancer cells expressing various levels of coxsackievirus and adenovirus receptor: J Cancer Res Clin Oncol. 130:167~177 (2.162)

2002 SCI Changes in expression of cell cycle regulators after G1 progression upon repetitive thioacetamide treatment in rat liver: Exp Mol Med. 34(5):361~366 (1.267)

2001 SCI Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector: Proc Natl Acad Sci USA. 98:13282~13287 (10.7)