Faculty Directory
- Name
- Kang, Joon Hee
- Faculty Appointment
(title, department)
-
Department of cancer biomedical science Senior researcher, New Cancer Cure Bio(co.)
- Area of Expertise
- Cancer
- Contact no
- +82-31-920-2227
- E-mail
- wnsl2820@ncc.re.kr
- Work Experience
-
Senior researcher, research institute, MDbiolab.
Researcher, research institute, national cancer cener, korea
- Educational Background
-
2006-2012 Dongguk university, seoul, korea ; bachrlor’s degree
2012-2014 Dongguk university, seoul, korea ; master’s degree
2016-2020 Dongguk university, seoul, korea ;Ph.D
- Research Interests
-
My goal is to develop a drug to treat cancer patients. Currently, New Cancer cure Bio Co., Ltd. is conducting research on the development of new anticancer drugs that target cancer metabolism. In addition to cancer metabolism, research on cancer control by transglutaminase 2 is also ongoing.
- Achievements
-
1. Lee JS, Choi J, Lee SH, Kang JH, Ha JS, Kim HY, Jang H, Yook JI, Kim SY. Oxoglutarate Carrier Inhibition Reduced Melanoma Growth and Invasion by Reducing ATP Production. Pharmaceutics. 2020 Nov 23;12(11):1128.(2020)
2. Lee JS, Lee H, Jang H, Woo SM, Park JB, Lee SH, Kang JH, Kim HY, Song J, Kim SY. Targeting Oxidative Phosphorylation Reverses Drug Resistance in Cancer Cells by Blocking Autophagy Recycling. Cells. 2020 Sep 1;9(9):2013. (2020)
3. Lee JS, Oh SJ, Choi HJ, Kang JH, Lee SH, Ha JS, Woo SM, Jang H, Lee H, Kim SY. ATP Production Relies on Fatty Acid Oxidation Rather than Glycolysis in Pancreatic Ductal Adenocarcinoma. Cancers (Basel). 2020 Sep 1;12(9):2477. (2020)
4. Lee SH, Kang JH, Ha JS, Lee JS, Oh SJ, Choi HJ, Song J, Kim SY. Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1α-p300 Binding in Renal Cell Carcinoma. Int J Mol Sci. 2020 Jul 17;21(14):5042. (2020)
5. Kang JH, Lee SH, Lee JS, Oh SJ, Ha JS, Choi HJ, Kim SY. Inhibition of Transglutaminase 2 but Not of MDM2 Has a Significant Therapeutic Effect on Renal Cell Carcinoma. Cells. 2020 Jun 16;9(6):1475.(2020)
6. J-S Lee, H Lee, S Lee, J H Kang, S-H Lee, S-G Kim, E S Cho, N H Kim, J I Yook, S-Y Kim. Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation. EBioMedicine. Feb;40:184-197. (2019)
7. Lee SH, Jeon Y, Kang JH, Jang H, Lee H, Kim SY. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer. Cancers (Basel). 2020 May 28;12(6):1382.(2019)
8. Lee JS, Kim SH, Lee S, Kang JH, Lee SH, Cheong JH, Kim SY. Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation. Sci Rep. 2019 Nov 8;9(1):16313. (2019)
9. S-H Lee, W-K Lee, N Kim, J H Kang, K-H Kim, S-G Kim, J-S Lee, S Lee, J Lee, J Joo, W S Kwon, S Y Rha and S-Y Kim. Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition. Cancers (Basel). Nov 19;10(11) (2018)
10. S Lee, J-S Lee, J Seo, S-H Lee, J H Kang, J Song & S-Y Kim. Targeting Mitochondrial Oxidative Phosphorylation Abrogated Irinotecan Resistance in NSCLC. Sci Rep. Oct 24;8(1) (2018)
11. J H kang, S-H Lee, H-S Cheong, C-H Lee, S-Y Kim. Transglutaminase 2 Promotes Autophagy by LC3 Induction through p53 Depletion in Cancer Cell. Biomol Ther (Seoul). Jan 1;27(1):34-40. (2019)
12. N Kim, J H Kang, W-K Lee, S-G Kim, J-S Lee, S-H Lee, J B Park, K-H Kim, Y-D Gong, K Y Hwang, S-Y Kim. Allosteric inhibition site of transglutaminase 2 is unveiled in the N terminus. Amino Acids. Nov;50(11):1583-1594. (2018)
13. J Park, J-K Shim, J H Kang, J Choi, J H Chang, S-Y Kim, S-G Kang. Regulation of bioenergetics through dual inhibition of aldehyde dehydrogenase and mitochondrial complex I suppresses glioblastoma tumorspheres. Neuro Oncol. Jun 18;20(7):954-96. (2018)
14. J H Kang, H J Kim, M K Park and C H Lee. Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2. Biomolecules & Therapeutics; 25(6): 625-633 (2017)
15. J H Kang, S-H Lee, D Hong, J-S Lee, H-S Ahn, J-H Ahn, T W Seong, C-H Lee, H Jang, K M Hong, C Lee, J-H Lee and S-Y Kim. Aldehyde dehydrogenase is used by cancer cells for energy metabolism. Experimental & Molecular Medicine 48, e272; (2016)
16. J H Kang, S-H Lee, J-S Lee, B Nam, T W Seong, J Son, H Jang, K M Hong, C Lee, S-Y Kim. Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion. Oncotarget, Vol. 7, No. 31. (2016)
17. J-S Lee, J H Kang, S-H Lee, D Hong, J Son, K M Hong, J Song and S-Y Kim. Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC. Cell Death and Disease, e2511; (2016)
18. J-S Lee, J H Kang, S-H Lee, C-H Lee, J Son, S-Y Kim. Glutaminase 1 inhibition reduces thymidine synthesis in NSCLC. Biochemical and Biophysical Research Communications 477 374-382. (2016)
19. J H Kang, S-H Lee and S-Y Kim. Discovery of a novel target for renal cell carcinoma: transglutaminase 2. Cell Death and Disease (2016) 7, e2200. (2016)
20. J H Kang, J-S Lee, D Hong, S-H Lee, N Kim, W-K Lee, T-W Sung, Y-D Gong and S-Y Kim. Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy. Cell Death and Disease, e2163. (2016)
21. H J Byun, K J Kang, M K Park, H J Lee, J H Kang, E-J Lee, Y R Kim, H J Kim, Y W Kim, K C Jung, S-Y Kim, C H Lee. Ethacrynic Acid Inhibits Sphingosylphosphorylcholine- Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition. Biomol Ther. Sep 30;21(5):338-42. (2013)
22. M K Park, S H Jo, H J Lee, J H Kang, Y R Kim, H J Kim, E-J Lee, Y J Koh, K O Ahn, K C Jung, S H Oh, S-Y Kim, C H Lee. Novel suppressive effects of cardamonin on the activity and expression of transglutaminase-2 lead to blocking the migration and invasion of cancer cells. Life Sci Feb 7;92(2):154-60. (2013)
23. H J Lee, M K Park, E-J Lee, Y L Kim, H J Kim, J H Kang, H M Kim, A Y Lee, C H Lee. Histamine receptor 2-mediated growth-differentiation factor-15 expression is involved in histamine-induced melanogenesis. Int J Biochem Cell Biol.Dec;44(12):2124-8(2012)
24. M K Park, S-A Cho, H J Lee, E-J Lee, J H Kang, Y L Kim, H J Kim, S H Oh, C-S Choi, H Lee, S-Y Kim and C H Lee. Suppression of Transglutaminase-2 is Involved in Anti- Inflammatory Actions of Glucosamine in 12-O-Tetradecanoylphorbol-13-Acetate -Induced Skin Inflammation Biomol Ther 20(4), 380-385 (2012)
25. J H Kang, M K Park, H J Kim, Y L Kim and C H Lee, Isolation of Soil Microorganisms Having Antibacterial Activity and Antimigratory Effects on Sphingosylphosphorylcholine-induced Migration of PANC-1 Cells. Toxicol Res Vol. 27, No. 4, pp. 241-246. (2011)
