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Ho Kyung SEO, M.D., Ph.D.

Name
Ho Kyung SEO, M.D., Ph.D.
Faculty Appointment
(title, department)
Professor, Department of Cancer Biomedical Science,
NCC-GCSP Head,
Center for Urologic Cancer Chief,
Department of Urology Senior scientist,
Division of tumor Immunology
Area of Expertise
Urologic Cancer (Bladder Cancer)
E-mail
seohk@ncc.re.kr
Work Experience
Assistant Professor, Department of Urology, Ewha Woman’s University College of Medicine
Visiting scholar, Memorial Sloan-Kettering Cancer Center, USA
Chief, Biomarker Branch, Research Institute, National Cancer Center Head, Center for Urologic Cancer, Hospital, National Cancer Center
Chief, Department of Urology, Hospital, National Cancer Center
Senior scientist, Division of tumor Immunology, Research Institute, National Cancer Center
Educational Background
1994 MD, Busan National University College of Medicine
1997 MS, Busan National University Graduate School of Medicine
2006 PhD, Busan National University Graduate School of Medicine
Research Interests
Development of new cancer therapeutic modality,
Orthotopic bladder cancer model and PDX,
Clinical trials for bladder cancer patients (including immune check-point inhibitor, FGFR inhibitor, Antibody-drug conjugation)
International Collaboration
Achievements
2020 SCI-E Optimizing frontline therapy in advanced urothelial cancer Translational Andrology and Urology 2.113

2020 SCI-E Novel G9a/DNMT first-in-class dual reversible inhibitor has potent antitumor effect in bladder cancer Translational Cancer Research 1319~1321 1.07

2020 SCI-E Usefulness of the mass screening program for colorectal cancer in China: further long-term validation is needed to confirm its value Annals of Translational Medicine 3.6890

2020 SCI-E Docetaxel-resistant prostate cancer cells become sensitive to gemcitabine due to the upregulation of ABCB1 The Prostate 453~462 2.8760

2020 SCI-E Survival prognoses of Heng intermediate-risk patients with metastaticrenal cell carcinoma treated with immunotherapy or targeted therapy: A real-world, single-center retrospective study Investigative and clinical urology 146~157 1.638

2020 SCI-E Identification of Significant Prognostic Tissue Markers Associated with Survival in Upper Urinary Tract Urothelial Carcinoma Patients Treated with Radical Nephroureterectomy: A Retrospective Immunohistochemical Analysis Using Tissue Microarray cancer research and treatment Published 3.3630

2020 SCI-E Survival of patients receiving systematic therapy for metachronous or synchronous metastatic renal cell carcinoma: a retrospective analysis BMC cancer 688~688 2.9330

2020 SCI-E Significant clinicopathologic prognostic factors for bladder recurrence, progression, and cancerspecific survival after surgery among patients with upper urinary tract urothelial carcinoma investigative and clinical urology 432~442 1.6380

2020 SCI-E Developing a Prediction Model for Disease-free Survival from Upper Urinary Tract Urothelial Carcinoma in the Korean Population cancer medicine Published 3.3570

2020 SCI-E Use of docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in Korean patients: A retrospective study invesitgative and clinical urology 195~201 1.6380

2020 SCI-E Correlation analyses of computed tomography and magnetic resonance imaging for calculation of prostate volume in colorectal cancer patients with voiding problems who cannot have transrectal ultrasonography BIOMED RESEARCH INTERNATIONAL 7029450~7029450 2.1970

2020 SCI-E Single-Center Analysis of Human Papillomavirus Infection and P16INK4A Expression among Korean Patients with Penile Cancer BIOMED RESEARCH INTERNATIONAL 6940582~6940582 2.1970

2020 SCI-E Liver metastasis and Heng risk are prognostic factors in patients with non-nephrectomized synchronous metastatic renal cell carcinoma treated with systemic therapy PLOS ONE e0211105~e0211105 2.7760

2018 SCI-E Immune checkpoint inhibitors for urothelial carcinoma Investigative and clinical urology 285~296 0

2018 SCI-E Oncologic, Perioperative Outcomes of Female Radical Cystectomy: Results from a Multicenter Study in Korea. CANCER RESEARCH AND TREATMENT Published 3.23

2018 기타 "Prostatectomy Provides Better Symptom-Free Survival Than Radiotherapy Among Patients With High-Risk or Locally Advanced Prostate Cancer After Neoadjuvant Hormonal Therapy " Korean Journal of Urological Oncology 126~134 0

2018 기타 Clear cell papillary renal cell carcinoma: A case report and review of the literature World Journal of Nephrology 155~160 0

2018 SCI-E Effect of Neoadjuvant Hormone Therapy on Resection Margin and Survival Prognoses in Locally Advanced Prostate Cancer after Prostatectomy Using Propensity-Score Matching Biomed Research International 7~7 2.583

2018 기타 The Effect of the First Computed Tomography Examination on Renal Function During the Initial Cancer Work-up in Newly Diagnosed Cancer Patients without Chronic/Kidney Disease: A Retrospective, Single-institution, Observational Study journal of cancer science and therapy 332~337 0

2018 SCI-E Laparoscopy Versus Open Nephroureterectomy in Prognostic Outcome of Patients with Advanced Upper Tract Urothelial Cancer: A Retrospective, Multicenter, Propensity-Score Matching Analysis CANCER RESEARCH AND TREATMENT Published 3.23

2018 SCI-E Retrospective Study of the Significant Predictive Role of Inflammatory Degree in Initial and Repeat Prostate Biopsy Specimens for Detecting Prostate Cancer CANCER RESEARCH AND TREATMENT Published 3.23

2018 기타 A Surgically Treated Case of Ureterovesical Amyloidosis of the Bladder in a Patient with Idiopathic Thrombocytopenia Case Reports in Urology 1059349~1059349 0

2018 기타 Prostate stem cell antigen mRNA in blood is a predictor of survival after radical prostatectomy in patients with high-risk prostate cancer. Oncotarget 26291~26298 0

2018 SCI-E The neutrophil-to-lymphocyte ratio makes the Heng risk model improve better the prediction of overall survival in metastatic renal cell cancer patients Japanese Journal of clinical Oncology 835~840 2.37

2018 SCI-E Risk of second primary Cancer among bladder Cancer patients: a population-based cohort study in Korea. BMC Cancer 617~617 3.288

2018 SCI-E "The Comparison of Oncologic Outcomes between Open and Laparoscopic Radical Nephroureterectomy for the Treatment of Upper Tract Urothelial Carcinoma: A Korean Multicenter Collaborative Study " CANCER RESEARCH AND TREATMENT 240~251 3.23

2018 SCI Prognostic significance of nephrectomy in metastatic renal cell carcinoma treated with systemic cytokine or targeted therapy: A 16-year retrospective analysis Scientific reports 2974~2974 4.122

2018 SCI-E "Retrospective analysis of 25 immunohistochemical tissue markers for differentiating multilocular cystic renal neoplasm of low malignant potential and multicystic renal cell carcinoma " Histology and histopathology 589~596 2.025

2017 SCI-E "Hand-Holding during Cystoscopy Decreases Patient Anxiety, Pain, and Dissatisfaction: A Pilot Randomized Controlled Trial. " Urologia internationalis 222~227 1.611

2017 SCI-E Lifestyle Risk Prediction Model for Prostate Cancer in a Korean Population Cancer Research and Treatment 1194~1202 3.772

2017 기타 "The retrospective analysis of prognostic significance of smoking status in bladder cancer " Korean Journal of Urological Oncology 1~10 0

2017 기타 Renal myxofibrosarcoma in a woman: A cese report and literature review Journal of Cytology and Histology 4~8 0

2017 SCI Electrostatic interaction of tumor-targeting adenoviruses with aminoclay acquires enhanced infectivity to tumor cells inside the bladder and has better cytotoxic activity Drug Delivery 49~58 6.402

2017 SCI-E Establishment and Application of Prostate Cancer CirculatingTumor Cells in the Era of Precision Medicine BioMed Research International 1~9 2.476

2017 SCI-E Retrograde pyelography predicts retrograde ureteral stenting failure and reduces unnecessary stenting trials in patients with advanced non-urological malignant ureteral obstruction PLOS one e0184965~e0184965 2.806

2017 SCI-E Survival outcomes of double- and triple-sequential targeted therapy in patients with metastatic renal cell carcinoma: a retrospective comparison Oncotarget Published 5.168

2017 SCI-E Establishment and application of bladder cancer patient-derived xenografts as a novel preclinical platform Translational Cancer Research s733~s743 1.167

2017 SCI-E "A retrospective comparative study of progression-free survival and overall survival between metachronous and synchronous metastatic renal cell carcinoma in intermediate or poor risk patients treated with VEGF-targeted therapy " Oncotarget 93633~93643 5.168

2017 SCI-E "Recommended oral sodium bicarbonate administration for urine alkalinization did not affect the concentration of mitomycin-C in non-muscle invasive bladder cancer patients " oncotarget Published 5.168

2017 SCI-E "The prognostic value of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue markers in localized renal cell carcinoma: A retrospective study of tissue microarrays using immunohistochemistry " PLOS ONE Published 2.806

2017 SCI-E The effect of predisposing atheroembolic risk factors on renal functional recovery between laparoscopy and open technique in patients with T1-stage renal cell carcinoma who underwent partial nephrectomy: A retrospective comparison study Japanese Journal of Clinical Oncology 876~882 1.905

2017 SCI-E Initial computed tomography imaging details during first-line systemic therapy is of significant prognostic value in patients with naive, unresectable metastatic renal cell carcinoma PLOS ONE e0177975~e0177975 2.806 2017 SCI-E Second Primary Cancer Risk Among Kidney Cancer Patients in Korea: A Population-Based Cohort Study Cancer Research and Treatment 293~301 3.772

2017 SCI-E Effect of renal embolization in patients with synchronous metastatic renal cell carcinoma: A retrospective comparison of cytoreductive nephrectomy and systemic medical therapy Oncotarget 49615~49624 5.168

2016 SCI Prostate Cancer in a Patient With a Family History of BRCA Mutation: a Case Report And Literature Review Journal of Korean Medical science 377~381 1.2560

2016 SCI-E Baseline Chronic Kidney Disease and Ischemic Method of Partial Nephrectomy Are Important Factors for the Short- and Long-Term Deterioration in Renal Function for Renal Cell Carcinoma Staged T1-T2: A Retrospective Single Center Study BioMed Research International 5398381~5398389 2.1340

2016 SCI-E Current Trends in the Incidence and Survival Rate of Urological Cancers in Korea Cancer Research and Treatment Published 4.2450

2016 SCI-E Bladder chondrosarcoma plus urothelial carcinoma in recurred transitional cell carcinoma of the upper urinary tract: a case report and literature review "World Journal of Surgical Oncology " 270~270 1.2860

2016 SCI-E Pretreatment prognostic nutritional index is an independent predictor of survival in patients with metastatic renal cell carcinoma treated with targeted therapy Clinical Genitourinary Cancer 100~111 2.5990

2016 SCI-E "The establishment of a growth-controllable orthotopic bladder cancer model through the down-regulation of c-myc expression" Oncotarget Published 5.0080

2016 SCI-E "A retrospective study of predictive factors for unexpectedly prolonged or shortened progression-free survival and overall survival among patients with metastatic renal cell carcinoma who received first-line targeted therapy " BMC cancer 577~577 3.2650

2016 SCI-E Evaluation of the efficacy of solifenacin for preventing catheter-related bladder discomfort after transurethral resection of bladder tumors in patients with non-muscle invasive bladder cancer: a prospective, randomized, multicenter study . clinical Genitourinary cancer 157~162 2.5990

2016 SCI-E "PSCA, Cox-2, and Ki-67 are independent, predictive markers of biochemical recurrence in clinically localized prostate cancer: A retrospective study " Asian Journal of Andrology Published 2.6440

2016 SCI-E "Prostate Stem Cell Antigen Expression in Radical Prostatectomy Specimens Predicts Early Biochemical Recurrence in Patients with High Risk Prostate Cancer Receiving Neoadjuvant Hormonal Therapy " PloS one e0151646~e0151646 3.0570

2016 SCI-E "Systemic treatments for metastatic renal cell carcinoma: 10-year experience of immunotherapy and targeted therapy " cancer research and treatment 1092~1101 4.2450

2016 SCI-E Outcomes of pelvic exenteration for recurrent or primary locally advanced colorectal cancer Annals of Surgical Treatment and Research Issue3~

2016 SCI-E Risk of Second Primary Cancer among Prostate Cancer Patients in Korea: A Population-Based Cohort Study PLOS ONE e0140693~e0140693 3.2340

2016 SCI-E The quantified level of circulating prostate stem cell antigen mRNA relative to GAPDH level is a clinically significant indictor for predicting biochemical recurrence in prostate cancer patients after radical prostatectomy BioMed Research International 292454~292454 1.5790

2016 SCI-E Outcomes of pelvic exenteration for recurrent or primary locally advanced colorectal cancer Annals of Surgical Treatment and Research 131~137 0

2016 SCI-E "The prevalence and outcomes of pT0 disease after neoadjuvant hormonal therapy and radical prostatectomy in high-risk prostate cancer. " BMC urology 82~82 1.4130

2016 기타 "Oncologic aspects of long-term followed incidental prostate cancer detected by cystoprostatectomy in Korean patients. " Prostate international 56~61 0

2016 SCI "Overexpression of BRCA1 or BRCA2 in prostatectomy specimens is predictive of biochemical recurrence after radical prostatectomy " Histopathology 673~679 3.4530

2016 SCI Trends in the Use of Chemotherapy Before and After Radical Cystectomy in Patients with Muscle-invasive Bladder Cancer in Korea Journal of Korean medical science 1150~1156 1.2660

2016 SCI-E "Changes in urination according to the sound of running water using a mobile phone application " "PloS one [electronic resource] " 0126798~0126798 3.2340

2016 SCI-E Overexpression of ERG and wild-type PTEN are associated with favorable clinical prognosis and low biochemical recurrence in prostate cancer "PloS one [electronic resource] " 0122498~0122498 3.2340

2016 SCI P70S6K and Elf4E Dual Inhibition Is Essential to Control Bladder Tumor Growth and Progression in Orthotopic Mouse Non-muscle Invasive Bladder Tumor Model Journal of Korean medical science 308~316 1.2660

2016 SCI-E A case report of partial nephrectomy of mucinous cystadenocarcinoma in kidney and its literature review Cancer research and treatment 838~842 3.3180